NIH GUIDE, Volume 21, Number 17, May 8, 1992


P.T. 34




  Drug Design 

National Institute of Child Health and Human Development

The Contraceptive Development Branch of the Center for Population

Research, National Institute of Child Health and Human Development

(NICHD), is interested in stimulating further investigations into the

design, synthesis, and testing of peptide antagonists of LHRH as

gonadotropin inhibitors. Such investigations will also involve the

biological evaluation of the peptides, preferably by the contractor.

The Contraceptive Development Branch is prepared, however, to evaluate

such peptides if the contractor is unable to do so.  The goal is to

obtain LHRH antagonists that are more potent than those currently

available, and are devoid of histamine releasing properties.  Proposals

merely to collect peptides from various sources And/or only perform

biological assays are excluded from consideration at this time.

Organizations must have adequate facilities to conduct the proposed

peptide program.  All responsible sources may submit an offer that

shall be considered by the agency.  It is anticipated that four cost-

reimbursement, incrementally funded type contracts will be awarded

under the Request for Proposals (RFP) for a period of two years,

beginning December 1, 1992.  The Government estimates the effort for

each contract to be approximately 3.5 staff years annually.

This announcement is not an RFP.  RFP-NICHD-CD-92-17 will be issued on

or about May 13, 1992. Proposals will be due approximately 60 days

thereafter.  Copies of the RFP may be obtained by sending a written

request to the address listed below.  Please enclose a self-addressed

label. Requests may also be made by FAX: (301) 402-0915.

Paul J. Duska, Contracting Officer

Contracts Management Branch

Office of Grants and Contracts

National Institute of Child Health and Human Development

Executive Plaza North, Room 610

9000 Rockville Pike

Bethesda, MD  20892


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