NIH GUIDE, Volume 21, Number 14, April 10, 1992




P.T. 34






National Cancer Institute


PLEASE NOTE:  This announcement has been published in the Commerce

Business Daily.  Because of the late date of this announcement in the

Guide, it is published for information purposes only.


The National Cancer Institute (NCI) is seeking contractors to perform

the above named project.  The contracts will create a field

station(s) for epidemiologic studies in states that produce grain and

livestock and/or in states with a significant proportion of minority

farmers that produce other nonperishable commodities.  It is

anticipated that at least two field stations will be necessary to

create a large cohort (approximately 156,000 persons) that can be

followed prospectively for 10 years or more to obtain detailed

information on agricultural exposures, diet, cooking practices, and

other factors of etiologic interest for the study of cancer and other

diseases.  The field station(s) shall be located in a state(s) with

population-based cancer registries and pesticide applicator

registries with at least 20,000 registrants.  It is desirable, but

not mandatory, for the state to also have a birth defects registry.

The study is designed to investigate biomarkers of exposure and

disease.  The entire cohort will include farm owner/operators

(70,000), their spouses (56,000), or commercial and noncommercial

applicators (30,000).  The cohort will be assembled by enrolling

applicators as they come to obtain or renew a pesticide application

license at the Agricultural Extension Service Offices.  The spouses

of farm applicators will be invited to enroll in the cohort when

their spouse is enrolled.  It is anticipated that it will take three

to four years to assemble the entire cohort since licenses are

renewed on a three-four year cycle in many states.


The NCI expects to award three cost-reimbursement, completion type

contracts for a 60-month period.  The Request for Proposals (RFP) was

available on March 23, 1992 and proposals are due by April 27, 1992.

Awards are anticipated by September 30, 1992.  All responsible

sources meeting the criteria are encouraged to submit an offer and

will be considered by the NCI.  No collect calls will be accepted.

Copies of the RFP may be obtained by submitting a written request to:


Barbara A. Shadrick, Contract Specialist

Research Contracts Branch, OD

Cancer Etiology Contracts Section

National Cancer Institute

Executive Plaza South, Suite 620

Bethesda, MD  20892

Telephone:  (301) 496-8611



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