ADDENDUM INNOVATIVE TECHNOLOGIES FOR THE MOLECULAR ANALYSIS OF CANCER RELEASE DATE: December 20, 2002 NOTICE: NOT-CA-03-007 National Cancer Institute (NCI) (http://www.nci.nih.gov) This addendum is to inform potential applicants of a change in the Research Objectives under Program Announcements PAR-01-104 and PAR-01- 105. The change is as follows: This notice is to draw the attention of applicants responding to PAR- 01-104 and PAR-01-105. In addition to the research objectives found in the current PARs, NCI would also like to solicit applications for developing high throughput assays for methylation and histone acetylation, key components in epigenetic regulation of cellular transformation. Epigenetics is the study of mechanisms that involve mitotically heritable changes in DNA other than changes in nucleotide sequence Epigenetic changes are needed for normal growth but these changes are misdirected in cancer. A critical step towards a better understanding of the epigenetic alterations during carcinogenesis is to develop new approaches and to improve existing techniques for genome- wide methylation analysis and histone deacetylation of chromatin. In particular, improved and novel technologies must allow the use of epigenetic changes as early detection biomarkers. Current technologies are set up for detecting epigenetic changes by analytical tools. In order to screen a large population, comprehensive, quantitative, high- throughput strategies are needed. All other provisions of PAR-01-104 and PAR-01-105 remain unchanged. The complete PARs can be accessed at the following URLs: http://grants.nih.gov/grants/guide/pa-files/PAR-01-104.html http://grants.nih.gov/grants/guide/pa-files/PAR-01-105.html INQUIRIES Inquiries regarding this notice may be directed to: Mukesh Verma, Ph.D. Cancer Biomarkers Research Group, Division of Cancer Prevention National Cancer Institute EPN, Room 3147 MSC 7362 Bethesda, MD 20892-7362 Telephone: 301-496-3893 Fax: 301-402-8990 Email: vermam@mail.nih.gov

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