Notice of Availability of Administrative Supplements for Collaborative Activities to Promote Metabolomics Research

Notice Number: NOT-RM-11-024

Update: The following update relating to this announcement has been issued:

Key Dates

Release Date:  December 15, 2011
Receipt Date:  March 15, 2012 
Earliest Anticipated Start Date:  July 1, 2012

Issued by

This Funding Opportunity Announcement (FOA) is developed as a Common Fund initiative ( through the NIH Office of the NIH Director, Office of Strategic Coordination (  The FOA will be administered by the National Cancer Institute (NCI/NIH), ( on behalf of the NIH)


This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress

This Funding Opportunity Announcement (FOA) solicits administrative supplement applications to provide funds to current NIH-funded research projects for new collaborations between basic or clinical researchers and metabolomics experts to pursue biomedical studies requiring a metabolomics approach that are within the scope of the peer-reviewed and approved project. 

The purpose of this program is to support collaborative, multi-disciplinary basic and clinical research using metabolomics and help expand the cadre of investigators experienced in metabolomics study design, analytical methodology, and data interpretation. This funding opportunity is part of the Common Fund program “Increasing Metabolomics Research Capacity”.  The overall goal of this Common Fund Program is to increase and improve the nation’s ability to undertake metabolomics analyses in translational and clinical research.


Metabolomics is the study of low molecular weight molecules or metabolites found within cells and biological systems and the metabolome is a measure of the functional output of biological pathways.  Metabolites are conserved across various animal species, facilitating the extrapolation of research findings in laboratory animals to humans and thus clinical and translational research.  Common technologies for measuring the metabolome include mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR), which can measure hundreds to thousands of unique chemical entities (UCE).  Metabolomic profiling in basic, epidemiological, clinical and translational studies has revealed potential new biomarkers of disease and therapeutic outcome and led to novel mechanistic understanding of pathogenesis.  These include the recent biomarkers of diabetes risk (Nat.Med.17:448-453. 2011), novel metabolites associated with cancer (Nature 462:739-44. 2009), and the discovery of over 500 unique lipids in plasma (J. Lipid Res. 51: 3299-3305. 2010).

Comprehensive, high quality metabolomics investigations require access to specialized equipment and highly trained personnel with expertise in bioinformatics, biochemistry, physiology, and spectrometry.  Proper metabolomics study design, particularly for studies involving clinical samples, is critical for translationally relevant outcomes and interpretation of metabolomics results requires an in-depth understanding metabolism and physiology.  Few institutions are equipped to handle the volume of analyses required to undertake comprehensive studies and fewer still have personnel with metabolomics expertise. An investment in training investigators in the disciplines required to undertake metabolomics analyses is expected to help increase the capacity to apply this powerful approach to translational questions. This initiative will support new collaborations that exploit metabolomics approaches to move basic and clinical research towards translational goals and will increase the number of investigators cross-trained in metabolomics methodology, bioinformatics analysis, biochemistry and physiology. 

Budget and Funding Information

The total amount of funds available for these awards is approximately $2 million for FY2012, contingent upon receiving scientifically meritorious proposals. 12-14 awards are anticipated from this solicitation.

A maximum budget of $100,000 direct costs for one year may be requested for this supplement program.


This announcement is for supplements to Research Project Grants (R00/R01/R37/U01/P01).

To be eligible:

IMPORTANT:  The research proposed by the NIH grantee in the supplement application must be within the original scope of the NIH-supported grant project.  The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives as long as they are within the original scope of the project.  Any cost increases need to result from making modifications to the project in order to take advantage of opportunities that would increase the value of the project consistent with its originally approved objectives and purposes.

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, the request must be signed by the Authorized Organizational Representative/Signing Official (AOR/SO), and must describe the need for additional funding and the categorical costs.

Submit one original, hard copy of the request packet (with original signatures of the authorized business official) to the address listed below:

Bryan Baker
Office of Grant Administration
National Cancer Institute
6130Executive Blvd, Suite T44
Rockville MD 20852

In addition, applicants are encouraged to send an electronic copy of the submitted supplement request as an e-mail attachment in PDF format to the email listed above

Requests should be submitted on the PHS398 Application Guide forms (font size and other formatting rules apply as designated in the instructions), as indicated below. Include only the following elements:

Cover Letter which cites this Notice, and the following information:

PHS 398 Form Page 1 (Face page)

PHS 398 Form Page 2

A brief proposal describing the project, including:

Resource Sharing Plan


Administrative supplement requests will be reviewed administratively by NIH Staff. Selection factors will include the following:


Program Inquiries:

Inquiries and discussion of plans for responding to this Notice are strongly encouraged.  Interested applicants can contact the Program Officer for the parent research grant or the Common Fund Working Group representative for this FOA listed below for questions relevant to the scientific scope of the request.

Barbara Spalholz, Ph.D.
National Cancer Institute
Telephone: 301-496-7028

Grants Management Contact:

For administrative inquiries, please contact the NIH grants administrative representative listed below.

Crystal Wolfrey
Office of Grants Administration
National Cancer Institute
Telephone: 301-496-8634

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy
NIH . . . Turning Discovery Into Health

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.