Revised PHS 416-1 (Individual Fellowship Ruth L. Kirschstein National Research Service Award Application) Now Available

Notice Number: NOT-OD-09-004

Key Dates
Release Date: October 14, 2008

Issued by
National Institutes of Health (NIH),
Agency for Healthcare Research and Quality (AHRQ),

EFFECTIVE DATE: The newly revised “Application for an Individual Fellowship Ruth L. Kirschstein National Research Service Award” (PHS 416-1, Rev. 9/08) forms and instructions are now available and will be accepted for submission/receipt dates beginning in December 2008.  All applications received for submission dates in December 2008 and thereafter must use only the new forms and instructions.  NIH and AHRQ anticipate this to be the last paper-based submission for Individual Fellowship applications.  Plans are still on target to transition Individual Fellowship applications to electronic submission beginning with the April 2009 cycle.   For more information on NIH's transition plans, including a timeline for the transition, see the website for Electronic Submission of Grant Applications

The newly revised forms and instructions are available at The previous version of the PHS 416-1 (Rev. 10/05) will remain available on the NIH Forms Page at to accommodate the October 23 submission for PAR-06-536.

Applicants and their sponsors submitting fellowship applications for submission/receipt dates in December 2008 and thereafter are hereby notified that instructions in the existing fellowship FOAs may not always correspond to those in the newly revised PHS 416-1 (Rev. 9/08). Applicants are advised to follow instructions in the newly revised PHS 416-1 (Rev. 9/08).

When preparing competing fellowship applications, fellows and sponsoring institution officials are encouraged to review the FOA instructions carefully for any updated information.

The forms available on the website continue to be provided in two formats—MS Word and PDF-fillable using Adobe Acrobat Reader Software. Free Adobe Software may be accessed at Applicants are strongly encouraged to access the forms and instructions via the Internet because they provide valuable links to current policy documents and allow easy navigation of the instructions. For further information, contact

The new edition of the PHS 416-1 (Rev. 9/08) includes significant changes to the overall structure of the application. Applicants must use only the form pages provided in the new version of the PHS 416-1. Do not mix old and new versions.

As in the past, applicants should read the instructions carefully. The following is a list of notable changes.

Notable Changes to Form PHS 416-1 (Rev. 9/08):

Form Page 1 (Face Page)

Form Page 3

General Changes of Note to the PHS 416-1 Instructions (Rev. 9/08):

This edition of the PHS 416-1 incorporates numerous policy changes and notifications implemented since the 10/05 revision of the PHS 416-1 application.

The PHS 416-1 Instructions includes a Summary of Changes (see Page I-1).  Additional changes are highlighted as follows:

Implementation of Grants.Gov Terminology

As part of the ongoing effort to keep the PHS 416-1, PHS 398 and the SF424 (R&R) synchronized, new terminology is implemented:



Competing continuation application

Renewal application

Revision or amendment [to application]

Resubmission application

Competing supplement

Revision application

Training site

Project/performance site.
For fellowships this is also known as the Training Site.

Duly authorized representative

Authorized Organizational Representative.  For fellowships this is the representative of the Sponsoring Institution.

Structure of Document:

Cover Letter:  A suggested cover letter format is provided for greater consistency and to facilitate the use of requests for specific Institutes or Centers (ICs) or Scientific Review Groups.

Other Content Changes:

-All six human subjects exemptions are provided in one scenario; corresponding instructions modified accordingly.  
-New scenario "Delayed Onset Human Subjects Research" incorporated.

Appendix Format: Incorporates the new NIH policy requiring appendix material to be submitted only on CDs in PDF format, and no longer on paper. See NIH Guide Notice NOT-OD-08-031,

When applicable, instructions have been revised to incorporate appropriate policy changes. However, detailed information pertaining to policies, assurances, definitions and other information continues to be found in Part III: Policies, Assurances, Definitions and Other Information.


Inquiries on any changes to the forms and instructions may be directed to:

Grants Information
Office of Extramural Research
National Institutes of Health
Phone: 301-710-0267
TTY: 301-451-5936

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.