Notice Number: NOT-OD-08-094
Key Dates
Release Date: August 8, 2008
Contract Proposal Receipt Date: November 3, 2008
Issued by
National Institutes of Health (NIH) (www.nih.gov)
Centers for Disease Control and Prevention (CDC) (www.cdc.gov)
Innovative technologies and methodologies fuel progress in biomedical and behavioral research and represent an increasingly important area of the economy. The Small Business Innovation Research (SBIR) program provides support for research and development (R&D) of new or improved technologies and methodologies that have the potential to succeed as commercial products.
The purpose of this notice is to (1) announce the issuance of the Solicitation of the National Institutes of Health and the Centers for Disease Control and Prevention for Small Business Innovation Research Contract Proposals (PHS 2009-1) with a receipt date of November 3, 2008; and (2) inform the public about the opportunities that the SBIR program offers to small business concerns as well as to scientists at research institutions.The SBIR legislation requires the Public Health Service (PHS), Department of Health and Human Services, and certain other Federal agencies to reserve 2.5 percent of their extramural research or R&D budgets for an SBIR program. (The NIH SBIR set-aside requirement for FY 2008 is $579.8 million.)
The offeror organization must be a small business concern as defined by the Small Business Administration and described in the Contract Solicitation. The primary employment of the principal investigator MUST be with the small business concern at the time of award and during the conduct of the proposed project. In accord with the intent of the SBIR program to increase private sector commercialization of innovations derived from Federal R&D, scientists at research institutions can play an important role in an SBIR project by serving as consultants and/or subcontractors to the small business concern. Generally, up to one-third of the Phase I budget may be spent on consultant and/or subcontractual costs, and, generally, up to one-half of the Phase II budget may be spent on such costs. In this manner, a small business concern with limited expertise and/or research facilities may benefit from teaming with a scientist(s) at a research institution; for the scientist(s) at a research institution, this team effort provides support for R&D not otherwise obtained. The SBIR program consists of the following three phases:
PHASE I: The objective of this phase is to determine the scientific and technical merit and feasibility and potential for commercialization of the proposed research or R&D efforts and the quality of performance of the small business concern, before consideration of further Federal support in Phase II. Generally, Phase I SBIR awards do not exceed $100,000 for direct costs, Facilities and Administrative (F&A) costs, and negotiated fixed fee for a period generally not to exceed six months.
PHASE II: The objective of this phase is to continue the research orR&D efforts initiated in Phase I. Funding shall be based on the results of Phase I and the scientific and technical merit and commercial potential of the Phase II proposal. Only Phase I contractors are eligible to apply for Phase II funding, and Phase II proposals may be submitted ONLY upon the request of the Contracting Officer. (However, see "Fast-Track" Initiative below.) Generally, Phase II awards do not exceed $750,000 for direct costs, F&A costs, and negotiated fixed fee for a period generally not to exceed two years. That is, generally, a two-year Phase II project does not cost more than $750,000 for that project. Only one Phase II award may be made for any SBIR project.
PHASE III: The objective of this phase is for the small business concern to pursue, with non-SBIR funds, the commercialization of the results of the research or R&D funded in Phases I and II.
"FAST-TRACK" INITIATIVE: (Applicable only to proposals submitted to the NIH and only if an awarding component indicates that it is accepting Fast-Track proposals for a particular topic.)
The Fast-Track initiative is an opportunity for small business concerns to submit both a Phase I and Phase II proposal for concurrent peer review. This initiative also has the potential to minimize any funding gap between Phase I and Phase II. Proposals must be prepared in accordance with Phase I and Phase II proposal preparation instructions.
Following are the research topics contained in the PHS 2009-1 Solicitation:
National Institutes of Health (NIH)
National Cancer Institute (NCI)
- 229 Development of Molecular Pharmacodynamic Assays for Targeted Therapies
- 249 System to Analyze and Support Biomarker Research and Development Strategies
- 255 Development of Anticancer Agents
- 256 Innovative Methods for Manufacturing Safe, Effective Cancer Therapeutics
- 257 Biopsy Instruments and Devices that Preserve Molecular Profiles in Tumors
- 258 Innovative Strategies to Protect Radiosensitive Organs and Structures During Radiation Therapy
- 259 Quantitative Tissue Imaging For Clinical Diagnosis and Treatment
- 260 High Level Programming Language to Expedite Development of User Interfaces
- 261 Mobile Computing for Consumer-centered Cancer Prevention and Control
- 262 Health Information Technology to Facilitate Patient-centered Communication in Cancer-related Care
- 263 Antibody Array for Cancer Detection and Diagnosis
- 264 Novel and Improved Methods for Detecting Epigenetic Modifications
- 265 Development of shRNA Library Screening Technology for Cancer-Related Targets
- 266 Nanotechnology Imaging and Sensing Platforms for Improved Diagnosis of Cancer
- 267 Multifunctional Therapeutics Based on Nanotechnology
- 268 Novel Antibody Epitope Mapping Technologies
- 269 Development of Novel Protein Expression Technologies for Glycosylated Cancer Related Proteins
- 270 Peptide Aptamers: New Tools to Capture and Study Protein Interactions in Lieu of Immunological Reagents
National Center for Research Resources (NCRR)
- 012 Visualizing Biomedical Research Characteristics
National Heart, Lung, and Blood Institute (NHLBI)
- 035 Ultrasonic Wave Transmitter, Transmission Line and Receiver for Interventional MRI
- 040 Nanoprobes for Non-Invasive Detection of Atherosclerotic Plaques
- 043 Development of Pathogen Inactivation Technologies for Blood Components
- 044 Development of Cell-based Bioassays Using Induced Pluripotent Stem (iPS) Cell Lines
- 045 Development of Novel Formulations for Iron Chelators to Treat Iron Overload in Patients on Transfusion Therapy
- 046 Multiplexed Assay Platforms for Protein Biomarkers of Cardiovascular Disease
- 047 Transcatheter Ablation Devices for Arrhythmia Treatment
- 048 Developing Novel Anticoagulants and Synthetic Heparins
- 049 Development of Gene Transfer Approaches for Correction of Genetic Blood Diseases
- 050 Wireless Communications Systems for Magnetic Resonance Imaging (MRI) Guided Surgery
- 034 Simple, Low-Cost, Onsite Biomarker Test Kits for Alcohol-Associated Disorders
- 035 Biological Sample Repository for Alcohol Research
- 036 Identification of miRNAs as Biomarkers for Alcohol-Induced Disorders
National Institute of Allergy and Infectious Diseases (NIAID)
- 017 Clinical Sample Collection and Processing Technologies for Infectious Disease Diagnostics
National Institute on Drug Abuse (NIDA)
- 099 Innovative Technologies to Support Economic Research in the Drug Abuse Treatment System
- 100 Instrument Development
- 101 Rapid Assessment Tools of Sexual and Drug Use Risk
- 102 Electronic Drug Abuse Treatment Referral Systems for Physicians
- 103 Virtual Reality Simulations to Train Caregivers/Providers
- 104 Improvement of Reliability and Validity of Reporting of Sensitive Data
- 105 Development of Therapeutic Agents for Substance Use Disorders
- 106 Pharmaceutical Approaches for Development of Pharmacotherapies for Drug Addiction
- 107 Design and Synthesis of Treatment Agents for Drug Abuse
- 108 Repository for Substance Abuse Brain Imaging Data (SBIR/STTR)
- 109 Web Based Cognitive/Neuropsychological Testing for Substance Abuse
- 110 Development Of Science Education Materials Or Programs
- 111 Screening, Characterization and Validation Assays for Protein Capture Reagents
- 112 Tool Development for New or Improved Capture Reagents
National Institute of Mental Health (NIMH)
- 061 Home-Based Lithium Level Testing for Bipolar Patients
Centers for Disease Control and Prevention (CDC)
National Center on Birth Defects and Developmental Disabilities (NCBDDD)
- 008 Development of Web site with Modules for Study Participants and Fellow Researchers
- 009 Development of a Publication Database and Information Retrieval System with Announcement Feature
- 010 Development of Standardized Evaluation Software for Blood Disorder Public Health Surveillance Systems
- 011 Animated Software depicting Iron Out of Balance
- 012 Development and Evaluation of Web-based Applications Using Emerging Technologies and New Media
- 013 Application of Gaming Technology to Communicate Health Messages and Promote Healthy Living among Persons with Disabilities
- 014 Use of Cutting-edge Technology to Communicate with and Educate Health Care Professionals about Birth Defects, Developmental Disabilities, and Ways to Improve the Health and Wellness of Persons with Disabilities
National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP)
- 028 Inexpensive, portable, user-friendly calibration of aneroid and electronic blood pressure devices
- 029 Dynamic Health Promotion Decision Making for Preconception Health and Healthcare
- 030 Development and Evaluation of a Quality and Affordable Electric-Assist Bicycle for Commuting
Immunization Safety Office (ISO)
- 006 Novel or Enhanced Technology for Vaccination Delivery and Immunization Programs
National Center for Immunization and Respiratory Diseases (NCIRD)
- 001 Novel Methods for Detecting Viruses in Clinical Samples
Inquiries
Eligibility requirements, definitions, submission procedures, review considerations, contract proposal forms and instructions, and other pertinent information, including the "Fast-Track" Initiative, are contained in the Solicitation (PHS 2009-1). The Solicitation, including contract proposal forms, is available electronically through the NIH "Small Business Research Funding Opportunities” Web site. See SBIR Phase I Contract Solicitation PHS 2009-1 (PDF [http://grants.nih.gov/grants/funding/SBIRContract/PHS2009-1.pdf] or MS Word [http://grants.nih.gov/grants/funding/SBIRContract/PHS2009-1.doc]). Be sure to use the appropriate CONTRACT PROPOSAL forms as they differ from the SF424 (R&R) GRANT application forms.Note: The SBIR Phase I Contract Solicitation is available ONLY via electronic means. Potential offerors are encouraged to check the NIH Small Business Research Funding Opportunities Web site for updates on the program. Any updates or corrections to the Solicitation will be posted there.
Contracting Officers
Any small business concern that intends to submit an SBIR contract proposal under this Solicitation should provide the appropriate contracting officer(s) with early, written notice of its intent, giving its name, address, e-mail, telephone, and topic number(s). If a topic is modified or canceled before the Solicitation closes, only those companies that have expressed such intent will be notified.National Institutes of Health (NIH)
National Cancer Institute (NCI)Ms. Mary Landi-O’Leary
Phone: (301) 435-3807
Fax: (301) 480-0309
Email: [email protected]
Mr. John Taylor
Phone: (301) 435-0327
Fax: (301) 480-3338
E-mail: [email protected]
Mr. John Taylor
Phone: (301) 435-0327
Fax: (301) 480-3338
E-mail: [email protected]
Mr. Matthew Packard
Phone: (301) 443-3041
Fax: (301) 443-3891
Email: [email protected]
Ms. Barbara Shadrick
Phone: (301) 496-7288
Fax: (301) 402-0972
Email: [email protected]
National Institute on Drug Abuse (NIDA)
Mr. Craig Sager
Phone: (301) 443-6677
Fax: (301) 443-7595
Email: [email protected]
National Institute of Mental Health (NIMH)
Ms. Suzanne Stinson
Phone: (301) 443-2696
Fax: (301) 443-0501
Email: [email protected]
Centers for Disease Control and Prevention
For general administrative SBIR program questions, contact:
Dr. Denise Burton
Office of Public Health Research (OPHR)
Office of the Chief Science Officer
Phone: (404) 639-4641
Email: [email protected]
Mr. Jerald O’Hara
Office of Public Health Research (OPHR)
Office of the Chief Science Officer
Phone: (404) 639-4796
Email: [email protected]
National Center on Birth Defects and Developmental Disabilities (NCBDDD)
National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP)
Mrs. Theresa Routh-Murphy
Contracting Officer, NCBDDD/CDC
Phone: (770) 488-2713
Fax: (770) 488-2778
Email: [email protected]
Immunization Safety Office (ISO)
Mr. Alan Sims
Phone: (770) 488-2896
Fax: (770) 488-2670
Email: [email protected]
National Center for Immunization and Respiratory Diseases (NCIRD)
Mr. Paul Rota
Phone: (404) 639-4181
Fax: (404) 639-4187
Email: [email protected]
To understand better the differences between grants and contracts, see Contracts vs. Grants: What's the difference?
and Human Services (HHS)
