ADMINISTRATIVE REVIEW CONSIDERATIONS ADMINISTRATIVE SUPPLEMENTS FOR QUANTITATIVE PHYSICAL MEASUREMENTS AT THE NANOSCALE RELEASE DATE: June 30, 2003 NOTICE: NOT-OD-03-051 National Institutes of Health (NIH) Emerging tools and concepts are providing the ability to generate quantitative data central to a deeper understanding of determining molecular mechanisms underlying normal cellular processes or the changes that attend disease. Ultimately, this understanding will lead to knowledge of the design principles of biology. The trans-NIH Bioengineering Consortium (BECON) announces the availability of administrative supplements for projects that are already studying, at a molecular level, biological or disease processes, or diagnostic or treatment modalities, and that wish to add capabilities to enable analyses of biological nanostructures, assemblies and nanomachines using quantitative physical parameters, such as force, stoichiometry, kinetics, energy utilization and transduction, etc. It is envisioned that these supplements will initiate a process for the creation of blueprints for the design of new nanosystems and tools for health monitoring and maintenance, and disease detection and treatment. The supplements might be used, for example, to: i. establish new collaborations; o cover the costs for extended visits at another laboratory that has the capacity to develop tools to carry out nanoscale measurements on the biomedical system outlined in the parent grant; or o invite scientists with specific expertise to visit the laboratory of the NIH-funded investigator with the goal of forming partnerships to enhance the aims of the original proposal. ii. add a new experimental paradigm or quantitative measurement complementary to those already described in the grant; or iii. develop a new measurement tool. Requests should explain how the activities proposed under supplemental assistance will provide a unique opportunity to enhance the research project. Supplements are one-time awards and will not extend to subsequent budget periods. The Office of the Director (OD) will commit $1.2 million in FY2003 to fund applications for supplements submitted in response to this Notice. ELIGIBILITY Projects must have a least 12 months of funding remaining after the supplement application receipt date. (A no-cost extension beyond the original Project Period End Date does not confer eligibility). HOW TO APPLY Applicants should submit an original and five copies of a complete application, signed by an authorized business official at their institution, to: Jeffery A. Schloss, Ph.D. National Human Genome Research Institute National Institutes of Health Bldg 31, Room B2-B07 31 Center Drive Bethesda, MD 20892-2033 tel: 301-496-7531 fax: 301-480-2770 e-mail: jeff_schloss@nih.gov The following items should be included in the application: 1. A completed face page (PHS 398), citing the number and title of this Notice on line 2. Documentation of approval from the Institutional Animal Care and Use Committee (IACUC) for any proposed animal studies must be provided. 2. A description of the project (3 page limit), including: o Abstract. o Rationale and description of the work proposed in the supplement. o Specific Aims of the original grant. o Description of the relationship of the supplemental project to the Specific Aims of the parent grant. Requests should explain how the activities proposed under supplemental assistance will provide a unique opportunity to enhance the research project. 3. A budget with justifications for requested direct costs, and stating the F&A cost (see Budget Information, below). ADMINISTRATIVE REVIEW CONSIDERATIONS Applications will be reviewed by NIH staff, and it is expected that for successful applications a resulting Supplemental Notice of Grant Award will be issued within two months of the receipt deadline. All funding decisions are final and are not subject to appeal. Review criteria will include the relevance of the proposed activity to the goals of the project as already funded and to the development of enhanced ability to make quantitative physical measurements on biological nanostructures, assemblies and nanomachines. BUDGET INFORMATION Supplements will be one-time (one year) awards. The maximum amount that the applicant may request depends upon the policies of the Institute that supports the parent grant; applicants must consult the appropriate program official before submitting the supplement request. Awards pursuant to this Notice are contingent upon the availability of funds and the receipt of applications of high scientific merit. RECEIPT DATE: August 1, 2003 AWARD DATE: September 30, 2003 INQUIRIES Inquiries are strongly encouraged, especially regarding budgetary issues. Direct inquiries regarding programmatic or financial matters to the appropriate individual(s) from the Institute that supports the grant for which the supplement will be requested. Contact information for those individuals is available at: http://www.becon.nih.gov/nano_supps.htm.
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