March 3, 2026
National Institute of Neurological Disorders and Stroke (NINDS)
The purpose of this notice is to inform potential applicants of a change in the key dates for notice of funding opportunity (NOFO) PAR-25-049, NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required). Specifically, an additional receipt date of June 6, 2026 has been added to this NOFO for new applications, and an additional receipt date of July 08, 2026 has been added to this NOFO for renewal applications. Accordingly, this NOFO now expires on July 9, 2026.
The following section of PAR-25-049 has been modified.
Part 1. Overview Information
Key Dates
Currently reads:
Application Due Dates | Review and Award Cycles | ||||
|---|---|---|---|---|---|
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
| February 07, 2025 | March 07, 2025 | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 06, 2025 | July 08, 2025 | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 07, 2025 | November 07, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 06, 2026 | March 06, 2026 | Not Applicable | July 2026 | October 2026 | December 2026 |
All applications are due by 5:00 PM local time of applicant organization.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Expiration Date: March 07, 2026
Modified to Read (key changes are adding additional line in table of receipt dates and updating expiration date in bold italics)
Application Due Dates | Review and Award Cycles | ||||
|---|---|---|---|---|---|
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
| February 07, 2025 | March 07, 2025 | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 06, 2025 | July 08, 2025 | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 07, 2025 | November 07, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 06, 2026 | March 06, 2026 | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 06, 2026 | July 08, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
All applications are due by 5:00 PM local time of applicant organization.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Expiration Date: July 09, 2026
Please direct all inquiries to:
Office of Emergency Care Research
National Institute of Neurological Disorders & Stroke (NINDS)
Email: [email protected]