Notice of Availability of Administrative Supplements for the U.S.-JAPAN Brain Research Cooperative Program – U.S. Component

Notice Number: NOT-NS-10-014

Key Dates
Release Date: May 14, 2010
Receipt Date: September 15, 2010, 2011, 2012
Earliest Anticipated Start Date: February 1, 2011

Issued by
National Institute of Neurological Disorders and Stroke (NINDS) (
National Cancer Institute (NCI) (
National Eye Institute (NEI) (
National Institute on Aging (NIA) (
National Institute of Biomedical Imaging and Bioengineering (NIBIB) (
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) (
National Institute on Drug Abuse (NIDA) (
National Institute on Deafness and Other Communication Disorders (NIDCD) (
National Institute of Dental and Craniofacial Research (NIDCR) (
National Institute of Environmental Health Sciences (NIEHS), (
National Institute of Mental Health (NIMH) (


The National Institutes of Health (NIH) announces the continuation of the United States (U.S.) component of the U.S.-Japan Brain Research Cooperative Program (BRCP).  This administrative supplement program will provide funds to research projects supported by the participating NIH Institutes.
The purpose of the BRCP is to promote scientist exchange, training, and research collaborations between neuroscientists from the U.S. and Japan.  The U.S. component of the BRCP supports the following activities: 1) Visit of U.S. scientists to conduct collaborative research and/or to acquire advanced research skills in Japanese institutions, 2) Joint workshops to exchange scientific information and to foster collaborations.


An agreement on “Cooperation in Research and Development in Science and Technology” was signed by the President of the United States and the Prime Minister of Japan on May 1, 1980 and has subsequently been renewed and extended.  Under the umbrella of this Agreement, the NINDS and the National Institute for Physiological Sciences, Okazaki National Research Institutes, Japan, signed a Memorandum of Understanding for a Brain Research Cooperative Program on November 29, 2000.  Since its inception in 2002, the U.S. component of the BRCP has successfully supported U.S. neuroscientists’ collaborative activities at Japanese institutions and international workshops in the neurosciences.  The Japanese component of the BRCP has been active since 2001.  Details of the Japanese component of the program are available at
Within the funding guidelines of the BRCP program, each country supports its own scientists who participate in the aforementioned activities. 

Areas of research interests of the participating NIH Institutes


The current announcement is for supplements to Research Project (R01, R37, R21), Program Project (P01), Center (P50), and Cooperative Agreement (U01, U54) grants funded by the participating NIH Institutes.
IMPORTANT:  The research proposed by the NIH grantee in the supplement application must be within the original scope of the NIH-supported grant project.  The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives as long as they are within the original scope of the project.  Any cost increases need to result from making modifications to the project in order to take advantage of opportunities that would increase the value of the project consistent with its originally approved objectives and purposes.

Activities Supported

Travel Fund

Workshop Fund

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, submit a request to the NINDS (see “How to Apply” section below), not to the Division of Receipt and Referral, Center for Scientific Review. The request must be signed by the authorized Business Official and describe the need for additional funding and the categorical costs.
Requests under this notice should use the PHS 398 forms (rev. 6/2009; available at and include the following elements in the request packet. Font size restrictions apply as designated within the PHS398 (rev. 6/2009) instructions.

1) Cover Letter - Citing this Notice (NOT-NS-10-014), and the following information:

The cover letter must be signed by the authorized organizational representative/institutional official.

2) PHS 398 Form Page 1 (Face page) MS Word  PDF

3) PHS 398 Form Page 2 MS Word  PDF

Note: The project “summary” is that of the administrative supplement, not the parent grant. The Japanese collaborator(s) should be noted under Performance Sites, along with their institution(s).

4) A brief proposal describing the project, including:

a)  A 1-page introduction.

b) Scope of the overall project and the anticipated contribution of the requested supplement (not to exceed five pages). Provide a brief description of the scope of the overall project on which the supplemental request is based.

This section should include a description of the supplement's specific aims, including research design,  methods and data analysis.  Describe the relationship of the supplement request to the parent grant. 

c) Budget for the supplement with a justification that details the items requested, including Facilities and Administrative costs, personnel costs, supplies, travel and other expenses.  Applicants must submit a budget using the same budget format as was used for the parent award.  Any no-cost extension must be in place before submission of the revision application. 

d) Biographical Sketch for all new key personnel (those who are additions on the supplemental project) MS Word  PDF . Letters of commitment from all participants should be included in section L (Consultants) of the Research Plan.

e) Resources page(s) for all key personnel

f) Current grant support (citing the participating NIH Institute)

g) Human Subjects/ Vertebrate Animal documentation (if applicable). Include a current Human Subjects/IRB or Vertebrate Animals/IACUC approval letter, if available. Otherwise, this will be required at the time of funding. All appropriate IRB and IACUC approvals must be in place prior to a supplement award being made. 

Any differences in the involvement or use of human subjects or specimens, or use of vertebrate animals, between the administrative supplement activity and the parent grant should be noted.  When appropriate, details should be provided on the protection of human subjects and inclusion of women, children, and minorities.  Additional guidance on Human Subjects Research and Vertebrate Animals is provided under Part II of the PHS 398 instructions (  

h) Bibliography and References Cited (Section 5 of the PHS 398 Research Plan) should be included.

i) PHS 398 Checklist Form MS Word  PDF

Research Collaborations

In addition to the items outlined in the “Submitting an Administrative Supplement Request” section above, applications for research collaboration/training must also include a Research/Training Plan for the project (not to exceed five pages).  Font size restrictions apply as designated within the PHS398 (rev. 6/2009) instructions.

Research Plans must include:

Joint Workshops 

Joint workshop applications should be developed collaboratively by both the U.S. and Japanese organizers.  In addition to the items outlined in the “Submitting an Administrative Supplement Request” section above, U.S. applications for Joint Workshops must also include a workshop plan.  Font size restrictions apply as designated within the PHS398 (rev. 6/2009) instructions.

Workshop Plans must include:


Within one month of the completion of all collaborative research/training efforts and workshops, U.S. supported investigators are required to submit a final report to the NIH, detailing the following information:

Selection Factors

Administrative supplement requests will be reviewed administratively by the joint U.S.-Japan BRCP Review Committee and Grants Management Staff. Awards will be determined on the selection factors listed below and the availability of funds. All funding decisions are final and not subject to appeal.  Selection factors will include the following:

How to Apply

Applicants are strongly encouraged to contact the respective Program Official listed in this Notice prior to the submission of an administrative supplement application. 

This is a reoccurring announcement.  Applications must be received on or before September 15th of each participating year.  Do not send applications to the NIH Center for Scientific Review. 

Submit one original, hard copy of the request packet (with original signatures of the authorized business official) to the address listed below.  Applications may also be submitted electronically as an e-mail attachment in PDF format with clearly visible signatures from the PD/PI and Authorized Organizational Representative (AOR).

Stacey D. Chambers, M.S.
Office of International Activities
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2179
6001 Executive Boulevard
Rockville, MD 20852-9523  
Phone: 301-496-0690
FAX: 301-480-1080


Inquiries and discussion of plans for responding to this Notice are strongly encouraged. When contacting Program Staff, applicants should be prepared to discuss the purpose, significance and necessity of their visit to Japan and how the collaborative arrangement will benefit their NIH-supported research.  The names and contact information of the Program Staff representing the participating NIH Institutes are listed below:

Yuan Liu, Ph.D.
Chief, Office of International Activities
National Institute of Neurological Disorders and Stroke
6001 Executive Blvd. NSC Room 2187
Bethesda, MD 20892-9523 (USPS)
Rockville, MD 20852 (Courier)
Phone: 301-496-0012
FAX: 301-480-2060

William C. Timmer, Ph.D.
Program Director
Cancer Therapy Evaluation Program
Division of Cancer Therapy and Diagnosis
National Cancer Institute
6130 Executive Boulevard, EPN Room 7009, MSC 7432
Bethesda, MD 20892-7432
Phone: 301-496-8866
FAX: 301-480-4663

Jerome R. Wujek, Ph.D.
Research Resources Officer
Division of Extramural Research
National Eye Institute
National Institutes of Health
Suite 1300
5635 Fishers Lane, MSC 9300
Bethesda, MD  20892-9300
Phone:  301-451-2020
FAX:  301-402-0528

Wen G. Chen, Ph.D. 
Program Director
Sensory and Motor Disorders of Aging
Behavioral & Systems Neuroscience Branch
Division of Neuroscience
National Institute on Aging/NIH/DHHS
7201 Wisconsin Avenue
Bethesda, MD  20892-9205
Phone:  301-496-9350
FAX:  301-496-1494

John W. Haller, PhD
Liaison for International Activities
National Institute of Biomedical Imaging and Bioengineering
6707 Democracy Blvd. Suite 200
Bethesda, MD 20892-5649
Phone: 301-451-4780
FAX: 301-480-1614

Nancy L. Shinowara, PhD
Program Director, Spinal Cord and Musculoskeletal Disorders and Assistive Devices
National Center for Medical Rehabilitation Research
National Institute of Child Health and Human Development
6100 Executive Blvd. Room 2A03 MSC7510
Bethesda, MD 20892-7510 (for courier delivery use: Rockville, MD 20852)
Phone: 301-402-2242
FAX: 301-402-0832

Christine Colvis, Ph.D.
Genetics & Molecular Neurobiology Research
National Institute on Drug Abuse
6001 Executive Blvd, Room 4282
Bethesda, MD 20892
Phone: 301-435-1323
FAX: 301-594-6043

Barry Davis, Ph.D.
Division of Scientific Programs
National Institute on Deafness and Other Communication Disorders
6120 Executive Boulevard, EPS Room 400C, MSC-7180
Bethesda, MD  20892-7180
Phone: 301-402-3464
FAX: 301-402-6251

Annette Kirshner, PhD
Program Administrator
Cells and Organ Systems Pathobiology Branch
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
Box 12233  KE 3020 MD K3-15
Research Triangle Park, NC 27713
Phone: 919-541-0488
FAX: 919-541-0462

Margaret Grabb, Ph.D.
National Institute of Mental Health
6001 Executive Blvd., Room 7201
Mail Stop Code 9645
Bethesda, MD 20892
Phone: 301- 443-3563
FAX: 301-443-1731

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