Notice Number: NOT-NS-05-012
Release Date: September 2, 2005
National Institute of Neurological Disorders and Stroke (NINDS), (http://www.ninds.nih.gov)
The National Institute of Neurological Disorders and Stroke (NINDS) is considering issuing a contract for preclinical studies of new or improved pharmaceutical preparations to be used as medical countermeasures against chemical agents that could be used in a terrorist attack. As a first step, the Institute is attempting to identify expert sources to conduct safety, pharmacokinetic/biodistribution, and developmental chemistry studies with candidate drugs.
The increased risk of a terrorist attack in the U.S. involving chemical agents has created new challenges for many departments and agencies across the federal government. Within the Department of Health and Human Services (DHHS), the NIH is leading the development of new and improved therapeutics designed to treat the conditions caused by potential chemical agents of terrorism. The NIH Chemical Threats program is part of the larger biodefense program coordinated by the NIAID that includes Biological and Radiation/Nuclear threats.
Our intent is to fund a preclinical testing facility that will conduct safety, pharmacokinetic/biodistribution, and developmental chemistry studies with candidate drugs. The preclinical testing facility will not conduct any efficacy studies with drugs, or any studies with the chemical agents themselves. Candidate drugs that will be tested in this facility will have been previously shown to be efficacious by studies conducted within other NINDS programs that utilize models for, or actual, chemical agents. Candidate drugs will be supplied to the contractor by the NINDS.
This facility would provide several functions:
Types of potential facilities
Information in the following areas will aid in the design of solicitations for a preclinical test facility. The information supplied in any response to this request should address, but not be limited to, the following (Three Page Limit):
This Request for Information (RFI) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the Government. The Government does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted or the Government's use of such information. Acknowledgment of receipt of responses will not be made, nor will respondents be notified of the Government's evaluation of the information received. However, should such a requirement materialize, no basis for claims against the Government shall arise as a result of a response to this request for information or the Government's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. Responses will be held in a confidential manner. Any proprietary information should be so marked.
All respondents are asked to indicate the type and size of your business or organization, e.g., Large Business, Small Business, Hubzone Small Business, Small Disadvantaged Business, Women-Owned Business, 8(a), Historically Black College or University/Minority Institution (HBCU/MI), educational institution, profit/non-profit hospital, or other non-profit organization.
Responses should be identified with RFI No. NOT-NS-05-012, and are due by September 19, 2005. Please submit three (3) copies of your response, to Helene Braun, Contract Specialist, Contracts Management Branch, National Institute of Neurological Disorders and Stroke, NIH, 6001 Executive Boulevard, Room 3287, Bethesda, MD 20892-9531 (For Fedex or courier, use: Rockville, MD 20852). Email responses will also be accepted at firstname.lastname@example.org.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
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