NINDS ADMINISTRATIVE SUPPLEMENTS FOR THE SHARING AND DISTRIBUTION OF
MOUSE GENETIC MODELS
RELEASE DATE: March 23, 2004
NOTICE: NOT-NS-04-009
National Institute of Neurological Disorders and Stroke (NINDS)
(http://www.ninds.nih.gov/)
The National Institute of Neurological Disorders and Stroke (NINDS)
announces the reissue of an administrative supplement program designed
to support and encourage the timely sharing of mouse genetic models (or
other rodent genetic lines) included within the scope of currently
funded NINDS research projects. The sharing of data, biomaterials and
other unique research resources such as genetically modified mouse
strains is an essential element in the rapid progress that has been
made in the genetic analysis of neurological disorders and complex
behavioral traits (also refer to
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-035.html).
Unimpeded access to these valuable resources not only benefits the
scientific community as a whole, but also avoids unnecessary
duplication of expensive efforts to generate mouse models with targeted
genetic changes. This supplemental funding initiative is issued in
response to the NIH Grants Policy Statement requiring investigators to
provide prompt and effective access to unique research resources
generated by NIH funds
(http://grants.nih.gov/grants/policy/nihgps_2001/) and the NINDS
Strategic Plan to supplement the costs of distributing these resources
(http://www.ninds.nih.gov/about_ninds/plans/strategic_plan.htm -
Infrastructure). These one-time supplements are intended to assist the
donor laboratory with the costs of distributing mouse genetic lines to
other investigators in the scientific community. The costs associated
with creating, acquiring and/or characterizing these mouse models (by
either the mouse donor or recipient laboratory) are not within the
scope of this program.
Principal Investigators (PIs) with NINDS funded Research Project (R01),
Research Project - Cooperative Agreement (U01), Research Program
Project (P01), Specialized Center (P50) and Specialized Center
Cooperative Agreement (U54) grants are eligible to apply; for P01, P50
and U54 multi-project grants, the overall project PI must submit the
request for a supplement. To be eligible, the donor's NINDS-funded
project must have at least one year of funding remaining on the parent
grant at the time of receipt of the supplement application (a no-cost
extension beyond that date does not confer eligibility; see below for
specific dates). Allowable expenses include estimated shipping and
handling costs, veterinary costs and serology testing involved in the
process of distributing the mice, and the portion of breeding,
genotyping, personnel and animal housing costs required to maintain the
colony explicitly for the purposes of sharing. The PI may not
additionally charge the recipient's laboratory for any of these
budgeted expenses.
Application Procedures: Send the original and 5 copies of the complete
supplement application to Dr. Danilo Tagle (see below) by one of the
two receipt deadlines listed below. The request for the supplemental
award MUST include the following:
1. An ORIGINAL completed face page (not the face page of the parent
grant), including appropriate signatures, from Grant Application Form
PHS 398 (updated 9/09/03; http://grants.nih.gov/grants/forms.htm).
Include the title and grant number of the parent grant on line 1 and
enter "NOT-NS-04-009" (Number) and "NINDS Administrative Supplements
for the Sharing and Distribution of Mouse Genetic Models" (Title) on
line 2. Document the approval from the Institutional Animal Care and
Use Committee (IACUC) on the included mouse strain(s) in section 5 of
the face page.
2. An itemized budget entered on the budget pages from Grant
Application Form PHS 398; although the awarded budgets will be modular,
applicants should provide a budget justification that details the
budget items requested including Facilities and Administrative costs
(see Budget Information below).
3. A description of how the mouse model(s) relates to the scope and
Specific Aims of the parent grant (maximum 2 pages).
4. An updated NIH-formatted Biographical Sketch of the PI, if revised
since original submission of the parent grant.
5. A description of the mouse strain(s) and documentation of
anticipated demand (see Review Criteria below; maximum 5 pages).
6. A copy of the Material Transfer Agreement (MTA) form, if any are to
be used, governing transfer of the mouse line(s) from the donor's
institution to recipient institutions (e.g., the Simple Letter
Agreement (SLA) or UBMTA). In addition, explain any additional
restrictions in the Animal Transfer Agreement governing transfer of the
mice from donor to the recipient laboratory beyond what is included in
a standard NIH Animal Transfer Agreement (see
http://oacu.od.nih.gov/ARAC/transfer.htm).
Budget information: These one-time supplements will be awarded as
TOTAL COSTS (includes both Direct Costs AND Facilities and
Administrative costs) in modular amounts of $10,000, with a maximum
request of $50,000 for R01 or U01 grants and $100,000 for P01, P50 or
U54 grants. Any Facilities and Administrative (F&A) Costs should be
included in the modular request and may not be added to it. The NINDS
will commit $500,000 (Total Costs) in FY05 fund applications for
supplements submitted in response to this Notice.
Review Criteria: Applications will be reviewed administratively, and
it is expected that the notice of award will be issued within
approximately three months of the receipt deadline. All funding
decisions are final and are not subject to appeal. Applicants should
provide the following information for consideration in review:
1. A brief description of the mouse model including information
pertinent to the genotype (e.g., targeting constructs, background
strain, etc.) and phenotype of the mouse strain(s); list any relevant
publications describing the construction, genotype, phenotype, etc. of
the mouse strain(s).
2. A description of the value of the mouse model to the neuroscience
community with regard to its role in elucidating mechanisms of
neurological function or disease.
3. Evidence of the demand for the mouse strain(s) during the past
year, including the names of all previous requestors, their
institution, the date of the request, the specific mouse strain
requested and the reason for the request (include whether the request
involved an independent line of research by the requestor or a
collaboration with the PI). Indicate whether or not the requested mice
were sent out and, if so, how many, and the specific nature of the
expenses involved in distributing the mice in the past year (please
note, however, that the supplement itself is not intended to be
retroactive for expenses incurred in the past year).
4. A description of the viability and breeding potential of the mouse
line(s).
5. Justification and documentation of the requested budget for future
anticipated expenses.
6. A description of how the requests for mouse shipments will be
prioritized, in the event that demand exceeds the allocated funds.
Acceptance of a supplemental award under this announcement requires the
following:
1. Consent to include information and other relevant data on the mouse
model (supplied by the PI) in an NINDS-or NIH-supported web database of
mouse genetic models, if requested by the NINDS.
2. Consent, to the extent not already provided, to distribute the
mouse model(s) through a national public repository (e.g.,
http://www.jax.org/; http://www.mmrrc.org/), as applicable and
requested by the NINDS.
3. A brief progress report listing all requests and shipments of the
mouse line(s) during the supplement funding period. Include recipient
investigator and institution, date of the request, nature of the
request (include whether the request/shipment involved an independent
line of research by the requestor or a collaboration with the PI), date
of shipment and number of mice shipped, actual costs of the
distribution, and any problems encountered in the process of
disseminating the mice. This should be included with the progress
report of the parent grant, following the conclusion of the
supplemental award.
Receipt Dates: There are two receipt dates for this supplemental
program.
The parent grant must have at least one year of funding remaining at
the time of supplement application, as indicated by the Project Period
End Date of the parent grant (see below).
Project Period End Date
Supplement Receipt Dates: of the parent grant:
July 30, 2004 July 30, 2005 or later
May 27, 2005 May 27, 2006 or later
Direct inquiries regarding scientific/programmatic issues to one of the
following individuals:
Danilo A. Tagle, Ph.D.
Program Director, Neurogenetics
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2133
6001 Executive Boulevard
Bethesda, MD 20892-9527
(courier/express delivery: Rockville, MD 20852-9527)
Tel: 301-496-5745; Fax: 301-402-1501
Email: tagled@ninds.nih.gov
Laura A. Mamounas, Ph.D.
Program Director, Neurogenetics
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2132
6001 Executive Boulevard
Bethesda, MD 20892-9525
(courier/express delivery: Rockville, MD 20852-9525)
Tel: 301-496-5745; Fax: 301-402-1501
Email: mamounas@ninds.nih.gov
Direct inquiries regarding fiscal or grants management matters to:
Sheila Simmons
Grants Management Branch
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard, NSC-3290
Bethesda, Maryland 20892
Tel: 301-496-9231; Fax: 301-402-0219
Email: simmonss@ninds.nih.gov
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