NINDS ADMINISTRATIVE SUPPLEMENTS FOR THE SHARING AND DISTRIBUTION OF MOUSE GENETIC MODELS RELEASE DATE: March 23, 2004 NOTICE: NOT-NS-04-009 National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov/) The National Institute of Neurological Disorders and Stroke (NINDS) announces the reissue of an administrative supplement program designed to support and encourage the timely sharing of mouse genetic models (or other rodent genetic lines) included within the scope of currently funded NINDS research projects. The sharing of data, biomaterials and other unique research resources such as genetically modified mouse strains is an essential element in the rapid progress that has been made in the genetic analysis of neurological disorders and complex behavioral traits (also refer to http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-035.html). Unimpeded access to these valuable resources not only benefits the scientific community as a whole, but also avoids unnecessary duplication of expensive efforts to generate mouse models with targeted genetic changes. This supplemental funding initiative is issued in response to the NIH Grants Policy Statement requiring investigators to provide prompt and effective access to unique research resources generated by NIH funds (http://grants.nih.gov/grants/policy/nihgps_2001/) and the NINDS Strategic Plan to supplement the costs of distributing these resources (http://www.ninds.nih.gov/about_ninds/plans/strategic_plan.htm - Infrastructure). These one-time supplements are intended to assist the donor laboratory with the costs of distributing mouse genetic lines to other investigators in the scientific community. The costs associated with creating, acquiring and/or characterizing these mouse models (by either the mouse donor or recipient laboratory) are not within the scope of this program. Principal Investigators (PIs) with NINDS funded Research Project (R01), Research Project - Cooperative Agreement (U01), Research Program Project (P01), Specialized Center (P50) and Specialized Center Cooperative Agreement (U54) grants are eligible to apply; for P01, P50 and U54 multi-project grants, the overall project PI must submit the request for a supplement. To be eligible, the donor's NINDS-funded project must have at least one year of funding remaining on the parent grant at the time of receipt of the supplement application (a no-cost extension beyond that date does not confer eligibility; see below for specific dates). Allowable expenses include estimated shipping and handling costs, veterinary costs and serology testing involved in the process of distributing the mice, and the portion of breeding, genotyping, personnel and animal housing costs required to maintain the colony explicitly for the purposes of sharing. The PI may not additionally charge the recipient's laboratory for any of these budgeted expenses. Application Procedures: Send the original and 5 copies of the complete supplement application to Dr. Danilo Tagle (see below) by one of the two receipt deadlines listed below. The request for the supplemental award MUST include the following: 1. An ORIGINAL completed face page (not the face page of the parent grant), including appropriate signatures, from Grant Application Form PHS 398 (updated 9/09/03; http://grants.nih.gov/grants/forms.htm). Include the title and grant number of the parent grant on line 1 and enter "NOT-NS-04-009" (Number) and "NINDS Administrative Supplements for the Sharing and Distribution of Mouse Genetic Models" (Title) on line 2. Document the approval from the Institutional Animal Care and Use Committee (IACUC) on the included mouse strain(s) in section 5 of the face page. 2. An itemized budget entered on the budget pages from Grant Application Form PHS 398; although the awarded budgets will be modular, applicants should provide a budget justification that details the budget items requested including Facilities and Administrative costs (see Budget Information below). 3. A description of how the mouse model(s) relates to the scope and Specific Aims of the parent grant (maximum 2 pages). 4. An updated NIH-formatted Biographical Sketch of the PI, if revised since original submission of the parent grant. 5. A description of the mouse strain(s) and documentation of anticipated demand (see Review Criteria below; maximum 5 pages). 6. A copy of the Material Transfer Agreement (MTA) form, if any are to be used, governing transfer of the mouse line(s) from the donor's institution to recipient institutions (e.g., the Simple Letter Agreement (SLA) or UBMTA). In addition, explain any additional restrictions in the Animal Transfer Agreement governing transfer of the mice from donor to the recipient laboratory beyond what is included in a standard NIH Animal Transfer Agreement (see http://oacu.od.nih.gov/ARAC/transfer.htm). Budget information: These one-time supplements will be awarded as TOTAL COSTS (includes both Direct Costs AND Facilities and Administrative costs) in modular amounts of $10,000, with a maximum request of $50,000 for R01 or U01 grants and $100,000 for P01, P50 or U54 grants. Any Facilities and Administrative (F&A) Costs should be included in the modular request and may not be added to it. The NINDS will commit $500,000 (Total Costs) in FY05 fund applications for supplements submitted in response to this Notice. Review Criteria: Applications will be reviewed administratively, and it is expected that the notice of award will be issued within approximately three months of the receipt deadline. All funding decisions are final and are not subject to appeal. Applicants should provide the following information for consideration in review: 1. A brief description of the mouse model including information pertinent to the genotype (e.g., targeting constructs, background strain, etc.) and phenotype of the mouse strain(s); list any relevant publications describing the construction, genotype, phenotype, etc. of the mouse strain(s). 2. A description of the value of the mouse model to the neuroscience community with regard to its role in elucidating mechanisms of neurological function or disease. 3. Evidence of the demand for the mouse strain(s) during the past year, including the names of all previous requestors, their institution, the date of the request, the specific mouse strain requested and the reason for the request (include whether the request involved an independent line of research by the requestor or a collaboration with the PI). Indicate whether or not the requested mice were sent out and, if so, how many, and the specific nature of the expenses involved in distributing the mice in the past year (please note, however, that the supplement itself is not intended to be retroactive for expenses incurred in the past year). 4. A description of the viability and breeding potential of the mouse line(s). 5. Justification and documentation of the requested budget for future anticipated expenses. 6. A description of how the requests for mouse shipments will be prioritized, in the event that demand exceeds the allocated funds. Acceptance of a supplemental award under this announcement requires the following: 1. Consent to include information and other relevant data on the mouse model (supplied by the PI) in an NINDS-or NIH-supported web database of mouse genetic models, if requested by the NINDS. 2. Consent, to the extent not already provided, to distribute the mouse model(s) through a national public repository (e.g., http://www.jax.org/; http://www.mmrrc.org/), as applicable and requested by the NINDS. 3. A brief progress report listing all requests and shipments of the mouse line(s) during the supplement funding period. Include recipient investigator and institution, date of the request, nature of the request (include whether the request/shipment involved an independent line of research by the requestor or a collaboration with the PI), date of shipment and number of mice shipped, actual costs of the distribution, and any problems encountered in the process of disseminating the mice. This should be included with the progress report of the parent grant, following the conclusion of the supplemental award. Receipt Dates: There are two receipt dates for this supplemental program. The parent grant must have at least one year of funding remaining at the time of supplement application, as indicated by the Project Period End Date of the parent grant (see below). Project Period End Date Supplement Receipt Dates: of the parent grant: July 30, 2004 July 30, 2005 or later May 27, 2005 May 27, 2006 or later Direct inquiries regarding scientific/programmatic issues to one of the following individuals: Danilo A. Tagle, Ph.D. Program Director, Neurogenetics National Institute of Neurological Disorders and Stroke Neuroscience Center, Room 2133 6001 Executive Boulevard Bethesda, MD 20892-9527 (courier/express delivery: Rockville, MD 20852-9527) Tel: 301-496-5745; Fax: 301-402-1501 Email: tagled@ninds.nih.gov Laura A. Mamounas, Ph.D. Program Director, Neurogenetics National Institute of Neurological Disorders and Stroke Neuroscience Center, Room 2132 6001 Executive Boulevard Bethesda, MD 20892-9525 (courier/express delivery: Rockville, MD 20852-9525) Tel: 301-496-5745; Fax: 301-402-1501 Email: mamounas@ninds.nih.gov Direct inquiries regarding fiscal or grants management matters to: Sheila Simmons Grants Management Branch National Institute of Neurological Disorders and Stroke 6001 Executive Boulevard, NSC-3290 Bethesda, Maryland 20892 Tel: 301-496-9231; Fax: 301-402-0219 Email: simmonss@ninds.nih.gov


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