NINDS ADMINISTRATIVE SUPPLEMENTS FOR THE SHARING AND DISTRIBUTION OF MOUSE
GENETIC MODELS
Release Date: April 26, 2002
NOTICE: NOT-NS-02-013
National Institute of Neurological Disorders and Stroke (NINDS)
(http://www.ninds.nih.gov/)
The National Institute of Neurological Disorders and Stroke (NINDS) announces
an administrative supplement program designed to support and encourage the
timely sharing of mouse genetic models (or other rodent genetic lines)
included within the scope of currently funded NINDS research projects. The
sharing of data, biomaterials and other unique research resources such as
genetically modified mouse strains is an essential element in the rapid
progress that has been made in the genetic analysis of neurological disorders
and complex behavioral traits (also refer to
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-035.html).
Unimpeded access to these valuable resources not only benefits the scientific
community as a whole, but also avoids unnecessary duplication of expensive
efforts to generate mouse models with targeted genetic changes. This
supplemental funding initiative is issued in response to the NIH Grants
Policy Statement requiring investigators to provide prompt and effective
access to unique research resources generated by NIH funds
(http://grants.nih.gov/grants/policy/nihgps_2001/) and the NINDS Strategic
Plan to supplement the costs of distributing these resources
(http://www.ninds.nih.gov/about_ninds/plans/strategic_plan.htm - Infrastructure).
These one-time supplements are intended to assist the donor laboratory with
the costs of disseminating mouse genetic lines to other investigators in the
scientific community. The costs associated with creating, acquiring and/or
characterizing these mouse models (by either the mouse donor or recipient
laboratory) are not within the scope of this program.
Principal Investigators (PIs) with NINDS funded Research Project (R01),
Research Program Project (P01), Specialized Center (P50) and Specialized
Center Cooperative Agreement (U54) grants are eligible to apply, for P01,
P50 and U54 grants, the overall project PI must submit the request for a
supplement. To be eligible, the donor"s NINDS-funded project must have at
least one year of funding remaining on the parent grant at the time of
receipt of the supplement application (a no-cost extension beyond that date
does not confer eligibility, see below for specific dates). Allowable
expenses include estimated shipping and handling costs, veterinary costs and
serology testing involved in the process of distributing the mice, and the
portion of breeding, genotyping, personnel and animal housing costs required
to maintain the colony explicitly for the purposes of sharing. The PI may
not additionally charge the recipient"s laboratory for any of these budgeted
expenses.
Application Procedures: Send the original and 5 copies of the complete
supplement application to Dr. Danilo Tagle (see below) by one of the three
receipt deadlines listed below. The request for the supplemental award MUST
include the following:
1. An ORIGINAL completed face page (not the face page of the parent grant),
including appropriate signatures, from Grant Application Form PHS 398
(updated 1/25/02, http://grants.nih.gov/grants/forms.htm). Include the
title and grant number of the parent grant on line 1 and enter "NOT-NS-02-
013" (Number) and "NINDS Administrative Supplements for the Sharing and
Distribution of Mouse Genetic Models" (Title) on line 2. Document the
approval from the Institutional Animal Care and Use Committee (IACUC) on the
included mouse strain(s) in section 5 of the face page.
2. An itemized budget entered on the budget pages from Grant Application
Form PHS 398, although the awarded budgets will be modular, applicants should
provide a budget justification that details the budget items requested
including Facilities and Administrative costs (see Budget Information below).
3. A description of how the mouse model(s) relates to the scope and Specific
Aims of the parent grant (maximum 2 pages).
4. An updated NIH-formatted Biographical Sketch of the PI, if revised since
original submission of the parent grant.
5. A description of the mouse strain(s) and documentation of anticipated
demand (see Review Criteria below, maximum 5 pages).
6. A copy of the Material Transfer Agreement form governing transfer of the
mouse line(s) from the donor"s institution to a recipient institution,
explain any additional restrictions to the recipient laboratory beyond what
is included in a standard NIH Animal Transfer Agreement (see
http://oacu.od.nih.gov/ARAC/transfer.htm).
Budget information: These one-time supplements will be awarded as TOTAL
COSTS (includes both Direct Costs AND Facilities and Administrative costs) in
modular amounts of $10,000, with a maximum request of $50,000 for R01 grants
and $100,000 for P01, P50 or U54 grants. Any Facilities and Administrative
(F&A) Costs should be included in the modular request and may not be added to
it. The NINDS will commit $1.4 million (Total Costs) in FY02 and FY03 to
fund applications for supplements submitted in response to this Notice.
Review Criteria: Applications will be reviewed administratively, and it is
expected that the notice of award will be issued within approximately three
months of the receipt deadline. All funding decisions are final and are not
subject to appeal. Applicants should provide the following information for
consideration in review:
1. A brief description of the mouse model including information pertinent to
the genotype (e.g., targeting constructs, background strain, etc.) and
phenotype of the mouse strain(s), list any relevant publications describing
the construction, genotype, phenotype, etc. of the mouse strain(s).
2. A description of the value of the mouse model to the neuroscience
community with regard to its role in elucidating mechanisms of neurological
function or disease.
3. Evidence of the demand for the mouse strain(s) during the past year,
including the names of all previous requestors, their institution, the date
of the request, the specific mouse strain requested and the reason for the
request (include whether the request involved an independent line of research
by the requestor or a collaboration with the PI). Indicate whether or not
the requested mice were sent out and, if so, how many, and the specific
nature of the expenses involved in distributing the mice in the past year
(please note, however, that the supplement itself is not intended to be
retroactive for expenses incurred in the past year).
4. A description of the viability and breeding potential of the mouse
line(s).
5. Justification and documentation of the requested budget for future
anticipated expenses.
6. A description of how the requests for mouse shipments will be
prioritized, in the event that demand exceeds the allocated funds.
Acceptance of a supplemental award under this announcement requires the
following:
1. Consent to include information and other relevant data on the mouse model
(supplied by the PI) in an NINDS-or NIH-supported web database of mouse
genetic models, if requested by the NINDS.
2. Consent to distribute the mouse model through a national public
repository (e.g., http://www.jax.org, http://www.mmrrc.org), if applicable
and requested by the NINDS.
3. A brief progress report listing all requests and shipments of the mouse
line(s) during the supplement funding period. Include recipient investigator
and institution, date of the request, nature of the request (include whether
the request/shipment involved an independent line of research by the
requestor or a collaboration with the PI), date of shipment and number of
mice shipped, actual costs of the distribution, and any problems encountered
in the process of disseminating the mice. This should be included with the
progress report of the parent grant, following the conclusion of the
supplemental award.
Receipt Dates: There are three receipt dates for this supplemental program.
The parent grant must have at least one year of funding remaining at the time
of supplement application, as indicated by the Project Period End Date of the
parent grant (see below).
Project Period End Date
Supplement Receipt Dates: of the parent grant:
July 15, 2002 July 15, 2003 or later
December 16, 2002 December 16, 2003 or later
May 16, 2003 May 16, 2004 or later
Direct inquiries regarding scientific/programmatic issues to one of the
following individuals:
Danilo A. Tagle, Ph.D.
Program Director, Neurogenetics
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2133
6001 Executive Boulevard
Bethesda, MD 20892-9527
(courier/express delivery: Rockville, MD 20852-9527)
Tel: 301-496-5745, Fax: 301-402-1501
Email: tagled@ninds.nih.gov
Laura A. Mamounas, Ph.D.
Program Director, Repair & Plasticity
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2206
6001 Executive Boulevard
Bethesda, MD 20892-9525
(courier/express delivery: Rockville, MD 20852-9525)
Tel: 301-496-1447, Fax: 301-480-1080
Email: mamounas@ninds.nih.gov
Direct inquiries regarding fiscal or grants management matters to:
Rebecca Claycamp
Grants Management Branch
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard, NSC-3290
Bethesda, Maryland 20892
Tel: 301-496-9231, Fax: 301-402-0219
Email: rc253d@nih.gov
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