NINDS ADMINISTRATIVE SUPPLEMENTS FOR THE SHARING AND DISTRIBUTION OF MOUSE 
GENETIC MODELS

Release Date:  April 26, 2002

NOTICE:  NOT-NS-02-013

National Institute of Neurological Disorders and Stroke (NINDS) 
 (http://www.ninds.nih.gov/)

The National Institute of Neurological Disorders and Stroke (NINDS) announces 
an administrative supplement program designed to support and encourage the 
timely sharing of mouse genetic models (or other rodent genetic lines) 
included within the scope of currently funded NINDS research projects.  The 
sharing of data, biomaterials and other unique research resources such as 
genetically modified mouse strains is an essential element in the rapid 
progress that has been made in the genetic analysis of neurological disorders 
and complex behavioral traits (also refer to 
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-035.html).  
Unimpeded access to these valuable resources not only benefits the scientific 
community as a whole, but also avoids unnecessary duplication of expensive 
efforts to generate mouse models with targeted genetic changes.  This 
supplemental funding initiative is issued in response to the NIH Grants 
Policy Statement requiring investigators to provide prompt and effective 
access to unique research resources generated by NIH funds 
(http://grants.nih.gov/grants/policy/nihgps_2001/) and the NINDS Strategic 
Plan to supplement the costs of distributing these resources 
(http://www.ninds.nih.gov/about_ninds/plans/strategic_plan.htm - Infrastructure).  
These one-time supplements are intended to assist the donor laboratory with 
the costs of disseminating mouse genetic lines to other investigators in the 
scientific community.  The costs associated with creating, acquiring and/or 
characterizing these mouse models (by either the mouse donor or recipient 
laboratory) are not within the scope of this program.  

Principal Investigators (PIs) with NINDS funded Research Project (R01), 
Research Program Project (P01), Specialized Center (P50) and Specialized 
Center – Cooperative Agreement (U54) grants are eligible to apply, for P01, 
P50 and U54 grants, the overall project PI must submit the request for a 
supplement.  To be eligible, the donor"s NINDS-funded project must have at 
least one year of funding remaining on the parent grant at the time of 
receipt of the supplement application (a no-cost extension beyond that date 
does not confer eligibility, see below for specific dates).  Allowable 
expenses include estimated shipping and handling costs, veterinary costs and 
serology testing involved in the process of distributing the mice, and the 
portion of breeding, genotyping, personnel and animal housing costs required 
to maintain the colony explicitly for the purposes of sharing.  The PI may 
not additionally charge the recipient"s laboratory for any of these budgeted 
expenses.

Application Procedures:  Send the original and 5 copies of the complete 
supplement application to Dr. Danilo Tagle (see below) by one of the three 
receipt deadlines listed below.  The request for the supplemental award MUST 
include the following:

1.  An ORIGINAL completed face page (not the face page of the parent grant), 
including appropriate signatures, from Grant Application Form PHS 398 
(updated 1/25/02, http://grants.nih.gov/grants/forms.htm).  Include the 
title and grant number of the parent grant on line 1 and enter "NOT-NS-02-
013" (Number) and "NINDS Administrative Supplements for the Sharing and 
Distribution of Mouse Genetic Models" (Title) on line 2.  Document the 
approval from the Institutional Animal Care and Use Committee (IACUC) on the 
included mouse strain(s) in section 5 of the face page.
2.  An itemized budget entered on the budget pages from Grant Application 
Form PHS 398, although the awarded budgets will be modular, applicants should 
provide a budget justification that details the budget items requested 
including Facilities and Administrative costs (see Budget Information below).
3.  A description of how the mouse model(s) relates to the scope and Specific 
Aims of the parent grant (maximum 2 pages).
4.  An updated NIH-formatted Biographical Sketch of the PI, if revised since 
original submission of the parent grant.
5.  A description of the mouse strain(s) and documentation of anticipated 
demand (see Review Criteria below, maximum 5 pages).
6.  A copy of the Material Transfer Agreement form governing transfer of the 
mouse line(s) from the donor"s institution to a recipient institution, 
explain any additional restrictions to the recipient laboratory beyond what 
is included in a standard NIH Animal Transfer Agreement (see 
http://oacu.od.nih.gov/ARAC/transfer.htm).

Budget information:  These one-time supplements will be awarded as TOTAL 
COSTS (includes both Direct Costs AND Facilities and Administrative costs) in 
modular amounts of $10,000, with a maximum request of $50,000 for R01 grants 
and $100,000 for P01, P50 or U54 grants.  Any Facilities and Administrative 
(F&A) Costs should be included in the modular request and may not be added to 
it.  The NINDS will commit $1.4 million (Total Costs) in FY02 and FY03 to 
fund applications for supplements submitted in response to this Notice.

Review Criteria:  Applications will be reviewed administratively, and it is 
expected that the notice of award will be issued within approximately three 
months of the receipt deadline.  All funding decisions are final and are not 
subject to appeal.  Applicants should provide the following information for 
consideration in review: 

1.  A brief description of the mouse model including information pertinent to 
the genotype (e.g., targeting constructs, background strain, etc.) and 
phenotype of the mouse strain(s), list any relevant publications describing 
the construction, genotype, phenotype, etc. of the mouse strain(s).
2.  A description of the value of the mouse model to the neuroscience 
community with regard to its role in elucidating mechanisms of neurological 
function or disease.
3.  Evidence of the demand for the mouse strain(s) during the past year, 
including the names of all previous requestors, their institution, the date 
of the request, the specific mouse strain requested and the reason for the 
request (include whether the request involved an independent line of research 
by the requestor or a collaboration with the PI).  Indicate whether or not 
the requested mice were sent out and, if so, how many, and the specific 
nature of the expenses involved in distributing the mice in the past year 
(please note, however, that the supplement itself is not intended to be 
retroactive for expenses incurred in the past year).
4.  A description of the viability and breeding potential of the mouse 
line(s). 
5.  Justification and documentation of the requested budget for future 
anticipated expenses.
6.  A description of how the requests for mouse shipments will be 
prioritized, in the event that demand exceeds the allocated funds.

Acceptance of a supplemental award under this announcement requires the 
following:  

1.  Consent to include information and other relevant data on the mouse model 
(supplied by the PI) in an NINDS-or NIH-supported web database of mouse 
genetic models, if requested by the NINDS. 
2.  Consent to distribute the mouse model through a national public 
repository (e.g., http://www.jax.org, http://www.mmrrc.org), if applicable 
and requested by the NINDS. 
3.  A brief progress report listing all requests and shipments of the mouse 
line(s) during the supplement funding period.  Include recipient investigator 
and institution, date of the request, nature of the request (include whether 
the request/shipment involved an independent line of research by the 
requestor or a collaboration with the PI), date of shipment and number of 
mice shipped, actual costs of the distribution, and any problems encountered 
in the process of disseminating the mice.  This should be included with the 
progress report of the parent grant, following the conclusion of the 
supplemental award.   

Receipt Dates:  There are three receipt dates for this supplemental program.  
The parent grant must have at least one year of funding remaining at the time 
of supplement application, as indicated by the Project Period End Date of the 
parent grant (see below).

                              Project Period End Date 
Supplement Receipt Dates:     of the parent grant:

July 15, 2002                 July 15, 2003 or later
December 16, 2002             December 16, 2003 or later
May 16, 2003                  May 16, 2004 or later

Direct inquiries regarding scientific/programmatic issues to one of the 
following individuals:

Danilo A. Tagle, Ph.D.
Program Director, Neurogenetics
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2133 
6001 Executive Boulevard
Bethesda, MD  20892-9527
(courier/express delivery: Rockville, MD  20852-9527)
Tel:  301-496-5745, Fax:  301-402-1501
Email:  tagled@ninds.nih.gov   

Laura A. Mamounas, Ph.D. 
Program Director, Repair & Plasticity
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 2206
6001 Executive Boulevard
Bethesda, MD  20892-9525
(courier/express delivery: Rockville, MD  20852-9525)
Tel: 301-496-1447, Fax: 301-480-1080
Email: mamounas@ninds.nih.gov

Direct inquiries regarding fiscal or grants management matters to:

Rebecca Claycamp
Grants Management Branch
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard, NSC-3290
Bethesda, Maryland  20892
Tel:  301-496-9231, Fax:  301-402-0219
Email:  rc253d@nih.gov


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