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*** REVISED *** NINDS TRAINING AND CAREER DEVELOPMENT PROGRAMS FOR CLINICAL SCIENTISTS Release Date: May 23, 2001 (Supercedes NOT-NS-01-008) NOTICE: NOT-NS-01-011 National Institute of Neurological Disorders and Stroke PURPOSE The National Institute of Neurological Disorders and Stroke (NINDS) is committed to the career development of clinically trained research scientists. At its September 2000 meeting, the National Advisory Neurological Disorders and Stroke (NANDS) Council approved an initiative to ensure the continued development of the clinician scientist research workforce in the neurological sciences. The goals of the initiative are to: (1) Encourage the interest of potential clinician scientists early in their education, (2) Accelerate entry to independent research, (3) Encourage translational research, and (4) Foster research training by especially competent laboratories. IMPORTANT NOTE: Several programs described in this Policy Notice are new and therefore are accompanied by specific program announcements that are being simultaneously published in this issue of the NIH Guide. A separate Policy Notice (NS-02-001) describing the new K-awards salary levels and research costs was published in the NIH Guide, May 9, 2001 (http://grants.nih.gov/grants/guide/notice-files/NOT-NS-02-001.html). These levels, which are reflected below, take effect for awards in FY 2002. Contributions to Research by Clinician Scientists: There are several ways in which clinician scientists contribute to the goal of reducing the burden of neurological disorders: (1) Recognition of basic science advances which could be pertinent to neurological disorders, (2) Using clinical observations to frame research design and strategy, (3) Conduct of translational, disease-focused research, designed to apply discoveries about basic neurobiology to the problems of neurological disorders, (4) Conduct of basic research and/or patient-oriented clinical research, (5) Assisting basic scientists in the design of studies related to human neurological illness, (6) Educating clinicians in the neurobiological basis of neurological disorders. Training and Career Development Programs for Clinician Scientists: The following programs provide a series of mechanism for different stages of training career development. These include: A. Programs designed for medical student training, B. Research fellowships before, during, and after residency training, and C. Post-residency clinician scientist career development awards. IMPORTANT NOTE: For detailed program descriptions and access to specific program announcements cited below, see the NINDS Training and Career Development website: http://www.ninds.nih.gov/funding/research_training.htm A. PROGRAMS DESIGNED FOR MEDICAL STUDENT TRAINING Medical Student Summer Research Program (T35): The goal of this short-term institutional training (T35) program is to encourage interest in clinical neuroscience and research. In conjunction with suitable mentoring, the program will inform students of clinical neuroscience careers, and educate them in patterns of research support. The program will be administered jointly by a neurology department and one or more basic science departments, and will require a clinical education component and a research career education component. The program is designed to produce highly competitive students to enter the Medical Student Scholars Program as well as the MD/PhD Fellowship program. A program announcement is being published in this issue of the NIH Guide. See: http://grants.nih.gov/grants/guide/pa-files/PA-01-098.html Medical Student Scholars Program (F31): The goal of this individual fellowship (F31) program is to encourage interest in clinical neuroscience, and to foster early and intensive research training. Programs for support of research during medical school will include 1-2 years of mentored research, beginning after 2 years of medical school. Training may occur at different sites in order to provide support for students who may be attending medical schools with comparatively less strength in basic or clinical neuroscience research. Strong mentoring is critical to the success of this program. The training is designed to provide extensive research experience during medical school to especially able candidates who are likely to pursue subsequent residency training in neurology or neurological surgery. The program will also support a national annual meeting to foster interactions and interest. A program announcement is being published in this issue of the NIH Guide. See: http://grants.nih.gov/grants/guide/pa-files/PA-01-099.html NINDS Medical Student Dual -Degree MD/PhD or MD/MPH Fellowships (F30): The enormous complexity of neurological sciences today prevents the standard course of study at most medical schools from providing the experience necessary to develop researchers. Since scientists who are both physicians and trained investigators play a vital role in helping to bring the highest scientific standards into basic and clinical research settings, this program is designed to combine training for the MD (or other clinical) degree with extensive research experience of the PhD degree. Examples of other clinical degrees include, but are not limited to D.O. and D.D.S. The NINDS F30 program is designed to help ensure that highly trained physician/scientists will be available in adequate numbers and in the appropriate research areas and fields to meet the Nation"s needs in neurological disorders research. The applicant must be enrolled in an MD program (or other clinical) at an approved medical/health professional school, accepted in a related scientific PhD or MPH program, and supervised by a mentor. The sponsoring institution must have staff and facilities available on site to provide a suitable environment for performing high-quality research training. The PhD or MPH phase of the program may be conducted outside of the sponsoring institution, e.g., Federal laboratory including the NIH intramural program. Support may be requested for up to 6 years. The NRSA stipends, tuition, and institutional support costs vary from year to year. A program announcement is being published in this issue of the NIH Guide. See: http://grants.nih.gov/grants/guide/pa-files/PA-01-100.html B. RESEARCH FELLOWSHIPS BEFORE, DURING, AND AFTER RESIDENCY TRAINING Individual National Research Service Postdoctoral Awards (F32): The F32 provides support for postdoctoral research training in the basic and clinical neurological sciences. The training plan should provide an opportunity for the trainees to broaden their research background or to extend their potential for research in neurological disorders. Prospective fellows must be accepted by a sponsor who will supervise the research and training experience. The setting may be academic or non-academic, including the NIH. The application must document that staff and facilities are available to provide a high-quality training opportunity. The application should emphasize opportunities for research training and broadening scientific competence. Applicants must agree to undertake a minimum of 2 years of biomedical research. The NRSA stipends, tuition, and institutional support costs vary from year to year. See: http://www.ninds.nih.gov/funding/research_training.htm NINDS Career Transition Award (K22): The goal of this program is to enable outstanding individuals to obtain a research training experience in the NINDS Division of Intramural Research (DIRP) and to facilitate their successful transition to an extramural environment as independent researchers. The award will provide 2-3 years of support for research training in the NINDS DIRP followed by 2-3 years of support for an independent research project in an extramural institution. The combined duration cannot exceed 5 years. It is anticipated that awardees will subsequently obtain research project grants such as the R01 to support the continuation of their work. To obtain support for the extramural phase, candidates must have a formal tenure-rack (or equivalent) offer in an extramural institution. During the extramural phase, the candidate must spend a minimum of 75% of full-time professional effort conducting research and research career development activities. Support during the intramural phase will include a fellowship stipend, based on the candidate"s years of postdoctoral experience and commensurate with the NINDS intramural salary structure. Up to $75,000 can be requested, plus research expenses (see program announcement). During the extramural support phase, the NINDS will provide salary for the award recipient of up to $85,000 per year, as well as research costs. The combined salary and research costs requested may not exceed $150,000 (direct costs). See: http://www.ninds.nih.gov/funding/research_training.htm C. POST-RESIDENCY CLINICIAN SCIENTIST CAREER DEVELOPMENT AWARDS Mentored Clinical Scientist Development Award (K08): The K08 is designed to recruit and prepare clinically trained persons for research careers in areas of basic or clinical science related to neurological disorders. The program will provide support for a period of mentored research for clinically trained individuals with strong potential to develop into outstanding basic or clinical research scientists. The program supports applicants who are within 3 years of completing their clinical training, which is defined as residency training, and if applicable, an additional year of clinical fellowship. The candidate must identify a mentor with extensive research experience and must devote at least 75% of his or her time and effort to research and career development activities. To accommodate neurosurgeons, who need significant clinical activity to maintain their surgical skills, NINDS will accept 50% time commitment to the award. This award will provide support for up to 5 years. The K08 award provides up to $85,000 per year of salary support, and up to $50,000 for research expenses. All mentored career development award recipients will be expected to attend an annual meeting designated by NINDS. See: http://www.ninds.nih.gov/funding/research_training.htm Mentored Patient-Oriented Research Career Development Award (K23): The K23 supports the career development of investigators who have made a commitment to focus their research endeavors on research in neurological disorders. This mechanism provides support for a period of supervised study and research for clinically trained professionals who have the potential to develop into productive clinical investigators focusing on patient-oriented research. The objective is to encourage research-oriented clinicians to develop independent research skills and gain experience in advanced methods and experimental approaches that will allow them to conduct patient-oriented research, and to capitalize on the discoveries of neuroscience research and translate them to clinical settings. Candidates must have completed their clinical training, including specialty and, if applicable, subspecialty training prior to receiving an award. Candidates must identify a mentor with extensive research experience and must be willing to spend a minimum of 75% of full-time professional effort in research career development and clinical research activities. Support under this award may extend to 5 years. The K23 award provides up to $85,000 per year of salary support, and up to $50,000 for research expenses. All mentored career development award recipients will be invited to attend an annual meeting at the NINDS. See: http://www.ninds.nih.gov/funding/research_training.htm Independent Scientist Award (K02): The K02 supports the development of clinically trained neuroscientists whose primary appointment is in a clinical department. This award provides specialized study opportunities for health professionals who are committed to a career in neuroscience research and have demonstrated their ability to conduct independent research. The candidate must devote a minimum of 75% of his or her time and effort to the proposed research and career development activities. Individuals holding positions of senior academic rank, such as associate professor or professor or the equivalent in non-academic settings, at the time of application are not eligible for a K02 award. This award will provide support for 5 years, however, the salary for the fourth and fifth year is awarded only if the applicant competes successfully for a regular research grant (R01). The K02 award provides up to $85,000 per year of salary support, and up to $50,000 for research expenses. See: http://www.ninds.nih.gov/funding/research_training.htm Midcareer Investigator Award in Patient-Oriented Research (K24): The K24 supports outstanding clinical scientists to allow them protected time to devote to research and to act as mentors for beginning clinical investigators. Candidates are expected to be generally within 15 years of their specialty training, with a demonstrated need for a period of intensive research focus as a means of enhancing their clinical research careers. Candidates must be committed to mentoring the next generation of clinical investigators focusing on patient-oriented research. Candidates must be willing to spend up to 50% effort (at least 25%) conducting research and mentoring more junior colleagues. Applicants must have independent research support at the time of application, and recipients of this award are required to hold independent research support during the period of this award. The project period may be up to 5 years (at least 3 are required). Awards are renewable for one additional 5-year period if the candidate still meets the stated requirements. The K24 award provides up to $80,600 (for 50% effort, based on the current NIH salary cap of $161,200) per year of salary support, and up to $25,000 for research expenses. See: http://www.ninds.nih.gov/funding/research_training.htm INQUIRIES For detailed program descriptions, application procedures, eligibility, and access to specific program announcements cited above, see the NINDS Training and Career Development website: http://www.ninds.nih.gov/funding/research_training.htm. Consultation with NINDS Program Staff is encouraged especially during the planning phase of the application. For a listing of NINDS Scientific areas and Program Staff contacts, see: http://www.ninds.nih.gov/funding/funding_announcements/funding_opps.htm NINDS Training and Career Development Officer National Institute of Neurological Disorders and Stroke 6001 Executive Boulevard, Room 2154, MSC 9531 Bethesda, MD 20892 Phone: (301) 496-4188 FAX: (301) 594-5929 Email: NINDSTrainingOffice@ninds.nih.gov
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