Release Date:  September 11, 2000 

NOTICE:  NS-00-011 (see Notice of Inactivation, NOT-NS-03-017)

National Institute of Neurological Disorders and Stroke


The National Institute of Neurological Disorders and Stroke (NINDS) 
invites applications for Exploratory/Developmental (R21) Grants 
relevant to its research mission. The R21 Grant mechanism is intended 
to support innovative, high impact research projects.  Such projects 
would either 1) generate pilot data to assess the feasibility of a 
novel avenue of investigation 2) involve high risk experiments that 
could lead to a breakthrough in a particular field or 3) demonstrate 
the feasibility of new technologies that could have major impact in a 
specific area.  To be eligible for consideration, proposals must be 
distinct from those traditionally submitted through the R01 mechanism.  
For example, projects designed to produce incremental advances in 
knowledge in a well-established area will not be considered.  Proposals 
submitted under this mechanism should be limited to those with the 
potential for truly ground-breaking impact.

Applicants for an R21 award may request direct costs of up to $125,000 
per year for a maximum of two years. This award is not renewable.  
Applications should be submitted on the grant application form PHS 398 
(rev. 4/98).  However, the Research Plan for an R21 proposal need not 
include preliminary data and should be limited to 15 pages (no 
appendices permitted).  Initial peer review will be conducted by the 
relevant study section in the NINDS Scientific Review Branch.   For 
further details regarding the R21 mechanism see the NINDS website:  Applicants are 
encouraged to contact appropriate program staff within NINDS for advice 
about potential R21 proposals. A complete listing of program director 
contacts may be found at:

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

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