Notice of NHLBI Participation in PAR-22-132 "Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low-and Middle-Income Countries and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional)"
Notice Number:
NOT-HL-22-035

Key Dates

Release Date:

July 5, 2022

Related Announcements

PAR-22-132 - Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low- and Middle-Income Countries (LMICs) and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional)

Issued by

National Heart, Lung, and Blood Institute (NHLBI)

Purpose

The purpose of this Notice is to inform potential applicants that the National Heart, Lung, and Blood Institute (NHLBI) is participating, effective immediately, in PAR-22-132 "Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low- and Middle-Income Countries (LMICs) and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional)."

The following sections of PAR-22-132 have been modified to highlight NHLBI's participation in this FOA:

Currently Reads:

Related Announcements

NOT-TW-21-008- Notice of Intent to Publish a Funding Opportunity Announcement for Implementation Research for Chronic Disease Prevention Across the Lifespan (R01 Clinical Trial Optional)

Issued by

Fogarty International Center (FIC)

National Eye Institute (NEI)

National Institute on Aging (NIA)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of Mental Health (NIMH)

National Institute of Neurological Disorders and Stroke (NINDS)

National Institute on Minority Health and Health Disparities (NIMHD)

National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Assistance Living Number(s)

93.989, 93.399, 93.113, 93.866, 93.865, 93.867, 93.279, 93.307, 93.853, 93.242

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

NIH IC-Specific Priorities Potential applicants are strongly encouraged to contact NIH IC program staff (listed below) early in the application process to discuss the alignment of their technical proposal with the goals of this FOA, the NIH IC, and the GACD program. NIH IC-specific priorities include the following:

Fogarty International Center (FIC)

NOTE:While the Fogarty International Center manages this program on behalf of NIH, FIC does not accept applications for this funding opportunity. Applications may only be submitted to partner ICs for funding consideration.

National Eye Institute (NEI)

The National Eye Institute supports basic and clinical research into diseases and disorders of the visual system and the special needs of people with impaired vision or who are blind. NEI is particularly interested in research of improved methods for delivering vision care and rehabilitation in underserved populations including people in urban and rural settings, especially those in AI/AN Tribal Nation populations in the United States. Research topics may include but are not limited to telemedicine, screening and automated diagnosis, medication adherence, quality of life, and rehabilitation strategies for those with vision loss.

NEI would only support clinical trial applications for this FOA that fulfill the NIH requirements for either a mechanistic or minimal risk trial. A mechanistic trial is designed to understand a biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention. A minimal risk trial is one in which the probability and magnitude of harm or discomfort anticipated in the research are not greater in and of themselves than those ordinarily encountered in daily life or during the performance of routine physical or psychological examinations or tests.

National Institute on Aging (NIA)

The National Institute on Aging mission is to support and conduct genetic, biological, clinical, behavioral, social, and economic research on aging; foster the development of research and clinician scientists in aging; provide research resources to facilitate innovative aging research; and disseminate information about aging and advances in research to the public, health care professionals, and the scientific community, among a variety of audiences.

NIA’s interest in this program is to support research to identify and understand barriers to the adoption, integration, scale-up, and sustainability of health interventions related to evidence-based practices to encourage healthy lifestyle behaviors related to life course aging and health, including Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), in LMICs and AI/AN Tribal Nation populations in the United States.

The NIA Health Disparities Research Framework provides insights about NIA priority populations, multilevel factors for analysis, and the integrates the life course theory. Applicants are strongly encouraged to use the NIA Health Disparities Research Framework to a) better delineate causal pathways for an intervention, b) broaden the scope of proposed adaptable intervention targets (by reviewing difference cells among the four key domains which provide examples of level of analysis a research team might consider (e.g., individual level, community level, structural level, and c) to potentially identify team members who possess relevant expertise to achieve the intervention’s proposed goals and objectives.

For clinical trial proposals, implementation strategies studied should be limited to the studies of strategies that have evidence of efficacy, as well as evidence that the intervention can be delivered in the community with fidelity. NIA is especially interested in receiving applications that fall within Stage V of the NIH Stage Model for Behavioral Intervention Development that focus on the mechanisms that promote the successful implementation of interventions, consistent with the NIH Science of Behavior Change emphasis on mechanisms of change.

Information about the NIH Stage Model and behavioral intervention development can be found at:https://www.nia.nih.gov/research/dbsr/stage-model-behavioral-intervention-development.

Information regarding NIH’s Science of Behavior Change (SOBC) program can be found at: https://commonfund.nih.gov/behaviorchange.

Specific areas of interest include, but are not limited to:

  • NCD prevention in vulnerable aging and older adults across the life course: implementation research focused on interventions that address common age-related disease risk factors, reduce health risk and/or enhance positive health and lifestyle behaviors, and develop/test implementation strategies to support the uptake, integration and scale up of these interventions. Studies should also examine how and why these interventions work.
  • Studies that test the effectiveness of implementation strategies of interventions to reduce health disparities related to aging and age-related neurological disorders (including AD/ADRD) among minoritized or vulnerable populations (e.g., indigenous populations, rural) in LMICs.
  • Studies to design, develop, and test informed strategies to improve uptake and integration of evidence‐based interventions that mitigate risk for advanced aging and age-related neurological disorders (AD/ADRD).
  • Implementation studies that explore strategies to support the integration of technology, tools, or techniques into epidemiologic or population-based research for data collection and analysis.
  • Studies of implementation strategies for interventions that influence neuropsychological, behavioral and social factors related to life course aging and health, particularly to Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). These may include interventions such as:
    • Healthy lifestyle behaviors such as diet, exercise, sleep, cognitive training, stress and medication management, and adherences to these behaviors.
    • Institutional policy or health system interventions from different contexts employed in new contexts.

Applicants should make the case that these interventions have shown efficacy and can be scaled up.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

The Eunice Kennedy ShriverNational Institute of Child Health and Human Development encourages implementation research applications relevant to the NICHD mission focusing on critical periods throughout the life course. These areas include (but not limited to): normal and abnormal human development, contraception, fertilization, pregnancy, childbirth, prenatal/postnatal development, childhood development through adolescence, intellectual and developmental disabilities, and rehabilitation medicine.

NICHD is interested in evidence based LMIC and AI/AN Tribal Nation population applications relevant to the institute’s mission. Specifically, implementation research studies that address long-term health outcomes and chronic conditions of at-risk mothers and children, interventions that improve pre-pregnancy health, prematurity, malnutrition, childhood stunting, disease, and developmental delays.

For more information about NICHD research priorities visit:

National Institute on Drug Abuse (NIDA)

The National Institute on Drug Abuse is committed to advancing research to address substance use and related disparities among LMIC and AI/AN Tribal Nation populations. NIDA is interested in receiving applications for this FOA that address common NCD risk factors for substance use and that meet the criteria established in this FOA.

National Institute of Environmental Health Sciences (NIEHS)

The mission of the National Institute of Environmental Health Sciences is to discover how the environment affects people in order to promote healthier lives. Its vision is to provide global leadership for innovative research that improves public health by preventing disease and disability. Our environment, including exposures in the physical, built, and social environments, can negatively affect the health of individuals and communities. These environmental exposures disproportionately impact LMICs and AI/AN Tribal Nation populations in the United States. Given the interconnectedness of the environment with individual- and structural-level social determinants of health, ensuring equitable implementation of interventions that prevent or mitigate these environmental exposures and reduce the risk of NCDs is urgently needed.

NIEHS is interested in applications that are within scope of our 2018-2023 Strategic Plan and focus on the implementation of interventions that address environmental NCD risk factors (e.g., air pollution, disaster risks attributed to climate change, etc.) in one or more critical life stages. Specific areas of interest to NIEHS include, but are not limited to:

  • Implementation of interventions to prevent or mitigate environmental exposures in childhood that lead to NCDs (e.g., asthma)
  • Implementation of interventions focused on reducing primary and/or secondary exposures to pesticides and other chemicals in rural and agricultural settings that lead to NCDs in one or more critical life stages
  • Implementation of interventions that focus on mitigating or reducing combined environmental exposures that lead to NCDs in one or more critical life stages
  • Implementation of interventions to reduce environmental NCD risks that consider individual and structural level social determinants of health
  • Implementation of interventions to prevent or mitigate environmental exposures in children, adolescents, young and older adults that are attributed to climate change

National Institute of Mental Health (NIMH)

The National Institute of Mental Health encourages studies across the research spectrum, from basic through translational science to intervention development and efficacy, effectiveness, and implementation research. Mental disorders may be defined according to existing diagnostic criteria or along dimensions of neurobehavioral functioning according to the NIMH Research Domain Criteria (RDoC) framework. If existing diagnostic criteria are to be used, investigators should include plans for addressing heterogeneity within the diagnostic category or categories.

All applications that propose clinical trials to develop or test preventive, therapeutic, or services interventions, including studies that test dissemination and implementation strategies, are encouraged to follow the NIMH’s experimental therapeutics approach to intervention development and testing (see NIMH Clinical Trials FOAs). It is recommended that investigators contact NIMH Scientific/Research staff well in advance of submitting applications to discuss the match to NIMH priorities.

National Institute on Minority Health and Health Disparities (NIMHD)

The National Institute on Minority Health and Health Disparities is specifically interested in innovative, adaptable and real-life multi-level interventions (refer to the NIMHD Research Framework) addressing health/healthcare disparities among indigenous populations of the Americas, and in countries from which there is a significant representation in the U.S. population (e.g., Mexico, Central and South America, and some countries in the Caribbean, sub-Saharan Africa, and some countries in Asia and the Pacific). Also, multi-sectoral interventions are of interest. We encourage research teams to incorporate measurements and assessments of social determinants of health and other common data elements as described in the PhenX Toolkit.

National Institute of Neurological Disorders and Stroke (NINDS)

The National Institute of Neurological Disorders and Stroke encourages impactful applications that seek to equitably address common NCD risk factors through evidence-based interventions for high priority neurological health concerns in LMICs, and AI/AN Tribal Nation populations in the U. S., by aiding in the prevention, diagnosis, or treatment of the disorder. Collaborations that propose cost-effective and scalable approaches, with attention to stakeholder engagement, and strengthening of the regional research capacity for neurological care are encouraged. Research areas of interest include, but are not limited to, interventions for:

  • Advancing remote patient care and monitoring tools for chronic neurological conditions in rural and/or urban settings
  • Further refinement of point of care diagnostics and screening tools for early and accurate neurological disease detection
  • Enabling greater access to more timely and continuous neurological care through cost reductions or novel technology dissemination strategies
  • Improving the remote transmission and clinical utility of neurological imaging technologies to rural hospitals and clinics
  • Implementing or strengthening eHealth/mHealth data collection, standardization or reporting for neurological patients and research participants
  • Improving stroke risk factor surveillance and statistical modeling at the community and national level

High priority disease areas include stroke and other cerebrovascular diseases, epilepsy, migraine, nervous system infections, Parkinson's disease and other neurodegenerative disorders, brain trauma, neurodevelopmental disorders, neuromuscular disorders, and the neurological consequences of HIV/AIDS and Adverse Childhood Experiences (ACEs) (NINDS Disorder Index http://www.ninds.nih.gov/disorders/disorder_index.htm). Projects that build upon previously funded NINDS activities in the Chronic, Noncommunicable Diseases and Disorders Research Training (NCD-Lifespan), Human Heredity and Health in Africa (H3Africa), and the Global Brain Disorders program are also encouraged.

NINDS may decline funding of any application that includes human subjects for programmatic or administrative reasons. Applicants considering projects involving human subjects research are strongly encouraged to contact NINDS Scientific/Research staff early in the process of preparing a submission. Applicants interested in clinical trials for neurological disorders within the NINDS mission, may also refer to NINDS clinical trial-specific funding announcements. See: https://www.ninds.nih.gov/Current-Research/Research-Funded-NINDS/Clinical-Research

NINDS encourages the reuse of Common Data Elements/Data Standards whenever appropriate. Please see: NINDS Common Data Elementshttps://www.commondataelements.ninds.nih.gov/

Modified to Read (changes shown inbold italics):

NOT-TW-21-008- Notice of Intent to Publish a Funding Opportunity Announcement for Implementation Research for Chronic Disease Prevention Across the Lifespan (R01 Clinical Trial Optional)

NOT-HL-22-035 Notice of NHLBI Participation in PAR-22-132 "Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low- and Middle-Income Countries and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional"

Issued by

Fogarty International Center (FIC)

National Eye Institute (NEI)

National Institute on Aging (NIA)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of Mental Health (NIMH)

National Institute of Neurological Disorders and Stroke (NINDS)

National Institute on Minority Health and Health Disparities (NIMHD)

National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

National Heart, Lung, and Blood Institute (NHLBI)

Assistance Living Number(s)

93.989, 93.399, 93.113, 93.866, 93.865, 93.867, 93.279, 93.307, 93.853, 93.242, 93.837, 93.838, 93.839, 93.840, 93.233, 93.837, 93.838, 93.839, 93.840, 93.233

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

NIH IC-Specific Priorities Potential applicants are strongly encouraged to contact NIH IC program staff (listed below) early in the application process to discuss the alignment of their technical proposal with the goals of this FOA, the NIH IC, and the GACD program. NIH IC-specific priorities include the following:

Fogarty International Center (FIC)

NOTE: While theFogarty International Centermanages this program on behalf of NIH, FIC does not accept applications for this funding opportunity. Applications may only be submitted to partner ICs for funding consideration.

National Eye Institute (NEI)

The National Eye Institute supports basic and clinical research into diseases and disorders of the visual system and the special needs of people with impaired vision or who are blind. NEI is particularly interested in research of improved methods for delivering vision care and rehabilitation in underserved populations including people in urban and rural settings, especially those in AI/AN Tribal Nation populations in the United States. Research topics may include but are not limited to telemedicine, screening and automated diagnosis, medication adherence, quality of life, and rehabilitation strategies for those with vision loss.

NEI would only support clinical trial applications for this FOA that fulfill the NIH requirements for either a mechanistic or minimal risk trial. A mechanistic trial is designed to understand a biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention. A minimal risk trial is one in which the probability and magnitude of harm or discomfort anticipated in the research are not greater in and of themselves than those ordinarily encountered in daily life or during the performance of routine physical or psychological examinations or tests.

National Institute on Aging (NIA)

The National Institute on Aging mission is to support and conduct genetic, biological, clinical, behavioral, social, and economic research on aging; foster the development of research and clinician scientists in aging; provide research resources to facilitate innovative aging research; and disseminate information about aging and advances in research to the public, health care professionals, and the scientific community, among a variety of audiences.

NIA’s interest in this program is to support research to identify and understand barriers to the adoption, integration, scale-up, and sustainability of health interventions related to evidence-based practices to encourage healthy lifestyle behaviors related to life course aging and health, including Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), in LMICs and AI/AN Tribal Nation populations in the United States.

The NIA Health Disparities Research Framework provides insights about NIA priority populations, multilevel factors for analysis, and the integrates the life course theory. Applicants are strongly encouraged to use the NIA Health Disparities Research Framework to a) better delineate causal pathways for an intervention, b) broaden the scope of proposed adaptable intervention targets (by reviewing difference cells among the four key domains which provide examples of level of analysis a research team might consider (e.g., individual level, community level, structural level, and c) to potentially identify team members who possess relevant expertise to achieve the intervention’s proposed goals and objectives.

For clinical trial proposals, implementation strategies studied should be limited to the studies of strategies that have evidence of efficacy, as well as evidence that the intervention can be delivered in the community with fidelity. NIA is especially interested in receiving applications that fall within Stage V of the NIH Stage Model for Behavioral Intervention Development that focus on the mechanisms that promote the successful implementation of interventions, consistent with the NIH Science of Behavior Change emphasis on mechanisms of change.

Information about the NIH Stage Model and behavioral intervention development can be found at: https://www.nia.nih.gov/research/dbsr/stage-model-behavioral-intervention-development.

Information regarding NIH’s Science of Behavior Change (SOBC) program can be found at: https://commonfund.nih.gov/behaviorchange.

Specific areas of interest include, but are not limited to:

  • NCD prevention in vulnerable aging and older adults across the life course: implementation research focused on interventions that address common age-related disease risk factors, reduce health risk and/or enhance positive health and lifestyle behaviors, and develop/test implementation strategies to support the uptake, integration and scale up of these interventions. Studies should also examine how and why these interventions work.
  • Studies that test the effectiveness of implementation strategies of interventions to reduce health disparities related to aging and age-related neurological disorders (including AD/ADRD) among minoritized or vulnerable populations (e.g., indigenous populations, rural) in LMICs.
  • Studies to design, develop, and test informed strategies to improve uptake and integration of evidence‐based interventions that mitigate risk for advanced aging and age-related neurological disorders (AD/ADRD).
  • Implementation studies that explore strategies to support the integration of technology, tools, or techniques into epidemiologic or population-based research for data collection and analysis.
  • Studies of implementation strategies for interventions that influence neuropsychological, behavioral and social factors related to life course aging and health, particularly to Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). These may include interventions such as:
    • Healthy lifestyle behaviors such as diet, exercise, sleep, cognitive training, stress and medication management, and adherences to these behaviors.
    • Institutional policy or health system interventions from different contexts employed in new contexts.

Applicants should make the case that these interventions have shown efficacy and can be scaled up.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

The Eunice Kennedy Shriver National Institute of Child Health and Human Development encourages implementation research applications relevant to the NICHD mission focusing on critical periods throughout the life course. These areas include (but not limited to): normal and abnormal human development, contraception, fertilization, pregnancy, childbirth, prenatal/postnatal development, childhood development through adolescence, intellectual and developmental disabilities, and rehabilitation medicine.

NICHD is interested in evidence based LMIC and AI/AN Tribal Nation population applications relevant to the institute’s mission. Specifically, implementation research studies that address long-term health outcomes and chronic conditions of at-risk mothers and children, interventions that improve pre-pregnancy health, prematurity, malnutrition, childhood stunting, disease, and developmental delays.

For more information about NICHD research priorities visit:

National Institute on Drug Abuse (NIDA)

The National Institute on Drug Abuse is committed to advancing research to address substance use and related disparities among LMIC and AI/AN Tribal Nation populations. NIDA is interested in receiving applications for this FOA that address common NCD risk factors for substance use and that meet the criteria established in this FOA.

National Institute of Environmental Health Sciences (NIEHS)

The mission of the National Institute of Environmental Health Sciences is to discover how the environment affects people in order to promote healthier lives. Its vision is to provide global leadership for innovative research that improves public health by preventing disease and disability. Our environment, including exposures in the physical, built, and social environments, can negatively affect the health of individuals and communities. These environmental exposures disproportionately impact LMICs and AI/AN Tribal Nation populations in the United States. Given the interconnectedness of the environment with individual- and structural-level social determinants of health, ensuring equitable implementation of interventions that prevent or mitigate these environmental exposures and reduce the risk of NCDs is urgently needed.

NIEHS is interested in applications that are within scope of our 2018-2023 Strategic Plan and focus on the implementation of interventions that address environmental NCD risk factors (e.g., air pollution, disaster risks attributed to climate change, etc.) in one or more critical life stages. Specific areas of interest to NIEHS include, but are not limited to:

  • Implementation of interventions to prevent or mitigate environmental exposures in childhood that lead to NCDs (e.g., asthma)
  • Implementation of interventions focused on reducing primary and/or secondary exposures to pesticides and other chemicals in rural and agricultural settings that lead to NCDs in one or more critical life stages
  • Implementation of interventions that focus on mitigating or reducing combined environmental exposures that lead to NCDs in one or more critical life stages
  • Implementation of interventions to reduce environmental NCD risks that consider individual and structural level social determinants of health
  • Implementation of interventions to prevent or mitigate environmental exposures in children, adolescents, young and older adults that are attributed to climate change

National Institute of Mental Health (NIMH)

The National Institute of Mental Health encourages studies across the research spectrum, from basic through translational science to intervention development and efficacy, effectiveness, and implementation research. Mental disorders may be defined according to existing diagnostic criteria or along dimensions of neurobehavioral functioning according to the NIMH Research Domain Criteria (RDoC) framework. If existing diagnostic criteria are to be used, investigators should include plans for addressing heterogeneity within the diagnostic category or categories.

All applications that propose clinical trials to develop or test preventive, therapeutic, or services interventions, including studies that test dissemination and implementation strategies, are encouraged to follow the NIMH’s experimental therapeutics approach to intervention development and testing (see NIMH Clinical Trials FOAs). It is recommended that investigators contact NIMH Scientific/Research staff well in advance of submitting applications to discuss the match to NIMH priorities.

National Institute on Minority Health and Health Disparities (NIMHD)

The National Institute on Minority Health and Health Disparities is specifically interested in innovative, adaptable and real-life multi-level interventions (refer to the NIMHD Research Framework) addressing health/healthcare disparities among indigenous populations of the Americas, and in countries from which there is a significant representation in the U.S. population (e.g., Mexico, Central and South America, and some countries in the Caribbean, sub-Saharan Africa, and some countries in Asia and the Pacific). Also, multi-sectoral interventions are of interest. We encourage research teams to incorporate measurements and assessments of social determinants of health and other common data elements as described in the PhenX Toolkit.

National Institute of Neurological Disorders and Stroke (NINDS)

The National Institute of Neurological Disorders and Stroke encourages impactful applications that seek to equitably address common NCD risk factors through evidence-based interventions for high priority neurological health concerns in LMICs, and AI/AN Tribal Nation populations in the U. S., by aiding in the prevention, diagnosis, or treatment of the disorder. Collaborations that propose cost-effective and scalable approaches, with attention to stakeholder engagement, and strengthening of the regional research capacity for neurological care are encouraged. Research areas of interest include, but are not limited to, interventions for:

  • Advancing remote patient care and monitoring tools for chronic neurological conditions in rural and/or urban settings
  • Further refinement of point of care diagnostics and screening tools for early and accurate neurological disease detection
  • Enabling greater access to more timely and continuous neurological care through cost reductions or novel technology dissemination strategies
  • Improving the remote transmission and clinical utility of neurological imaging technologies to rural hospitals and clinics
  • Implementing or strengthening eHealth/mHealth data collection, standardization or reporting for neurological patients and research participants
  • Improving stroke risk factor surveillance and statistical modeling at the community and national level

High priority disease areas include stroke and other cerebrovascular diseases, epilepsy, migraine, nervous system infections, Parkinson's disease and other neurodegenerative disorders, brain trauma, neurodevelopmental disorders, neuromuscular disorders, and the neurological consequences of HIV/AIDS and Adverse Childhood Experiences (ACEs) (NINDS Disorder Index http://www.ninds.nih.gov/disorders/disorder_index.htm). Projects that build upon previously funded NINDS activities in the Chronic, Noncommunicable Diseases and Disorders Research Training (NCD-Lifespan), Human Heredity and Health in Africa (H3Africa), and the Global Brain Disorders program are also encouraged.

NINDS may decline funding of any application that includes human subjects for programmatic or administrative reasons. Applicants considering projects involving human subjects research are strongly encouraged to contact NINDS Scientific/Research staff early in the process of preparing a submission. Applicants interested in clinical trials for neurological disorders within the NINDS mission, may also refer to NINDS clinical trial-specific funding announcements. See: https://www.ninds.nih.gov/Current-Research/Research-Funded-NINDS/Clinical-Research

NINDS encourages the reuse of Common Data Elements/Data Standards whenever appropriate. Please see: NINDS Common Data Elements https://www.commondataelements.ninds.nih.gov/

National Heart, Lung, and Blood Institute (NHLBI)

The National Heart, Lung, and Blood Institute encourages innovative implementation research that is within scope of NHLBI’s Strategic Vision, and aligns with in-country national heart, lung, blood, and sleep (HLBS)-related non-communicable disease programs and policies for national population impact.

  • Implementation research to address prevention and control of HLBS diseases targeting multiple levels including: patients and the community; health care providers and alternative providers (e.g., use of midlevel providers such as community health workers, nurses, pharmacists, etc.); and the health care delivery system level within LMICs and American Indian/Alaska Native (AI/AN) Tribal Populations in the U.S. during the implementation of national HLBS disease prevention programs
  • Implementation research to understand the optimal, acceptable, and sustainable strategies for task-shifting to and task-sharing with various health care workers (especially within human resource shortage areas, e.g., rural areas) to deliver national policy for clinical and public health interventions within the national healthcare system
  • Studies that can test the optimal use of nurse case managers in low-resource settings to deliver evidence-based guidelines for prevention, treatment, and control of HLBS diseases across urban, rural, and low resource areas aligned with national non-communicable disease programs
  • Implementation research to improve delivery of national HLBS disease prevention and control policies that identify optimal strategies using mobile health technologies and other informatics-enabled devices (e.g., electronic sliding scales, smartphone apps., etc.) to improve intervention adherence at the level of the patient, provider, and health system
  • Studies that take the recommended World Health Organization “Best buys” interventions at the community level and across all levels, and test optimal, affordable, and sustainable strategies for delivery of national policy recommendations for HLBS prevention and control

These examples can also be tailored to align with country-based World Bank-funded health sector development that aligns with national policies. All examples are assumed to use validated implementation research frameworks and primary population-level implementation research outcomes.

Inquiries

Please direct all inquiries regarding this Notice to:

Makeda Williams, Ph.D., M.P.H.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-451-7594
Email: willimak@mail.nih.gov
 

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