Notice of Intent to Publish a Request for Applications for Next Generation Association Studies (U01)

Notice Number: NOT-HL-10-100

Key Dates
Release Date: October 16, 2009

Issued by
National Heart, Lung, and Blood Institute (NHLBI), (


The National Heart, Lung, and Blood Institute (NHLBI) intends to release a Request for Applications (RFA) to solicit applications for the Next Generation Association Studies (U01) Program.  The overall goal of this initiative is to build upon existing genome-wide association study (GWAS) findings with functional information gained by assessing cellular profiles that are surrogates for disease phenotypes.  Specifically, the purpose of this initiative is twofold, and proposals should include both phases described below.  First, NHLBI proposes a technology development phase which goal is to utilize emerging induced pluripotent stem (iPS) cell generation and differentiation technology at the level of population samples.  The availability of such technology on a production scale will enable the second implementation phase that will apply cellular reprogramming and molecular profiling to population-based samples and will integrate this information with existing genotypic and phenotypic data. The resulting data will allow assessment of how human genetic variation influences the activities of biological networks in cell-based models of disease.  Proposals incorporating both phases to address this goal will require a multidisciplinary approach, consisting of teams including, but not limited to, epidemiologists, clinicians, population geneticists, stem cell and molecular biologists and specialists in bioinformatics.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.  The RFA is expected to be published in early Spring 2010 with an expected receipt date in June 2010.

The RFA will use the U01 grant mechanism.



Interested parties may contact:
Cashell E. Jaquish, Ph.D.
Division of Cardiovascular Sciences
National Heart, Lung, and Blood Institute
National Institutes of Health
6701 Rockledge Drive  MSC 7936
Suite 10018
Bethesda, MD 20892-7936
ph:  301-435-0447
fax: 301-480-1455

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