RELEASE DATE:  March 24, 2004

National Heart, Lung, and Blood Institute (NHLBI) 

This Notice is to extend the scope of research that may be considered under the Request 
for Applications (RFA) Pulmonary Complications of Sickle Cell Disease RFA-HL-04-015

Studies on the respiratory and vascular effects of sleep disordered breathing will 
improve our understanding of the association between sickle cell crises and sleep. 
Applications proposing to integrate clinical and basic scientific research on the role 
of upper airway obstruction and sleep disturbances in acute chest syndrome and other 
pulmonary complications of sickle cell disease will be considered under this RFA.  
Examples of potential research directions under this domain include elucidating the 
role of sleep-related hormonal and autonomic dysfunction leading to vaso-occlusion in 
sickle cell disease; the role of sleep disordered breathing in pulmonary hypertension 
associated with sickle cell disease; the role of intermittent sleep hypoxemia in sickle 
cell pathophysiology including adhesion to pulmonary vascular endothelium, free radical 
generation, and immunobiology; and the potential benefits of treating sleep disturbance 
in reducing sickle cell specific morbidity and mortality.  

Special requirements and additional features of this program can be found in the full 
text of the original RFA announcement.


Direct your questions regarding NHLBI scientific/programmatic interests to:

Henry Chang, M.D.
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute
Rockledge II, Room 10158 (MSC 7950)
Bethesda, MD  20892 - 7950 (20817 for overnight couriers)
Telephone:  (301) 435-0067
FAX: (301) 480-0868

Andrea L. Harabin, Ph.D.
Senior Scientific Advisor, Lung Biology and Disease Program
Division of Lung Diseases
National Heart, Lung, and Blood Institute      
Rockledge II, Room 10108 (MSC 7952)               
Bethesda, MD  20892 - 7952 (20817 for overnight couriers)
Telephone:  (301) 435-0222
FAX: (301) 480-3557

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