NHLBI ADMINISTRATIVE SUPPLEMENTS FOR HUMAN EMBRYONIC STEM CELL RESEARCH

RELEASE DATE:  January 29, 2002

NOTICE:  NOT-HL-02-009

National Heart, Lung, and Blood Institute (NHLBI)
 (http://www.nhlbi.nih.gov/index.htm)

The National Heart, Lung, and Blood Institute (NHLBI) announces the 
availability of administrative supplements to NHLBI grantees to conduct 
research using human embryonic stem (ES) cell lines.  The ES cell line used 
must be listed on the NIH Human Embryonic Stem Cell Registry  
(http://escr.nih.gov; additional guidance may be found at 
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-006.html).  
NHLBI-funded investigators may request an administrative supplement not to 
exceed $50,000 in direct costs (two modules) per year for the purpose of 
conducting research for a one or two year period.  The applicant must have an 
existing NHLBI funded award during the time of the supplement, and therefore 
must have at least a one or two year funding period remaining at the time the 
supplement is awarded.  

Administrative supplements can only be awarded for research that is within the 
scope of an existing, funded grant.  For example, investigators carrying out 
murine ES cell work may elect to request funding to extend their 
investigations to human ES cell lines.  Other investigators carrying out stem 
cell research, developmental studies, or other related studies may also apply. 
In all cases, a careful explanation and justification for the supplement must 
be included.    

Investigators must contact the human ES cell line providers listed on the NIH 
Registry independently and make arrangements to obtain the cell lines, 
including any required material transfer agreements (MTA).  Applicants must 
indicate which human ES cell line or lines will be used.  A letter indicating 
the provider will supply the human ES cell line must be furnished either with 
the application or just prior to the award.  The investigators should also 
demonstrate either prior ability to work with human ES cell lines or outline 
plans for obtaining training to culture human ES cells.  The human ES cell 
line providers, other laboratories with ES cell experience, or laboratory 
training courses on ES cell methods are potential means of obtaining this 
training.  Other means for acquiring human ES cell expertise may be proposed.

NHLBI intends to commit up to $3,000,000 in FY 2002 to fund up to 40 
supplements.  This is a one-time announcement.  However, the NHLBI may re-
release the announcement, depending on the needs of the NHLBI scientific 
community, and the availability of funds.  There will be four receipt dates 
for administrative supplements: March 15, 2002; April 15, 2002; May 15, 2002 
and July 15, 2002.  Up to 10 awards will be made for the first three receipt 
dates with the remainder of the awards to be made after the fourth receipt 
date.  Awards will be made depending on the receipt of a sufficient number of 
qualified applications and the availability of funds.  Awards will be made 
within 6 to 8 weeks after the receipt dates.

To apply for an administrative supplement, send an original letter 
countersigned by the grantee institution=s authorized business official 

and one copy to Dr. Thomas, Kelley, or Berberich at the addresses below.  The 
letter (5 page limit) must include: 1) an abstract of the proposed 
supplemental activity and how it is related to the parent grant; 2) expected 
overall impact of the requested supplement on ongoing research results; 3) the 
NIH code for the human ES cell line(s); 4) a justification of budget request 
and funding period; and 5) current contact information for the principal 
investigator, including mailing and e-mail address.  Although these 
descriptions should be as concise as possible, sufficient detail must be 
provided to allow the NHLBI to determine if the request qualifies as an 
administrative supplement.

NHLBI will consider supplement requests from all eligible applicants.  
Requests will be evaluated according to the following criteria:

o The proposed research falls within the scope of the parent grant and is a 
logical extension of the goals and objectives, but not sufficiently different 
to constitute new research or program expansion.

o The applicant's proposal will provide the resources and expertise necessary 
to design and perform the experiments using human ES cells.

o Documentation and justification of the requested budget.

Supplement requests will be reviewed by a committee of NHLBI program staff.  
The applicant will be notified of the evaluation decision within 4 weeks 
following the submission date.  If not furnished with the application, a 
letter indicating the human ES cell line provider(s) will supply the cell 
line(s) will be required prior to award.  Guidance regarding research 
involving human ES cells is available from the Office for Human Research 
Protections (http://www.hhs.gov/ohrp/references/HESCGuidance.pdf).  Any 
human subjects issues must be addressed prior to award.  Award decisions will 
be based upon the criteria provided above, availability of funds, and NHLBI 
programmatic priorities and balance across heart, lung, and blood disorders. 

Direct inquiries regarding program issues to:

Dr. John W.  Thomas						
Division of Blood Diseases and Resources / NHLBI	
6701 Rockledge Drive / Room 10154 /Mail Stop 7950
Bethesda, MD  20892-7950
Telephone:  (301) 435-0050
E-mail:  ThomasJ@nhlbi.nih.gov
FAX:  (301) 451-5453

Dr. Christine Kelley						
Division of Heart and Vascular Diseases / NHLBI			
6701 Rockledge Drive / Room 9142 / Mail Stop 7940
Bethesda, MD  20892-7940
Telephone:  (301) 435-0513
E-mail:  KelleyC@nhlbi.nih.gov
FAX:  (301) 480-1335

Dr. Mary Ann Berberich 					
Division of Lung Diseases / NHLBI							
6701 Rockledge Drive /Room 10102 / Mail Stop 7952
Bethesda, MD  20892-7952
Telephone:  (301) 435-0222
E-mail:  BerberiM@nhlbi.nih.gov
FAX:  (301) 480 - 3557

Direct inquiries regarding fiscal issues to:

Suzanne White
National Heart, Lung, and Blood Institute
6701 Rockledge Drive / Room 7154 / Mail Stop 7926
Bethesda, MD  20817-7926
Telephone:  (301) 435-0171
FAX:  (301) 480-3310
Email:  WhiteSA@nhlbi.nih.gov

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