MICROARRAY TECHNOLOGY AND APPLICATION IN HEART, LUNG, AND BLOOD RESEARCH
Release Date: August 11, 2000
NOTICE: HL-01-002
National Heart, Lung, and Blood Institute
BACKGROUND
Heart, lung, blood, and sleep disorders are complex human conditions that,
until recently, have been viewed from the perspective of only one or a few
genes operating at a time. With the progress of the Human Genome Project, we
will soon be able to examine all human genes simultaneously and attempt to
relate them to research questions relevant to heart, lung, blood, and sleep
disorders. A key tool in this endeavor will be microarray technology.
PURPOSE
The challenge before the National Heart, Lung, and Blood Institute (NHLBI) is
to determine the most appropriate, effective, and timely strategies to
address the needs, facilitate the opportunities, and minimize the obstacles
in fully developing and applying array technologies to heart, lung, blood and
sleep research Thus, the NHLBI is soliciting input from the scientific
communities that it serves to guide in the development of these strategies.
PROCESS
The NHLBI is requesting that you send us your thoughts, opinions, and
suggestions in each of the key areas described below [each is defined by a
keyword(s)]. Responses may be sent through the online form
(http://www.nhlbi.nih.gov/resources/medres/rfinote.htm), by letter, email, or
fax to the address listed below by September 1, 2000.
MICROARRAYS
You may have encountered significant barriers to gaining access to microarray
technology. The NHLBI would like to hear your comments, views, and opinions
on barriers to access (e.g., technology, resources, or other) and on barriers
to optimal use of microarrays (e.g. lack of expertise, financial limitations,
or other). If you are currently using microarrays in your research, please
describe how you overcame barriers to access in applying microarray
strategies to your research.
NHLBI is currently studying ways in which it can increase the base of
participation in microarrays. Your thoughts are welcome on the best ways to
facilitate access to microarray technology in the heart, lung, blood and
sleep research communities Examples could include a grant supplement program
for microarray implementation in ongoing programs, a resource facility that
would make and distribute custom chips of interest to the NHLBI community, a
program directed toward technology development, a program to support local or
regional chip development and distribution, or an expanded effort as
facilitator to bring together investigators with common interests so as to
share costs.
There is universal agreement that good bioinformatics and information
resources are essential tools for the optimal use of high-throughput gene
analysis methods such as microarrays. Your suggestions for the best ways for
NHLBI to help develop and disseminate these tools are welcome.
The NHLBI is interested in your assessment of the overall needs and research
opportunities that microarray access and application afford that cannot be
addressed by other means. Any specific suggestions, and general estimates of
associated costs, for how NHLBI can meet these needs would be valuable.
We would appreciate any additional thoughts or comments that you think would
be useful.
Thank you for your help.
We look forward to your input and please share this document with your
colleagues.
To respond, please send a letter, fax or email to the following address or
link to the online form in the What’s New section on the NHLBI Home Page.
Ms. Tawanna Meadows
Two Rockledge Centre
6701 Rockledge Drive
Room 9163, MSC 7940,
Bethesda, Maryland 20892-7940
FAX (301) 480-1335
Phone (301) 435-1802
Email: array@nhlbi.nih.gov
Barriers
Overcoming Barriers
Facilitating Access
Bioinformatics and Information Resources
Overall Needs and Research Opportunities
Suggestions
Additional Thoughts or Comments
Weekly TOC for this Announcement
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