Release Date:  November 18, 1999 (see replacement NOT-HL-03-006)

NOTICE:  HL-00-002

National Heart, Lung, and Blood Institute

This notice supplements the NIH Mentored Clinical Scientist Development Award 
Program Announcement (PA-00-003) described in the  NIH Guide for Grants and 
Contracts, 10/8/99, with additional information specific to the NHLBI award.  
All information in the NIH Program Announcement pertains to the NHLBI award.  
Prospective applicants should use both the NIH Guide and the supplemental 
NHLBI information listed below in completing their applications.  Consultation 
with program staff listed under AINQUIRIES@ is recommended before submitting 
an application.

The K08 Award provides research development opportunities for clinical 
research scientists with varying levels of research experience who are 
committed to developing into independent investigators skilled in the advanced 
methods and experimental approaches needed to solve problems in 
cardiovascular, pulmonary, blood diseases and transfusion medicine, and sleep 
disorders.  The K08 Award is intended to provide flexibility in developing a 
program suited to the experience and capabilities of the candidate.

Specific information for NHLBI applicants:

Eligibility:  Candidates must have a health professional doctoral degree, such 
as the M.D., D.O., D.V.M., or equivalent degree, and a professional license to 
practice in the United States.  Documentation of active licensure should be 
included in the application.  Applications may be accepted from those who hold 
a Ph.D. degree in addition to the professional degree provided the Ph.D. 
degree was either: 1) obtained in an unrelated field; 2) obtained prior to the 
M.D. degree; or 3) obtained concurrent with the professional degree and an 
intervening period of clinical training or other non-research activities 
occurred since completion of the concurrent degree. 

Integration of Research Training with Clinical Training:  The K08 Award can be 
integrated with the requirements for clinical subspeciality training, and 
differing approaches for doing so may be proposed.  A K08 Award plan may 
include an interruption in grant support to allow for continued clinical 
training.  For example, individuals may propose a program encompassing up to a 
12-month hiatus to allow for completion of subspeciality training, followed by 
continuation of the research career development program.  A hiatus of up to 24 
months would be considered only under unusual circumstances with strong and 
compelling justification.  Award support is not provided during periods of 
interruption; periods of leave do not reduce the total number of months of 

Concurrent Competing Applications:  K08 applicants may not hold any other 
Federal or non-Federal equivalent salary award, such as the American Heart 
Association Scientist Development Grant.

Subsequent Applications for NIH Research Support:  K08 Award recipients who 
apply for other research grant support are reminded to include salary and all 
other research needs in the research grant application for the period 
following completion of the K08 Award.  Alternatively, recipients of research 
grant awards may terminate the K08 Award prior to the start of the research 

Other Provisions:

The NHLBI recommends, but no longer requires, an advisory committee composed 
of the candidate=s mentor(s) and at least two other senior faculty members.  

Allowable Costs:

a.  Salary.  NHLBI will provide salary not exceeding $75,000 per year plus 
commensurate fringe benefits for essentially full-time participation, i.e., at 
least 75% effort devoted to the research program.  The salary requested must 
be consistent both with the established salary structure at the institution 
and with salaries actually provided by the institution from its own funds to 
other staff members of equivalent qualifications, rank, and responsibilities 
in the department concerned.  

b.  Research  Development Support.  NHLBI will provide a maximum of $25,000 
per year to awards made in FY 99 or later.  

Receipt Dates:  Both new AND amended K08 applications submitted to NHLBI have 
the same annual receipt dates:  February 1, June 1, and October 1.  


K08 applicants must describe plans to receive instruction in the responsible 
conduct of research.  These plans must detail the proposed subject matter, 
format, frequency, and duration of instruction.  No award will be made if an 
application lacks this component.  

All career award applicants must provide information on their citizenship 
status by utilizing the special table of contents for career award 
applications (see below under Application Procedures).  

Application Procedures:  Applicants are reminded that there are special 
instructions for preparing individual career award applications in the PHS 
398, beginning on page IV-1.  Do not use the instructions for regular research 
grants found in the PHS 398. 

NHLBI asks that mentor(s) include in the application a list of their current 
and past research trainees (not more than the last 10 years) with information 
on their current positions.

The original and 4 copies of the completed application should be sent to:
Center for Scientific Review
National Institutes of Health
Suite 1040
6701 Rockledge Drive, MSC 7710
Bethesda MD 20892-7710
Bethesda, MD 20817 (for courier service)
Telephone: (301) 435-0715

and one copy to:

C. James Scheirer, Ph.D.
Chief, Review Branch
Division of Extramural Affairs, NHLBI
6701 Rockledge Drive, MSC 7924
Bethesda, MD 20892-7924
Bethesda, MD 20817 (for courier service)
Telephone: (301) 435-0266
FAX:          (301) 480-3541
E-mail: james_scheirer@nih.gov


Please contact the following NHLBI staff member if you have questions 
regarding programmatic issues:

Lorraine M. Silsbee, M.H.S.
Division of Epidemiology and Clinical Applications
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, MSC 7934
Bethesda, MD 20892-7934
Telephone:  (301) 435-0709
FAX:  (301) 480-1667
E-mail:  Silsbeel@nih.gov

Direct inquiries regarding fiscal matters to:

Grants Operations Branch
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, MSC 7926
Bethesda, MD 20892-7926
Telephone: (301) 435-0144

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