NOTICE of NHGRI Participation in PA-14-046 “Mentored Clinical Scientist Research Career Development Award (Parent K08)”

Notice Number: NOT-HG-14-019

Key Dates
Release Date: February 3, 2014

Related Announcements
PA-14-046
NOT-HG-14-018

Issued by
National Human Genome Research Institute (NHGRI)

Purpose

The National Human Genome Research Institute (NHGRI) announces its participation in the Mentored Clinical Scientist Research Career Development Award (Parent K08) (PA-14-046), with a focus on genomic medicine.

In February 2011, NHGRI published:  Charting a course for genomic medicine from base pairs to bedside.  The paper was an all-encompassing document for the field of genomics.  Based on this document, NHGRI has redefined the goals for its research and training and career development programs.  

Through a series of advisory panels and workshops (2012 Report2012 Video PresentationApril 2013 ReportSeptember 2013 Report and Video Presentation), NHGRI has identified three main goals for its training and career development programs:

1. Expand the number of individuals with a knowledge base in genomic medicine;

2. Continue to support individual development of investigators working in the foundational sciences, with emphasis on acquiring strong quantitative skills; and

3. Develop leaders of research in genomic medicine and genome sciences.

Other overarching principles, recurring themes and recommendations are detailed in the reports.  The reports specifically recommended that NHGRI’s career development program include a new career development award focused in genomic medicine.

Objectives of the Mentored Clinical Scientist Research Career Development Award in Genomic Medicine
The program objective is to develop research leaders in genomic medicine by providing a mentored research experience to those who plan to transition their research efforts to genomic medicine.  The program is open to those with MD degrees or their equivalents and those with a Ph.D. who are currently working in a clinical area or who wish to transition their research efforts into genomic medicine.

The mentoring program should ensure that the awardee will develop a knowledge base and skill sets in an additional scientific area that may include:  1) clinical medicine and the application of genomics; 2) quantitative sciences (includes mathematics, statistics); and 3) informatics (bioinformatics and computational biology). The focus must be on developing a comprehensive research training experience in genomics.  The application should provide a detailed description of: (1) the didactic plan and (2) the research plan.

The key elements of a responsive application might include:

  • A statement addressing the general approach the applicant is trying to develop or the general problem to be solved, and how that could be applicable across diseases.  Research that is not generalizable to many different diseases will not be considered responsive.”  (A defined curriculum in the scientific area to be cross-trained and a plan to take the appropriate courses and laboratory rotations, or to undertake the clinical experiences needed to complement the applicant’s existing expertise);
  •  A description of the applicant’s prior training and how it relates to the immediate objectives and long-term career goals;
  • A description of the roles of the dual mentors and how the mentoring will be accomplished to encompass the complementary areas of expertise;
  • A training plan that demonstrates a logical progression from prior research and training experiences to the development of a genomic medicine researcher;
  • An environment rich in a diverse menu of genomic research, the generation of large datasets and the clinical interpretation of these data;
  • Access to critical resources, such as health information datasets, clinical datasets, patients, etc.
  • Career development and professional guidance, such as skills for writing manuscripts and grant applications.
  • A team science approach to problem solving. 

Budget
The salary is capped at Executive Level 1 (FY2014 published amount).  The salary must be consistent both with the established salary structure at the institution and with salaries actually provided by the institution from its own funds to other staff members of equivalent qualifications, rank, and responsibilities in the department concerned.  Up to $40,000 may be requested for research support.   Candidates may request a minimum of nine (9) calendar months or 75% of full-time professional effort to conduct health-related research. The remaining effort may be devoted to other research pursuits and activities consistent with the objectives of the award. Awardees and their mentors are required to attend one annual networking meeting in the DC Metropolitan Area.  Travel for the mentor as well as the candidate may be requested.

Special Note
To make sure that your application is responsive to this FOA, prior consultation with NHGRI staff is strongly encouraged.

Inquiries

Please direct all inquiries to:

Scientific/Research Contacts:
Heather A. Junkins, M.S.
Training Program Director
Email: junkinsh@mail.nih.gov

Tina Gatlin, Ph.D.
Training Program Director
Email: christine.gatlin@nih.gov

Financial/Grants Management Contact:
Susan Toy
Senior Grants Management Specialist
Email: toys@mail.nih.gov

National Human Genome Research Institute/NIH
Telephone:  301-496-7531
Website: http://www.genome.gov

 

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