Notice of Intent to Publish a Funding Opportunity Announcement for Genomic Medicine Pilot Demonstration Project (U01)

Notice Number: NOT-HG-12-011

Key Dates
Release Date: March 7, 2012

Issued by
National Human Genome Research Institute (NHGRI)


The National Human Genome Research Institute (NHGRI) intends to publish a Funding Opportunity Announcement (FOA) to solicit for a consortium of collaborative genomic medicine pilot demonstration projects, designed to demonstrate the feasibility of, and develop methods for, incorporating an individual patient’s genomic findings into their clinical care.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Summer, 2012, with an expected receipt date in Fall, 2012.

This FOA will utilize the U01 activity code.  Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of assessing the feasibility of, and developing methods for, incorporating an individual patient’s genomic findings into their clinical care, to begin to consider applying for this new FOA.

The goals of this initiative are to expand existing genomic medicine efforts, and develop new collaborative projects and methods, in diverse settings and populations; contribute to the evidence base regarding outcomes of incorporating genomic information into clinical care; and define and disseminate the processes of genomic medicine implementation, diffusion, and sustainability in diverse clinical settings. 

For the purposes of this initiative,is to incorporate an individual patient's genomic information (as reflected by their own genotypic, sequencing, family history, etc., data) into decision-making about their clinical care.

Among the areas of research encouraged in this initiative are screening for highly penetrant germline mutations to identify genetically at-risk individuals, integrating patient-reported family history information into the electronic medical record (EMR), and providing appropriate clinical decision support (CDS) for these efforts.  Research designed to apply pharmacogenomic information in drug selection and dosing, and to use an individual patient's whole exome or genome sequence data for diagnosis or treatment, is also encouraged to the extent that proposed studies do not overlap with the current substantial NHGRI and NIH investments in these areas.  It should be noted the areas listed above are only examples; innovative approaches for demonstrating the feasibility, and assessing the effects, of incorporating a patient's genomic findings in their clinical care are encouraged within the constraints of programmatic balance.  



Please direct all inquiries to:

Ebony Bookman, PhD
Office of Population Genomics
National Human Genome Research Institute
530 Davis Dr., MSC K3-02
Durham, NC 27713
Telephone: 919-541-0367

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.