Notice Number: NOT-HD-10-006
Release Date: February 18, 2010
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (http://www.nichd.nih.gov)
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on developmental mechanisms of human structural birth defects. The proposed FOA will solicit innovative, multidisciplinary, interactive, and synergistic program project (P01) applications that integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of congenital structural human malformations. To contain costs, each P01 will consist of only three component projects and associated cores. At least one project must use basic research in an animal model system and at least one project must be clinical or translational in nature. The component projects must share a common central theme, focus, or objective on a specific developmental structural malformation or class of anomalies that is analogous or homologous in both animal models and humans.
This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published as a Request for Applications (RFA) in June 2010 with an expected receipt date in October 2010. This FOA will utilize the program project (P01) application. Details of the planned FOA are provided below.
Research Initiative Details
This Notice encourages investigators with expertise and insights into congenital structural human malformations to begin to consider applying for this new FOA. Collaborative investigations combining expertise in basic animal model research as well as clinical research are required for this funding opportunity. Investigators funded through this initiative will become part of NICHD’s Birth Defects Working Group started under the NICHD’s Birth Defects Initiative in 2000. The Working Group is comprised of investigators funded through a series of solicitations over the years and meets annually to share research results and expertise and to foster collaborations.
Among the areas of research encouraged in this initiative are developmental defects of generalized body patterning and localized dysmorphic anomalies in a variety of organ systems such as the skeletal, nervous, and visceral systems that lead to clinically significant and major congenital structural malformations. In particular, studies that focus on modifier genes and the role of quantitative aspects of development, such as gene dosage or copy number variation, are being solicited. While applications focusing on developmental disorders that result in intellectual disabilities and related neurobehavioral disabilities are of interest to the NICHD, they are outside the scope of this FOA.
APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.
Lorette C. Javois, Ph.D.
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Center for Developmental Biology and Perinatal Medicine (CDBPM)
Developmental Biology, Genetics and Teratology Branch (DBGT)
6100 Executive Boulevard, Room 4B01, MSC 7510
Bethesda, MD 20892-7510
Rockville, MD 20852 for courier/non-USPS service
Phone: (301) 496-5541
Fax: (301) 480-0303
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
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