SERVICES IN SUPPORT OF THE CONTRACEPTION AND REPRODUCTIVE HEALTH BRANCH, 
CENTER FOR POPULATION RESEARCH, NICHD

Release Date:  May 31, 2000

NOTICE:  HD-00-007

SOURCES SOUGHT:  NICHD-SS-00-003

National Institute of Child Health and Human Development

The Contraception and Reproductive Health Branch, Center for Population 
Research, National Institute of Child Health and Human Development, is seeking 
to identify organizations with experience and capabilities in steroid 
synthesis.  Synthesis of one to three kg and 10 to 15 kg batch sizes of 7-
methylestrone is desired, following the literature [Wieland, P. and Anner, G., 
Helv. Chim. Acta, 50, 289 - 296 (1967)], including patent procedures (U.S. 
Patent 3,318,929,  May 9, 1967 to CIBA Corp.).  It is anticipated that 
optimization is required for the best overall yield for the literature or 
patent procedures.  The final product must have greater than 98 percent 
purity.  A stereoselective total synthesis of racemic 7-methylestrone should 
not be considered for this purpose.  Organizations should have in-house 
analytical capabilities for the determination of chemical and optical purity, 
including the presence of impurities as well as solvents.  

Organizations interested in performing such work should submit a summary of 
their capabilities and experience with similar projects, including personnel 
and equipment that could be assigned to the project.  This notice is NOT a 
request for proposals (RFP).  A determination to issue an RFP will be based, 
in part, on responses received to this notice.  Future information on this 
topic may be found at the NICHD Contracts Management website: 
http://www.nichd.nih.gov/oam/cmb/cmb.htm. 

All organizations with the capabilities to meet this need should submit a 
brief (less than 10 pages) Capability Statement by COB, June 15, 2000.  Three 
copies should be sent to: 

Mr. Charles W. Grewe
Contracting Officer
Contracts Management Branch, OAM, NICHD
6100 Executive Blvd., Suite 7A07, MSC 7510
Bethesda, Maryland 20892-7510
Telephone:  (301) 496-4611 
Fax:  (301) 402-3676
E-Mail:  nichdcmb@mail.nih.gov 

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