NIGMS Administrative Supplements for Collaborative Science

Notice Number: NOT-GM-08-130

Update: The following update relating to this announcement has been issued:

Key Dates
Release Date:  September 8, 2008

Receipt Dates: December 15, 2008; March 15, 2009; June 15, 2009; December 15, 2009 .

Issued by
National Institute of General Medical Sciences (NIGMS) (


The National Institute of General Medical Sciences (NIGMS) announces the availability of funds for administrative supplements to NIGMS-funded research projects. These funds are intended to enhance ongoing research by stimulating and supporting new multidisciplinary collaborations among NIGMS grantees and other members of the scientific community.  Collaborations that bring together ideas and approaches from disparate scientific disciplines are particularly encouraged, as are those involving individuals from groups that are currently underrepresented in the biomedical sciences. These collaborative activities must be within the scope of the approved aims of the parent award, and are expected to provide novel scientific approaches to the research plan for the NIGMS grantee and collaborators.


Complex biological problems often require integrative and multidisciplinary approaches for their solution. However, individual laboratories may lack the necessary breadth of expertise and resources to achieve this goal. The collaboration of investigators with different intellectual and technical approaches may promote the novel insights required to achieve significant research advances. Large and medium scale collaborative efforts can be supported by Program Projects (P01) or by single or multiple PI Research (R01) grants. Smaller scale collaborations also can lead to significant advances, particularly when they take advantage of new information and new or improved approaches. However, fiscal constraints may limit the ability of researchers to initiate new collaborative efforts that would advance a line of research during the course of a project.  Accordingly, NIGMS has developed the Administrative Supplements for Collaborative Science (SCS) Program to enable NIGMS-funded researchers to form new collaborations that were not anticipated at the time of submission, review and funding of the NIGMS parent grant.

The NIH and NIGMS recognize a compelling need to promote diversity in the biomedical sciences workforce. PIs are encouraged to consider collaborations with individuals underrepresented in the biomedical sciences, such as those from underrepresented racial and ethnic groups and individuals with disabilities.


The current announcement is for supplements to NIGMS-supported R01, R37, and SC1 research projects. To be eligible, the parent grant must be active, and the existing grant must have at least eighteen months remaining at the time that the supplement is awarded. The proposed supplement MUST be within the general scope of the peer-reviewed activities and aims approved within the Parent grant. Existing collaborative arrangements are not eligible for this supplement. The leader of each collaborating group should hold the equivalent of an independent faculty appointment in academia or group leader in industry, and have active peer-reviewed grant support from NIH, other funding agencies, or foundations. Exceptions may be granted if the leader is from industry, a foreign institution or an allied field not traditionally supported by peer-reviewed grants.

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, submit a request in writing to the Institute/Center, not to the Division of Receipt and Referral, Center for Scientific Review. The request must be signed by the authorized Business Official and describe the need for additional funding and the categorical costs.

Requests under this notice should use the PHS 398 forms (rev. 11/2007; available at and include the following elements in the request packet. Font size restrictions apply as designated within the PHS398 (rev. 4/2006) instructions.)

1) Cover Letter - Citing this Notice (NOT-GM-08-130), a request for an Administrative Supplement, and the following information:

The cover letter must be signed by the authorized organizational representative/institutional official.

2) PHS 398 Form Page 1 (Face page) MS Word  PDF

The title of the project (Box 1) should be the title of the parent award.
This Notice (number and title, “NIGMS Administrative Supplements for Collaborative Science) should be cited in Box 2, and the “yes” box should be checked.
The Principal Investigator (PI) must be the same as the PI on the parent award. If the parent award is a multiple PI, list the Contact PI as the PI for the supplement request. Administrative supplements cannot be used to make changes to a multiple PI team or to convert a grant from single PI to multiple PI.
The remaining items on the face page should be filled out in accordance with the PHS 398 application instructions.

3) PHS 398 Form page 2  MS Word  PDF
Note: The project “summary” is that of the administrative supplement, not the parent grant.

4) A brief proposal describing the project, including:

a) Scope of the effort and the anticipated contribution of the requested collaboration (not to exceed six pages). Provide a brief description of the scope of the overall project on which the supplemental request is based. This section (five page maximum) should include a description of the supplement's specific aims, including research design and methods, data analysis, and a description of each collaborating group’s contributions.  Describe the relationship of the supplement request to the parent grant, how it will enhance the approved aims of the parent grant, and why the work cannot be accomplished as part of the parent grant (1 page). 

b) Budget for the supplement with a justification that details the items requested, including Facilities and Administrative costs.  See Budget and Funding Information below.

c) Biographical Sketch for all new key personnel (those who are additions on the supplemental project) MS Word  PDF

d) Human Subjects/ Vertebrate Animal documentation (if applicable). Include a current Human Subjects/IRB or Vertebrate Animals/IACUC approval letter, if available. Otherwise, this will be required at the time of funding. All appropriate IRB and IACUC approvals must be in place prior to a supplement award being made. 

Any differences in the involvement or use of human subjects or specimens between the administrative supplement activity and the parent grant should be noted.  When appropriate, details should be provided on the protection of human subjects and inclusion of women, children, and minorities.  Additional guidance on Human Subjects Research and Vertebrate Animals is provided under Part II of the PHS 398 instructions (  

e) PHS 398 Checklist Form MS Word  PDF

Selection Factors

Administrative supplement requests will be reviewed administratively by NIGMS Program and Grants Management Staff.  Selection factors will include the following:

Proposals that constitute an expansion of the specific aims of the parent grants must be submitted as a Revision (previously termed competitive supplement); such applications to the SCS program will be returned without review.

Budget and Funding Information

For FY 2009, a maximum of 15 SCS awards will be made.  The amount that can be requested depends on the number of collaborating groups. The PI and one collaborating group may request up to a maximum of $90,000 total annual direct costs. An additional $45,000 can be requested for a second collaborating group, for a maximum of $135,000 total annual direct costs per supplement. Maximum direct costs are exclusive of consortium/contractual Facilities and Administrative (F&A) costs.  The term of the award is up to the duration of the NIGMS-funded grant, which must have at least 18 months of active funding remaining at the time of award of the supplement. These administrative supplements are not renewable.

How to Apply

SCS applications will be accepted on or before the receipt dates listed above (under “Key Dates”).  Each application approved for funding is expected to be awarded within six to eight weeks of the respective receipt date.   Do not send applications to the NIH Center for Scientific Review. 

Applicants are encouraged to submit the request electronically as an email attachment in PDF format to Mr. Jun Moy ( The scanned request must include the signature of the authorized business official.

In lieu of submission by email, applicants may submit one original and two copies of the request packet (with original signatures of the authorized business official) to the NIGMS address listed below:

By U.S. Mail:

Mr. Jun Moy
National Institute of General Medical Sciences
Building 45, 2AN38A
45 Center Drive MSC 6200
Bethesda, MD 20892-6200


Applicants are strongly encouraged to discuss their plans for responding to this Notice with their NIGMS program director.  For additional information or questions, please contact:

Program Contact

Dr. Susan Haynes
National Institute of General Medical Sciences
Building 45, 2AS25J
45 Center Drive MSC 6200
Bethesda, MD 20892-6200
Phone: 301-594-0943


Dr. Marion Zatz
National Institute of General Medical Sciences
Building 45, 2AS25E
45 Center Drive MSC 6200
Bethesda, MD 20892-6200
Phone: 301-594-0943

Grants Management Contact

Mr. Jun Moy
National Institute of General Medical Sciences
Building 45, 2AN38A
45 Center Drive MSC 6200
Bethesda, MD 20892-6200
Phone: 301-594-2761

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