RELEASE DATE:  January 15, 2004

NOTICE:  NOT-ES-04-002

National Institute of Environmental Health Sciences (NIEHS)

The purpose of this notice is to announce a request for proposal 
(RFP NIH-ES-04-01) (http://www.niehs.nih.gov/dert/rcb/rfp.htm). The NIEHS 
is soliciting offers for a contract to study the chemical disposition 
in mammals. The purpose of the project is to obtain detailed chemical 
disposition data from 3 to 6 studies of selected environmental 
contaminants or model compounds per year. Most of these studies will be 
required in laboratory rats (Fischer 344) and/or mice (B6C3F1); however, 
some studies may require other laboratory animals (other rodent species 
or dogs).  Most of the studies will address the disposition of organic 
chemicals or environmental contaminants; however, studies of inorganic 
chemicals may also be requested.  Individual studies may vary in 
complexity from preliminary investigations of chemical absorption to 
detailed studies of all phases of chemical disposition, toxicokinetics, 
and metabolism.  The immediate goal of these studies is to determine 
more accurately the doses for National Toxicology Program (NTP) 
bioassay studies.  The long range goal is the accumulation of data that 
will permit a better assessment of structure-activity for chemical 
absorption, metabolism and disposition in laboratory animals and to 
better interpret the significance of these data to man. A study shall 
consist of the determination of absorption, distribution, metabolism 
and excretion of a selected compound in a given species. Identification 
of unknown metabolites may be complex enough to be considered a 
separate study.  Estimation of toxicokinetic parameters may be 
requested for selected chemicals.  One or more studies per year may be 
requested to investigate the comparative metabolism of chemicals in 
human and rat liver microsomes or hepatocytes in vitro. The compounds 
for study shall be selected and provided by the Project Officer.  
Unless a satisfactory analytical procedure is available for unlabeled 
compounds and both parties agree to its use, radio labeled compounds 
shall be provided to facilitate the assay.  In most instances, the 
initial studies shall be performed in male rats; however, the Project 
Officer shall reserve the right to require studies in female rats or 
additional species.  Male animals are studied initially to avoid the 
influence of estrogenic hormones on xenobiotic metabolizing enzymes.  
The protocol for the study shall be developed by the Principal 
Investigator in cooperation with the Project Officer.  The government 
estimates that the project will require the work of 2 professional man-
years and 3 technical personnel man-years in each contract year.  The 
Principal Investigator and Co-Principal Investigator shall have a 
minimum of 5 years Post-Doctoral Degree experience.  The estimated 
level of effort is 9,980 labor hours.  Award of one cost-reimbursement, 
level of effort contract (the work on the contract involves continuous 
activity with no clearly defined end point).  The contract obtained 
under this solicitation will continue the work of a similar contract, 
N01-ES-95437. The period of performance for the contract is five years, 
beginning on or about October 1, 2004 through September 30, 2009.   
Interested organizations should fax a request for RFP NIH-ES-04-01 to 
the attention of Mr. David Sedgley, Contract Specialist, at (919) 541-
2712 or send an e-mail request to sedgley@niehs.nih.gov.  The 
electronic version of the Fed Biz Ops synopsis will be available on the 
Internet at:  http://www.niehs.nih.gov/dert/rcb/rfp.htm.  An electronic 
copy of the RFP (without the NTP Specifications) will be posted to this 
site on or about January 29, 2004.   All responsible sources may submit 
a proposal which shall be considered by the Agency.  Expected release 
date of the RFP is January 29, 2004 with proposals due March 19, 2003.  
This requirement is unrestricted.  NAICS Code is 541710.

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