Release Date:  April 10, 2002

NOTICE:  NOT-ES-02-009


National Institute of Environmental Health Sciences

The purpose of this contract is to evaluate the toxicologic and 
carcinogenic potential of selected chemicals to which humans are 
exposed in the workplace or at home.  This project include 14-day, 90-
day, 26-Week,  and 2-year studies of 3-Picoline, Cumene Hydroperoxide, 
N,N-Dimethyl-P-Toluidine, Gingko Biloba Extract, and Pyrogallol.  The 
base contract award shall consist of those work activities associated 
with determination of bulk chemical purity and identity, and validation 
of dose formulation/analysis methods, any health and safety concerns 
that must be addressed before study start, and other aspects 
specifically included in Phase 1 for Task 1 (3-Picoline), Task 2 
(Cumene Hydroperoxide), Task 3 (N,N-Dimethyl-p-toluidine),  Task 4 
(Gingko Biloba Extract), and Task 5 (Progallol).  The Government may, 
pending the availability of funds exercise options for: 90-day study 3-
Picoline, a two-year study of 3-Picoline (dosed water)  (Task 1); 14-
Day Study of Cumene Hydroperoxide, 90-day study of Cumene 
Hydroperoxide, 26-Week Study of Cumene Hydroperoxide, and a two-year 
study of Cumene Hydroperoxide (deremal) (Task 2); 90-day study of N,N-
Dimethyl-p-toluidine, a two-year study of N,N-Dimethyl-p-toluidine  
(gavage) (Task 3); 90-day study of Gingko bilobao extract, two-year 
study of Gingko biloba extract (gavage) (Task 4);and 14-Day Study of 
Pyrogallo, 90-Day Study of Pyrogallo, 26-Week Study of Pyrogallol and  
two-year study of Pyrogallol (dermal) (Task 5).  These studies shall be 
conducted according to the Specifications for the Conduct of Studies to 
Evaluate the Toxicologic and Carcinogenic Potential of Selected 
Chemicals in Laboratory Animals for the National Toxicology Program 
(NTP) dated June 2000.  Award of one cost-reimbursement completion 
contract on January 22, 2003, on an open competition basis is 
contemplated as a result of this solicitation.  The estimated level of 
effort is 1,760 labor hours for the base contract and 148,652 labor 
hours for all options.  The estimated period of performance is 
approximately 52 months.  Interested organizations should request 
either a streamlined or full RFP package by written, telephonic (919) 
541-7596), or telefax request (919-541-2712).  If no selection is made, 
a streamlined version of the RFP will be provided, which will include 
only the Statement of Work, deliverables and reporting requirements, 
any special requirements, mandatory qualifications, and technical 
evaluation criteria.  After examination of the streamlined RFP, any 
organization interested in responding to this RFP must request the full 
RFP package.  A copy of the streamlined and full RFP (with Statement of 
Work only) will be available after the release date on the Internet at  Those individuals who wish 
to access the on-line version should follow the instructions provided 
in the on-line solicitation package.  All responsible sources may 
submit a proposal which shall be considered by the Agency.  Expected 
release date of the RFP is April 24, 2002 with proposals due June 13, 

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