Release Date:  July 31, 2000

NOTICE:  ES-00-004

RFP:  NIH-ES-00-28

National Institute of Environmental Health Sciences

The NIEHS is soliciting offers for a contract that involves the evaluation of 
the toxic and carcinogenic potential of selected chemical agents used as 
dietary supplements and/or herbal medicine.  This project includes 90-day and 
2-year studies of Chromium Picollinate, Goldenseal, Milk Thistle, Thujone, and 
Androstenedione.  The base contract will consist of Phase 1 for all five 
chemicals to include those work activities associated with the determination 
of bulk chemical purity and identity, and validation of dose 
formulation/analysis methods, any health and safety concerns that must be 
addressed before study start, and only those other aspects specifically 
included in Phase 1.  Upon successful completion of Phase 1, the Government 
may unilaterally exercise options for the conduct of 90-day and 2-year studies 
specified in Phase 2 and 3.  These studies shall be conducted according to the 
Specifications for the Conduct of Studies to Evaluate the Toxic and 
Carcinogenic Potential of Chemical, Biological and Physical Agents in 
Laboratory Animals for the National Toxicology Program dated August, 1992, 
with subsequent revisions.  Offerors shall have a working laboratory involved 
in conducting studies by gavage administration in place by the date of 
proposal submission.  The Principal Investigator, Toxicologist, Chemist, 
Health and Safety Officer and Quality Assurance Officer shall be employees of 
the contract laboratory (i.e., not consultants or subcontractors).  The daily 
interaction and constant coordination of efforts needed amongst these 
discipline areas throughout the in-life portion of the studies makes it 
critical that they be physically and organizationally together.  Award of one 
cost-reimbursement, completion type contract on May 31, 2001 on level of 
effort is 1,400 labor hours for the base contract and 127,250 labor hours for 
all options.  The estimated period of performance is approximately seven 
months for the base contract and four years four months if all options are 
exercised.  Interested organizations should request either a streamlined or 
full RFP package.  If no selection is made, a streamlined version of the RFP 
will be provided, which will include only the Statement of Work, deliverables 
and reporting requirements, special requirements, mandatory qualifications, 
and technical evaluation criteria.  After examination of these documents, any 
organization interested in responding to this RFP must request the entire RFP 
by written, telephonic (919) 541-7596), or telefax request (919) 541-2712.  
The electronic version of the CBD synopsis and the RFP (which will be 
available on or about July 31, 2000 with the NTP specifications) will be 
available on the Internet at:  All 
responsible sources may submit a proposal which shall be considered by the 
Agency.  Expected release date of the RFP is July 31, 2000 with proposals due 
September 30, 2000.

Request should reference RFP NIH-ES-00-28 and should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
Attn: Jacqueline A. Osgood
79 T. W. Alexander Drive, 4401 Building
P.O. Box 12874
Research Triangle Park, NC 27709

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