COMPLEX CHEMICAL MIXTURES INTERAGENCY ANNOUNCEMENT 2000 SCIENCE TO ACHIEVE RESULTS (STAR) PROGRAM Release Date: April 24, 2000 Closing Date: July 10, 2000 NOTICE: ES-00-003 U.S. Environmental Protection Agency National Institute of Environmental Health Sciences National Institute for Occupational Safety and Health This announcement is a collaborative effort between the U.S. Environmental Protection Agency and the Department of Health and Human Services (National Institute of Environmental Health Sciences and National Institute for Occupational Safety and Health). The purpose of this announcement is to stimulate innovative experimental approaches and computational, statistical, or predictive strategies for assessing the impact of chemical mixtures that focus on the mechanistic basis for chemical interactions and related health effects. The National Institute of Environmental Health Sciences (NIEHS) supports research that examines human health consequences of exposure to physical and chemical toxicants in the environment as well as the underlying mechanisms involved in environmentally related disease and dysfunction. NIEHS is interested in understanding what mixtures of chemicals the public is exposed to as well as the mechanisms involved in the interaction of these mixtures and subsequent health effects. The development of predictive computational and statistical tools that incorporates mechanistic information and can be applied to risk assessment is of particular interest. The research needs identified in this announcement relevant to the National Institute for Occupational Safety and Health (NIOSH) are consistent with the National Occupational Research Agenda (NORA) developed by NIOSH and partners in the public and private sectors to provide a framework to guide occupational safety and health research into the next decade. There are 21 research priority areas identified in NORA, however, the area with specific relevance to this announcement is "Mixed Exposures." Exposures to combinations of chemical or physical agents is common in many occupations, but knowledge about the potential health effects of such exposures is limited. Thus, NIOSH is interested in studies that identify synergistic effects of multiple exposure, improve characterization of worker exposures to mixtures, or improve laboratory and statistical analysis methods. Information about this RFA can be obtained on the US EPA homepage at: http://es.epa.gov/ncerqa/rfa/mixtures00.html. Applications should be sent to the U.S. EPA. no later than 4:00 P.M. ET on July 10, 2000. INQUIRIES For additional information about this RFA, contact: Dr. Claudia Thompson, Ph.D. Scientific Program Administrator Chemical Exposures and Molecular Biology Branch Office of Program Development National Institute of Environmental Health Sciences P.O. Box 12233, MD EC-21 Research Triangle Park, NC 27709 Telephone: (919) 541-4638 Fax: (919) 316-4606 Email: thompso1@niehs.nih.gov or Michael Galvin, Jr., Ph.D. Research Grants Program National Institute for Occupational Safety and Health 1600 Clifton Road, NE Building 1, Room 3043, MS D30 Atlanta, GA 30333 Telephone: (404) 639-1533 Fax: (404) 639-4616 Email: mtg3@cdc.gov
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