and Human Services (HHS)
INTERAGENCY OPPORTUNITIES IN MULTI-SCALE MODELING IN BIOMEDICAL,
BIOLOGICAL, AND BEHAVIORAL SYSTEMS NSF 04-607
RELEASE DATE: August 20, 2004
NOTICE: NOT-EB-04-002
PARTICIPATING ORGANIZATIONS:
National Science Foundation (NSF)
(http://www.nsf.gov)
Directorate for Engineering
Division of Bioengineering and Environmental Systems
Division of Civil and Mechanical Systems
Division of Chemical and Transport Systems
Division of Design, Manufacture and Industrial Innovation
Division of Electrical and Communications Systems
Directorate for Computer and Information Science and Engineering
Division of Shared Cyberinfrastructure
Directorate for Mathematical and Physical Sciences
Division of Mathematical Sciences
National Institutes of Health (NIH)
(http://www.nih.gov)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
(http://www.nibib.nih.gov)
National Cancer Institute (NCI)
(http://www.nci.nih.gov/)
National Institute of Child Health and Human Development (NICHD)
(http://www.nichd.nih.gov/)
National Institute on Drug Abuse (NIDA)
(http://www.nida.nih.gov)
National Institute of Environmental Health Sciences (NIEHS)
(http://www.niehs.nih.gov/)
National Institute of General Medical Sciences (NIGMS)
(http://www.nigms.nih.gov/)
National Institute of Neurological Disorders and Stroke (NINDS)
(http://www.ninds.nih.gov)
National Library of Medicine (NLM)
(http://www.nlm.nih.gov/)
National Aeronautics and Space Administration
(http://www.nasa.gov)
Bioastronautics Research Division
U.S. Dept. of Energy
(http://www.energy.gov)
Office of Science, Office of Biological and Environmental Research
Office of Science, Office of Advanced Scientific Computing Research
LETTER OF INTENT RECEIPT DATE: September 22, 2004
PROPOSAL (APPLICATION) RECEIPT DATE: November 09, 2004 (due by 5 p.m.
proposer's local time)
This Notice announces a joint initiative, Interagency Opportunities in
Multi-Scale Modeling in Biomedical, Biological, and Behavioral Systems,
between three National Science Foundation (NSF) Directorates, eight
participating National Institutes of Health (NIH) Institutes, the
Bioastronautics Research Division of the National Aeronautics and Space
Administration (NASA) and two offices in the U.S. Department of Energy
(DOE).
This NIH program announcement is released under NSF 04-607
solicitation, http://www.nsf.gov/pubs/2004/nsf04607/nsf04607.htm.
This solicitation provides an opportunity for an interagency granting
activity to promote the development and dissemination of tools to
enhance computational modeling of biological, biomedical and behavioral
sciences at multiple scales ranging from the molecular to population.
Multiple agencies are providing research funding in support of this
solicitation. Appropriate scientific areas of investigations are those
that are currently supported by NSF, NIH, NASA and DOE, or related to
the missions of the four agencies.
The intent of this interagency solicitation is to encourage the
integrative systems engineering approach to multi-scale modeling,
combining theoretical and computational approaches to: 1) Formulate and
validate novel computational and statistical methods and relationships
for spanning multiple scales, 2) Discover and/or investigate
intermediate levels of organization above and below the currently
established level of modeling expertise, 3) Form novel collaborations
among the research community focused on expanding the breadth of multi-
scale modeling activities, 4) Produce models applicable to biological
processes, diseases, environmental exposures and human behavior
patterns that can be tangibly demonstrated to be of practical utility
to the community at large for research or educational purposes, 5) Form
a Consortium of Investigators for the purposes of information exchange,
encouraging model intraoperability, model demonstration and evaluation,
and discussion of critical issues pertaining to multi-scale modeling,
and 6) Form a platform for open source software sharing.
Multi-scale modeling deals with spanning scales from molecular to
population and is expected to largely impact the understanding of
biological processes and also further the predictive capability in
biological, biomedical and environmental systems. This is a nascent
research effort in biology; hence the modeling research that will be
supported under this initiative must have an impact on systems at least
on two levels of scale. It is expected that: 1) Proposals will include
establishing new collaborations between computational and/or modeling
experts who have traditionally focused their models on the same system,
but at different scales; or collaborations between computational and/or
modeling experts and experimentalists currently working on a single
experimental scale but for whom a multi-scale approach would be an
appropriate complement to their ongoing research, 2) New and novel
theories and modeling approaches will be developed to bridge across
scales, and 3) The development of the multi-scale model will bring
about new understanding of a system that would not have otherwise been
achieved without the model. Proposals not meeting these three
requirements will be returned without review. High priority will be
given to projects that deal directly and explicitly with how to link
multiple scales, as opposed to projects that deal with multiple scales
separately.
AWARD INFORMATION
The total estimated amount of funding available for inter-agency multi-
scale modeling support is approximately $15,000,000 over the 3 year
granting period. However, Agencies have no obligation to provide this
amount of support if the quality of the proposals received does not
justify such expenditure, and/or sufficient funds are not available.
Award sizes are expected to range from $100,000 to $500,000 in total
costs per year (including indirect costs), with durations up to three
years. Most awards will be on the smaller end of this range.
Estimated program budget, number of awards, and average award size and
duration are subject to the availability of funds and the receipt of
meritorious applications. Since the proposals will be submitted
originally in the NSF format, they will not use the modular budget
format currently used by the NIH. The maximum budgets of awards funded
by the NIH will be $250,000 per year in direct costs. The maximum
budgets of awards funded by NSF will be $375,000 per year in total
costs. The maximum budgets of awards funded by NASA will be $500,000
per year total cost. The maximum budget of awards funded by DOE will
be $500,000 per year in total costs.
Upon conclusion of the multi-agency review process, meritorious
applications may be recommended for funding by either the participating
NSF Directorates, NIH Institutes, NASA Division, or DOE Offices at the
option of the agencies, not the applicant.
PROPOSAL PREPARATION AND SUBMISSION INSTRUCTIONS
Letters of Intent (Required): Proposals submitted without a Letter of
Intent will be returned without review.
Letters of intent must be submitted via the NSF Fastlane system
(www.fastlane.nsf.gov). The letter of intent submission must include:
1. The names and institutions/organizations of PIs, Co-PIs, and maximum
5 senior personnel
2. The title of the proposal
3. A 2500-character synopsis (abstract) of the proposal
4. An initial request for primary and secondary assignments, i.e., NSF
Division, NIH Institute, NASA or DOE
5. The name of the program officer(s) who has expressed an interest in
the project (see Agency Contacts listed in this Solicitation).
Letters of intent will be used by the program to guide the selection of
reviewers. PIs should not expect feedback on their letters of intent,
beyond acknowledgment of their receipt.
Full Application Instructions:
Proposals submitted in response to this program
announcement/solicitation should be prepared and submitted in
accordance with the general guidelines contained in the NSF Grant
Proposal Guide (GPG). The complete text of the GPG is available
electronically on the NSF Website at:
http://www.nsf.gov/cgi-bin/getpub?gpg. Paper copies of the GPG may be
obtained from the NSF Publications Clearinghouse, telephone (703) 292-7827
or by e-mail from [email protected].
Proposers are required to indicate in the Project Summary which of the
Participating Agencies or Departments has expressed an interest in
their project. Proposers are expected to prepare their proposals
keeping in mind the budget limitations and review criteria specific to
their agencies of interest (see Section VI of the NSF solicitation at
http://www.nsf.gov/pubs/2004/nsf04607/nsf04607.htm).
The proposal must include written statements signed by the officials of
the proposing organizations responsible for intellectual property
issues, that the organization supports and agrees to abide by the
software dissemination plans put forth in the proposal (see Section II
of the NSF solicitation at
http://www.nsf.gov/pubs/2004/nsf04607/nsf04607.htm). These should be
submitted as supplementary documents in the FastLane proposal.
Proposers are reminded to identify the program
announcement/solicitation number (04-607) in the program
announcement/solicitation block on the proposal Cover Sheet. Compliance
with this requirement is critical to determining the relevant proposal
processing guidelines. Failure to submit this information may delay
processing.
INQUIRIES
Written and telephone inquiries are strongly encouraged. Please see
the NSF program announcement for names and contact information for the
cognizant program officials in the participating agencies at
http://www.nsf.gov/pubs/2004/nsf04607/nsf04607.htm).
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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