NIDDK ADMINISTRATIVE SUPPLEMENTS FOR HUMAN EMBRYONIC CELL LINE RESEARCH

RELEASE DATE:  December 12, 2002

NOTICE:  NOT-DK-03-002

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 (http://www.niddk.nih.gov)

The National Institute of Diabetes and Digestive and Kidney Diseases 
(NIDDK) announces the availability of administrative supplements to 
NIDDK grantees to conduct research using human embryonic stem cell 
(hESC) lines.  The purpose of these supplements is to enable NIDDK 
grantees with little or no prior experience working with hESCs to 
explore the use of hESC as a model system to further research that is 
directly related to the aims of the parent grant.  The supplemental 
funds also may be used to foster scientific collaborations between 
investigators established in the use of hESCs and current NIDDK 
investigators with little or no experience in their use.  Potential 
applicants are strongly encouraged to contact NIDDK staff to discuss 
potential supplemental requests at an early stage of the application 
process.  The cell line used must be listed on the NIH Registry of hESC 
lines (http://escr.nih.gov).

NIDDK-funded investigators may request up to $75,000 in direct costs 
for a period of up to one year.  The parent grant must have at least 
one year of funding remaining at the time of the supplement award.  For 
requests for scientific collaboration support, the one-year, $75,000 
cap still applies, and the application must be submitted by an NIDDK 
grantee.

The work proposed must be within the scope of the research recommended 
by peer review.  For example, investigators carrying out animal ES or 
nonembryonic human adult stem cell work may elect to request funding to 
extend their investigations to hESC lines.  Investigators with current 
NIDDK grant support in related areas may also apply.  However, in all 
cases careful explanation and justification must be included to 
document that the proposed work is within the scope of an existing, 
funded application.  

Investigators must independently contact the hESC line providers listed 
on the NIH Registry and make arrangements including any required 
material transfer agreements (MTA) so the hESC line can be obtained.  
Applicants must state which hESC line or lines will be used and include 
a letter from the provider stating that the provider will supply the 
hESC line.  The investigators should also demonstrate either prior 
experience that may be applied to work with hESC lines or an outline of 
plans for obtaining expertise to culture hESCs.  The hESC line 
providers, other laboratories with hESC experience, or laboratory 
training courses on hESC methods are potential means of obtaining this 
training.  Other means for acquiring hESC expertise may be proposed.

There will be two receipt dates for administrative supplement 
applications in 2003: February 18 and July 1.  Awards will be made 
depending on the receipt of a sufficient number of qualified 
applications and the availability of funds.  

To apply for an administrative supplement, send an original letter and 
one copy countersigned by the grantee institution's authorized business 
official to Drs. Badman, Karp or Sato at the addresses below.  The 
letter (5 page limit) must include: 1) an abstract of the proposed 
supplemental activity and how it is related to the parent grant; 2) 
expected overall impact of the requested supplement on ongoing research 
results; 3) the NIH code for the hESC line(s)and a letter from the 
provider indicating the provider(s) will supply the cell line(s); 4) a 
justification of budget request and funding period; and 5) current 
contact information for the principal investigator, including telephone 
number and mailing and e-mail addresses.  Although these descriptions 
should be as concise as possible, sufficient detail must be provided to 
allow the NIDDK to determine if the request qualifies as an 
administrative supplement.

NIDDK will consider supplement requests from all eligible applicants.  
Requests will be evaluated according to the following criteria:

o The proposed research falls within the scope of the parent grant and 
is a logical extension of the goals and objectives, but not 
sufficiently different to constitute new research or program expansion.

o Evidence of prior ability to work with hESC lines or an outline of 
plans for obtaining expertise to culture hESCs.  

o Documentation and justification of the requested budget.

Supplement requests will be reviewed by a committee of NIDDK program 
staff.  Award decisions will be based upon the criteria provided above, 
availability of funds, and NIDDK programmatic priorities and balance. 

Direct inquiries regarding program issues to:

Dr. David G. Badman
Division of Kidney, Urologic, and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd., Rm. 621, MSC 5458
5458, Bethesda, MD 20892-5458
(For FedEx and UPS, use Bethesda, MD 20817)
Phone: (301) 594-7717
Fax: 301-480-3510
Email: db70f@nih.gov

Dr. Robert W. Karp
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Room 671, MSC 5450
Bethesda, MD 20892-5450
(For FedEx and UPS, use Bethesda, MD 20817)
301-451-8875  
Fax: 301-480-8300
Email: karpr@extra.niddk.nih.gov

Dr. Sheryl Sato
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases/NIH
6707 Democracy Plaza, Room 6105, MSC 5460
Bethesda, MD 20892-5460
(For FedEx and UPS, use Bethesda, MD 20817)
Phone: (301) 594-8811
Fax: (301) 480-3503
Email: satos@extra.nddk.nih.gov

Direct inquiries regarding fiscal issues to: 

Teresa Farris Marquette 
Senior Grants Management Specialist 
NIDDK/DEA/GMB 
Two Democracy Plaza, Room 728, MSC 5452 
6707 Democracy Blvd. 
Bethesda, MD 20892-5452
(For Courier service, use Zip Code 20817) 
Phone: (301) 594-7682  
Fax: (301) 480-3504  
Email: FarrisT@extra.niddk.nih.gov

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