Notice Number: NOT-DA-14-037
Key Dates
Release Date: November 14, 2013
None
Issued by
National Institute on Drug Abuse (NIDA)
Purpose
The National Institute on Drug Abuse (NIDA) will solicit proposals from qualified organizations to perform non-clinical ADME (Absorption, Distribution, Metabolism, and Excretion) studies in support of its medications development program. A solicitation will be released through the Federal Business Opportunities website (https://www.fbo.gov/). The RFP will be released on or about December 2, 2013 and proposals will be due approximately 45 days thereafter.
Research Initiative Details
In this effort, the contractor will be required to:
(1) Conduct the following studies: Bioavailability and pharmacokinetic, mass balance, tissue distribution, and toxicokinetic analysis of new potential medications;
(2) Provide analytical services such as structure identification of major metabolites by mass spectrometry or Nuclear Magnetic Resonance (NMR);
(3) Develop specific assays for a potential medication and its metabolites in biological matrices;
(4) Use the following experimental designs and processes when conducting research on potential medications: (E.G. High Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), Liquid Chromatography with Tandem Mass Spectrometry (LC/MS/MS), and Gas Chromatograph-Mass Spectrometry (GC-MS);
(5) Abide by the Controlled Substances Act of 1970 and possess a DEA Registration for Chemical Analysis or Research Registration for Schedules II to V; and
(6) Demonstrate the capability to obtain a DEA registration for Schedule I controlled substances.
Inquiries
Please direct all inquiries to:
Patrick Kenney
National Institute on Drug Abuse (NIDA)
Telephone: 301-443-6677
Email: Patrick.kenney@nih.gov
and Human Services (HHS)
