Release Date: April 3, 2012
National Institute on Drug Abuse (NIDA))
The Genetics and Molecular Neurobiology Research Branch (GMNRB) at the National Institute on Drug Abuse (NIDA) seeks applications using the JAX Diversity Outcross (DO) mice to identify genetic variants associated with substance abuse and addiction as well as treatment response. To apply for grants within this area of interest, refer to PA-11-026 Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-026.html).
The diversity outcross mice permit fine mapping of genetic loci for complex trait with far less effort and greater resolution than before with other mouse resources. Papers highlighting this resource can be found in the Feb 16, 2012 issues of Genetics www.genetics.org and G3: Genes|Genomes|Genetics www.g3journal.org.
Identification the gene variants underlying the following traits DO mice that are of interest to GMNRB include but are not limited to:
The JAX:DO are available from The Jackson Laboratory (Bar Harbor, ME), as JAXMice stock number 009376. Sibling information at each generation is tracked and made available upon request. http://cgd.jax.org/datasets/phenotype/SvensonDO.shtml.
If interested in developing an application please contact Dr. Jonathan Pollock.
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