Release Date:  March 12, 2001

NOTICE:  NOT-DA-01-024


National Institute on Drug Abuse

The National Institute on Drug Abuse is soliciting proposals from qualified 
individuals or organizations having the capability to design, synthesize, and 
scale-up compounds which affect primarily dopaminergic systems and either 
substitute for cocaine, antagonize its effects, and/or prevent relapse.  The 
project shall involve the synthesis of monoamine uptake inhibitors of one or 
more of the following types:  selective dopamine uptake inhibitors; compounds 
which affect dopaminergic systems through the inhibition of dopamine and 
serotonin transporters; compounds of novel structures which show nonselective 
inhibition of dopamine, serotonin, and norepinephrine transporters; and, 
dopamine receptor modulators (partial agonists, full agonists, antagonists and 
functional cocaine antagonists).  The project shall also provide for the 
scale-up production, and analog synthesis, of promising compounds.    The 
major goal of this project is to provide NIDA with a resource of novel 
compounds, and compounds in sufficient quantities for testing, which have 
potential use in the treatment of cocaine abuse.  It is anticipated that five 
(5) cost reimbursement, level of effort (term) type contracts will be awarded 
for a base period of two years, with the potential of three one-year options. 
Three of the five contracts will be set aside for small businesses under NAICS 
325411.  RFP No. N01DA-1-8815 will be available electronically on or about 
April 5, 2001, and may be accessed through the NIDA website at the following 
address: (URL:  Please note that 
the RFP for this acquisition will be streamlined to include only the Work 
Statement, Deliverables and Reporting Requirements, Special Requirements and 
Mandatory Qualifications, Technical Evaluation Criteria, and other necessary 
Proposal Preparation Instructions.  All information required for the 
submission of an offer will be contained in or accessible through the 
electronic RFP package.  Response to the RFP will be due on or about May 22, 
2001.  Any responsible offeror may submit a proposal which will be considered 
by the Government.  This advertisement does not commit the Government to award 
a contract.

Point of Contact:	Kenneth E. Goodling, Contracting Officer
National Institute on Drug Abuse, NIH
Contracts Management Branch, OPRM
6001 Executive Blvd., Room 3105, MSC 9543
Bethesda, Maryland 20892-9543
Electronic Mail Address:
Telephone: (301) 443-6677
Fax: (301) 443-7595 

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