Notice of Intent to Publish a Notice of Funding Opportunity for Global Training for Research and Equity in Cancer (GlobTREC) (U2R Clinical Trial Optional)
Notice Number:
NOT-CA-25-028

Key Dates

Release Date:
January 10, 2025
Estimated Publication Date of Notice of Funding Opportunity :
February 28, 2025
First Estimated Application Due Date:
July 14, 2025
Earliest Estimated Award Date:
March 02, 2026
Earliest Estimated Start Date:
April 03, 2026
Related Announcements

None

Issued by

National Cancer Institute (NCI)

Purpose

The National Cancer Institute (NCI) intends to publish a Notice of Funding Opportunity (NOFO) as a Request for Applications (RFA) that will invite applications from institutions who propose research training programs to strengthen capacity to conduct global cancer research. The overarching goal of this research training program is to provide investigators and health professionals with the scientific expertise, mentorship, and leadership skills needed to conduct innovative and collaborative global research projects that will contribute to the advancement of basic, clinical, translational, and population-based cancer research.  This Notice is being provided to allow potential applicants time to develop responsive projects and meaningful collaborations.

The NOFO is expected to be published in the early part of the 2025 calendar year with three expected application due dates in summer of 2025, 2026 and 2027 respectively. 

The NOFO will utilize the U2R activity code, which is an NIH cooperative agreement mechanism for international research training. Details of the planned NOFO are provided below.

Research Initiative Details

Cancer is among the leading causes of death worldwide. By 2040, the number of new cancer cases per year is expected to rise to 29.9 million and the number of cancer-related deaths to 15.3 million. Most cancer worldwide occurs in and low-and middle-income countries (LMICs). Over 50% of incident cancers and 70% of cancer deaths occur in these settings and this proportion is increasing.  Research in these settings provides opportunities to address the global burden, generate new knowledge and approaches, and inform efforts to address inequities across diverse settings. The primary drivers of these disparities – environmental and behavioral exposures, inadequate prevention and early detection, presence of comorbidities, and limited access to diagnosis and treatment services – also underlie the high cancer-related morbidity and mortality experienced by some population groups in high-income countries. 

In this initiative, NCI continues its institutional training program to support global cancer research. This program is designed to strengthen the global cancer research community through support of training programs built upon preexisting, high-quality cancer research and training infrastructure and strong institutional partnerships

Principal Investigators (PIs) and contact PIs will be either from a U.S.-based institution or an institution based in a low- and middle-income country (LMIC).  LMICs are defined by the World Bank classification system according to Gross National Income (GNI) per capita as “low-income,” “lower-middle-income,” and “upper-middle-income” (http://data.worldbank.org/about/country-classifications/country-and-lending-groups).

PIs should demonstrate prior or ongoing programs to develop cancer research capacity indicating their commitment to developing research workforce in the LMICs and in the US for global oncology research.   NCI strongly encourages cross-country and cross-regional collaborations. 

Funding Information

Estimated Total Funding

Up to $0.9 million in FY2026

Expected Number of Awards

4

Estimated Award Ceiling

U2R application direct costs are limited to $275,000 per year over a five-year period, Indirect costs are capped at 8%

Primary Assistance Listing Number(s)

93.398

Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Non-domestic (non-U.S.) Entity (Foreign Organization)

Applications are not being solicited at this time. 

Inquiries

Please direct all inquiries to:

Sudha Sivaram, DrPH
National Cancer Institute (NCI)
Telephone: 240-276-5804
Email: [email protected]