NOT-CA-24-086: Notice of Intent to Publish a Funding Opportunity Announcement for NCI National Clinical Trials Network - Network Lead Academic Participating Sites (UG1 Clinical Trial Not Allowed)

Notice of Intent to Publish a Funding Opportunity Announcement for NCI National Clinical Trials Network - Network Lead Academic Participating Sites (UG1 Clinical Trial Not Allowed)

Notice Number:

NOT-CA-24-086

Key Dates

Release Date:

July 22, 2024

Estimated Publication Date of Notice of Funding Opportunity :

September 25, 2024

First Estimated Application Due Date:

February 24, 2025

Earliest Estimated Award Date:

March 01, 2026

Earliest Estimated Start Date:

March 01, 2026

Related Announcements

None

Issued by

National Cancer Institute (NCI)

Purpose

The National Cancer Institute (NCI) intends to issue a UG1 NCI National Clinical Trials Network (NCTN) – Network Lead Academic Participating Sites notice of funding opportunity (NOFO). The NCTN Network Lead Academic Participating Sites will provide scientific leadership by helping to develop and conduct clinical trials in association with one or more adult Network Groups and will contribute substantial accrual to clinical trials conducted across the entire NCTN. The primary goal of the NCTN is the conduct of multi-center, late-phase, clinical treatment trials (i.e., randomized phase 2 and phase 3 trials) and advanced imaging trials across a broad range of cancers, modalities, and diverse patient populations as part of the NCI's overall clinical research program for adults, adolescents and young adults, and children with cancer. The NCTN also conducts, as necessary, preliminary studies needed for development of definitive trials, especially umbrella/basket trials and rare tumor trials, when an extensive, national patient catchment area is required.

This Notice of Intent to Publish is being provided to allow sufficient time for applicants to develop strong applications.
The NOFO is expected to be published in Fall 2024 with only one expected application due date in late February 2025.

Research Initiative Details

This Notice encourages investigators who provide scientific expertise and leadership in the development and conduct of NCTN cancer treatment trials and whose institution can provide robust accrual to NCTN trials across the Network, including accrual to rare cancers and accrual from special populations, to begin to consider applying for this NOFO. Among the areas of research encouraged in this initiative are collaboration and participation in NCTN initiatives and mentoring of junior investigators in the full spectrum of NCTN clinical trial activities.

Funding Information

Estimated Total Funding

NCI intends to commit $35.1 million in FY 2026

Expected Number of Awards

32 to 40

Estimated Award Ceiling

Application budgets are limited to no more than $1.7 in direct costs per year. The total project period requested may not exceed 6 years.

Primary Assistance Listing Number(s)

93.394, 93.395

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government

Applications are not being solicited at this time.

Inquiries

Please direct all inquiries to:

Margaret Mooney, M.D.
National Cancer Institute (NCI)
Telephone: 240-276-6006
Email: NCINCTNRFA@mail.nih.gov