Notice of Availability of Administrative Supplements for U.S. - China Biomedical Collaborative Research on Cancer, Allergy, Immunology, and Infectious Diseases including HIV/AIDS and its Co-morbidities


Notice Number:  NOT-CA-11-003

Key Dates

Release Date:  February 4, 2011
Optional Letters of Intent Due: March 14, 2011
Supplement Application Due: April 14, 2011
Award Date: September 30, 2011

Issued by

National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)

Purpose

The National Institutes of Health (NIH) of the United States (U.S.) Department of Health and Human Services (HHS) supports international collaborative biomedical research to advance science and expand biomedical knowledge. Scientific cooperation between the U.S. and the People’s Republic of China was initiated over 30 years ago and has grown rapidly in recent years. Recognizing that enhanced cooperative biomedical research would be of mutual benefit to the U.S. and China, the NIH Director and the President of the National Natural Science Foundation of China (NSFC) signed a Memorandum of Understanding (MOU) in October 2010.

NIH and NSFC further signed an Implementing Arrangement (IA) in December 2010 to develop a new U.S.-China Program for Biomedical Research Cooperation. A Joint Working Group (JWG), made up of a specified number of members from both NIH and NSFC, will develop strategic plans for collaboration and facilitate the expedited review and clearance of proposed bilateral projects. Both the NIH and NSFC have allocated funds to support joint activities pursued under this program.

This Notice announces an opportunity for eligible NIH grantees to request administrative supplement support (additional funds to a grant or cooperative agreement for unexpected administrative expenses within the approved project scope) for their eligible active grants to enhance ongoing research efforts through collaborations with Chinese scientists under the new U.S.-China Program for Biomedical Research Cooperation. Based on the merit of the requests received and the availability of funds, the NIH may award up to $3,000,000 (total costs) in FY2011 for this effort, and the NSFC has pledged to provide complementary funding to support the Chinese co-investigators involved in the research collaborations.

U.S. and Chinese collaborating investigators (referred to as co-investigators in this announcement) should work together to submit corresponding applications in response to this announcement to NIH and NSFC. By sending an application in to NIH, the applicant in turn agrees to provide directly a complete copy of the application to their Chinese counterpart. The NIH will not consider for funding any application that has not met this sharing requirement. Potential U.S. applicants concerned about confidentiality or proprietary information should take this requirement into account before deciding what information to submit in their application to NIH. Applications from U.S. co-investigators will be submitted in response to this funding announcement and reviewed administratively at NIH. NSFC will publish a corresponding funding announcement (in Chinese) for Chinese co-investigators to apply for funding under the joint U.S.-China Program in Biomedical Research Cooperation (see http://www.nsfc.gov.cn/Portal0/InfoModule_396/More.htm). Applications from Chinese co-investigators will be reviewed in parallel by NSFC using selection factors that are harmonized with NIH selection factors. Chinese applicants will also be required to submit as part of their applications a copy of the NIH application provided by their U.S. collaborator. Therefore, it is expected that the Chinese collaborator will contact the U.S. PD/PI and request copies of their application in response to this announcement for submission. This application will also be reviewed confidentially during the NSFC review process. Funding decisions will be made by NIH and NSFC in consultation with the JWG and with consideration of the research priorities of both countries.

Research Objectives

Under this program, the NIH will support meritorious administrative supplements to existing NCI and NIAID grants as well as any NIH grants in the area of HIV/AIDS and its co-morbidities. These grants must have at least one year of active funding remaining at the time of the administrative supplement award on September 30, 2011. Funding under this program can be used to support new, previously unforeseen research opportunities enhancing existing grants through collaboration between U.S. and Chinese scientists. The proposed research must be within the peer-reviewed scope of the NIH-supported parent grant. NSFC will provide complementary funds as new research grants to scientists who are current or former NSFC grantees to support the Chinese co-investigators for these collaborative projects.

The intent of this initiative is to foster, stimulate, and/or expand collaborative basic, translational, and applied research between eligible NIH grantees and eligible Chinese researchers in the areas of cancer, allergy, immunology, and infectious diseases including HIV/AIDS and its co-morbidities.

Basic, translational, behavioral, clinical, preventive, or epidemiological research may be proposed under this program. Clinical trials of drugs, biologics or diagnostics will NOT be supported through this program. Examples of research areas that are responsive to this announcement include, but are not limited to:

In cancer:

In allergy, immunology, and infectious diseases:

Budget and Funding Information

Up to $3,000,000 (total costs) will be available in Fiscal Year 2011.

Administrative supplements will be limited to 25 percent of the Institute Advisory Council-approved direct costs for the current budget year of the project or $100,000 direct costs, whichever is less. Awards will be for one year and the existing grant must have at least one (1) year of active funding remaining at the time that the supplement is awarded on September 30, 2011.

NSFC will provide complementary funds (approximately 300,000 Renminbi (Chinese currency) per project) for the Chinese co-investigators to engage in these projects. Five percent of the NSFC total award amounts can be used for indirect costs by Chinese institutions.

Eligibility

To be eligible, the parent NIH grant must be active, and the research proposed in the supplement must be accomplished within the remaining time of the award. The proposed supplement must be within the general scope of the peer-reviewed activities and aims approved within the parent grant. Current NCI or NIAID grantees funded in cancer, allergy, immunology, infectious diseases, and HIV/AIDS and its co-morbidities with at least one (1) year of active funding remaining as of September 30, 2011, are eligible to apply. Grantees at other NIH institutes funded in the area of HIV/AIDS and its co-morbidities are also eligible. Funding under this program will support collaborative research projects only and cannot be used to support research infrastructure. Funding under this program can be used to support new, previously unforeseen research opportunities enhancing existing grants through collaboration between U.S. and Chinese scientists. The proposed research must be within the peer-reviewed scope of the NIH-supported parent grant. . Applicants must propose to work with Chinese scientists who are current or former NSFC grantees. NSFC has additional eligibility requirements for Chinese co-investigators to apply for NSFC funding under this program which are described in detail in the corresponding NSFC funding announcement published on its website at www.nsfc.gov.cn (only in Chinese). Applications are only responsive to this announcement if the Chinese co-investigator submits a corresponding application to NSFC. The NIH grant mechanisms eligible under this announcement are: active R01; P01; U01; U19; U54; P30 (as pilot projects to the Developmental Core with no additional funding to infrastructure); and P50 awards.

IMPORTANT: The research proposed by the NIH grantee in the administrative supplement request must be within the original scope of the NIH-supported parent grant. The funding mechanism being used to support this program, i.e., administrative supplements, can be used to cover increased cost associated with achieving certain new research objectives as long as they are within the original scope of the parent grant

Eligible Chinese co-investigators may propose a new project in the corresponding application to NSFC, as NSFC will grant new, 1-year awards under the jointly funded program.

Applicants are encouraged to ensure that each administrative supplement request includes two budgets: one requesting NIH funding (for expenses on the U.S. side) and one budget requesting NSFC funding (for expenses on the Chinese side in Chinese currency). Both the U.S. and Chinese applications should include the same title for the collaborative project written in English.

Letters of Interest (Only for U.S. Investigators)

Letters of Interest (LOIs) are optional and non-binding. Before submitting an LOI, U.S. applicants are strongly encouraged to discuss the feasibility of their research application with the program officer or project scientist of the parent grant. LOIs should be no longer than two pages and should include the following information:

LOIs should be sent by e-mail to:

For NCI:
Bryan Baker
E-mail: bb117a@nih.gov

For NIAID:
Maggie Wells
E-mail: mw509s@nih.gov

For administrative supplement requests to other NIH Institutes and Centers in the area of HIV/AIDS and its co-morbidities:

Robert W. Eisinger, Ph.D.
E-mail: be4y@nih.gov 

LOIs may be submitted at any time, but must be received at the NIH no later than 5:00PM Eastern Time on March 14, 2011.

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, the request must be signed by the Authorized Organizational Representative/Signing Official (AOR/SO) and the PD/PI of the application, and must describe the need for additional funding and categorical costs.

Please note that Chinese co-investigators will be required to submit the contents of the entire NIH application to NSFC (in addition to the NSFC application) for review. This application copy will also be confidentially reviewed during the Chinese review. It is expected that the Chinese collaborator will contact the U.S. PD/PI and request copies of their application for submission.

Applicants are strongly encouraged to submit requests electronically as an attachment in pdf format via email; however, the signature of the Authorized Organizational Representative (AOR) must be clearly visible. Administrative supplement requests may be submitted at any time, but must be received by no later than 5:00PM Eastern Time on April 14, 2011.  

As an alternative, requests can be submitted via CD to be mailed to the point of contact listed below (with the signature of the Authorized Organizational Representative [AOR] clearly visible in the application) and must be postmarked no later than April 7, 2011.

Late submissions will not be considered.

The contact information for submission is:

For NCI:
Bryan Baker
Office of Grants Administration
National Cancer Institute
6120 Executive Boulevard, EPS Suite T-44, MSC 7111
Bethesda, MD 20892-7111 (for U.S. Postal Service regular and express mail
Rockville, MD 20852 (for non-U.S. Postal Service delivery)
Telephone: (301) 496-9356
E-mail: bb117a@nih.gov

For NIAID:
Maggie C. Wells
Grants Management Specialist
National Institute of Allergy and Infectious Diseases
6700B Rockledge Drive, Room 2250, MSC 7614
Bethesda, MD 20892-7614
Telephone: (301) 594-9847
Fax: (301) 493-0597   
E-mail: mw509s@nih.gov

For applications to Other NIH Institutes and Centers in the area of HIV/AIDS and its co-morbidities:

Robert W. Eisinger, Ph.D.
Director of Scientific and Program Operations
and Chair, Therapeutics Coordinating Committee
Office of AIDS Research
National Institutes of Health
5635 Fishers Lane, Room 4015, MSC 9310
Bethesda, Maryland 20892-9310
Telephone: (301)-496-0358
Fax: (301)402-8638
E-mail: be4y@nih.gov 

Application Procedure:

Requests should be submitted on the PHS398 Application Guide forms (font size and other formatting rules apply as designated in the instructions), as indicated below. Include only the following elements:

Cover Letter, which cites this Notice and contains the following information:

PHS 398 Form Page 1 (Face page)

PHS 398 Form Page 2

A brief application describing the project that is being proposed in collaboration with the Chinese co-investigator, containing:

Other required components of the application (submitted in addition to the research plan) are:

Selection

Administrative supplement requests will be evaluated administratively by NIH Staff. Selection factors will include the following:

Reviewers also will examine the appropriateness of the budgets in consideration of the study proposed and the research environment for the scientific projects.

Additional selection factors include:

Significance. Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?

Investigator(s). Are the PD/PIs, collaborators, and other researchers well suited to the project? If submitters are Early Stage Investigators or New Investigators, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? Do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

Innovation. Does the proposed research challenge and seek to shift current understanding or clinical practice paradigms by utilizing novel theoretical concepts, approaches, or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?

Approach. Are the overall strategies, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?
If the project involves research in human populations, are the plans for: 1) protection of human subjects from research risks; and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?

Environment. Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?

Inquiries

Inquiries and discussion of plans for responding to this Notice are strongly encouraged.

For NCI:
Geraldina Dominguez, Ph.D.
Office of HIV and AIDS Malignancy
National Cancer Institute
31 Center Drive, Room 3A33, MSC 2440
Bethesda, MD 20852-2440
Telephone: (301) 496-3204
Fax: (301) 480-4137
E-mail: domingug@mail.nih.gov

or

Julie A. Schneider, Ph.D.
Program Director, Office of China Cancer Programs
U.S. Embassy Beijing
No. 55 An Jia Lou Lu
Beijing 100600 P.R. China
Telephone: 8610-8531-3986
E-mail: schneidj@mail.nih.gov

For NIAID:
Gayle Bernabe, M.P.H.
Regional Program Officer
Office of Global Research (OGR)
National Institute of Allergy and Infectious Diseases
National Institutes of Health
6610 Rockledge Drive, Room 5211
Bethesda, MD 20892-6613 (20817 for express delivery)
Telephone: (301) 451-1018
Fax: (301) 480-2954
E-mail: gbernabe@niaid.nih.gov

or

Ray Chen, M.D., M.S.P.H.
Medical Officer
Office of Global Research
National Institute of Allergy and Infectious Diseases
National Institutes of Health
U.S. Embassy Beijing
No. 55 An Jia Lou Lu
Beijing 100600 P.R. China
E-mail: rchen@niaid.nih.gov

or

Lara R. Miller, M.S.
Program Officer
Basic Immunology Branch
National Institute of Allergy and Infectious Diseases
National Institutes of Health
6610 Rockledge Drive, Room 6307, MSC 6601
Bethesda, MD 20892-6601 (20817 for express delivery)
Telephone: (301) 496-7551
Fax: (301) 480-2381
E-mail: lrmiller@niaid.nih.gov

For applications to other NIH Institutes and Centers in the area of HIV/AIDS and its co-morbidities:

Robert W. Eisinger, Ph.D.
Director of Scientific and Program Operations
and Chair, Therapeutics Coordinating Committee
Office of AIDS Research
National Institutes of Health
5635 Fishers Lane, Room 4015, MSC 9310
Bethesda, Maryland 20892-9310
Telephone: (301)-496-0358
Fax: (301)402-8638
E-mail: be4y@nih.gov 


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