RELEASE DATE:  April 11, 2003

NOTICE:  NOT-CA-03-027

National Cancer Institute (NCI)

The Division of Cancer Prevention (DCP) of the National Cancer 
Institute (NCI) announces the availability of funds to support a 
program to supplement NCI-funded research project (R01), MERIT (R37), 
cooperative agreement (U01) program project (P01) grants, NCI Cancer 
Center (P30) or SPORE (P50) grants to assist with the collection of 
tissue samples, isolation of RNA and shipment to NCI for RNA expression 
analysis by a dedicated microarray facility operated by the Center for 
Cancer Research and the Division of Cancer Prevention.  This effort, 
known as the Bio-Active Nutrient Gene Expression Omnibus (BANGEO) 
project, will support collaborative activities between ongoing NCI-
supported studies examining the effects of bio-active nutrients 
associated with cancer prevention and the microarray facilities of the 
NCI Advanced Technology Center, as well as the gene expression analysis 
resources available under the auspices of the NCI Center for 
Bioinformatcs (NCICB).  At this time the species eligible for this 
effort are rat, mouse and human.

NCI-funded investigators whose research involves investigations of the 
effects of nutrients and who do not currently have funding to examine 
the effects of gene expression as part of their ongoing grant are 
eligible.  The original peer review-approved goals do not need to 
mention microarray analysis.  This project is designed to take 
advantage of new opportunities afforded by the establishment of the 
microarray center and the ongoing efforts in bioinformatics at the 
NCICB and the National Center for Biotechnology Information.  The bio-
active nutrient proposed for study must be within the scope of the 
research originally approved by peer review.  No funds will be 
available for additional animal or human subjects other than those 
already being treated.  Funds will be available through administrative 

A full description of the BANGEO project, guidelines, and instructions 
for submission can be found at the following web site:  It details 
the opportunities available to NCI grantees for the identification of 
nutrient-dependent changes in gene expression through collaborative 
activities with the Advanced Technology Center, which will be funded 
with administrative supplements to their active grants.  It also 
provides mechanisms for requesting these supplements as well as 
specific program requirements for eligibility.

Requests for BANGEO supplemental support will be accepted on May 15, 
2003, on November 15, 2003, March 15, 2004, on November 15, 2004, and 
on March 15, 2005.


Investigators funded by any division in NCI who are interested in the 
activities described here are highly encouraged to contact their NCI 
program director whose name and telephone number are cited in the 
latest Notice of Grant Award to solicit advice about the 
appropriateness of the request.

For further information, contact:

Harold E. Seifried, Ph.D.
National Cancer Institute
National Institutes of Health 
Department of Health and Human Services
Executive Plaza North, Room 3158
Bethesda, MD  20892-7381
Telephone:  (301) 594-7657
FAX:  (301) 480-3925

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