BROAD AGENCY ANOUNCEMENT N01-CO-27042-32 - FUNDAMENTAL TECHNOLOGIES FOR DEVELOPMENT OF BIOMOLECULAR SENSORS Release Date: July 1, 2002 NOTICE: NOT-CA-02-020 National Cancer Institute (NCI) (http://www.nci.nih.gov/) The NCI/NASA Fundamental Technologies for the Development of Bimolecular Sensors Program is soliciting projects to develop the fundamental elements of technology systems or system components that will measure, analyze, and manipulate molecular processes at appropriate scale in the living body. The discoveries from this program are intended to enable the development of complete systems for the in vivo sensing of signatures of pathologic cell types or closely associated micro environmental factors that provide a seamless interface between sensing/detection and delivery of signature-specific intervention. This is the second solicitation issued in support of this program. In FY2002, the NCI and NASA awarded 13 contracts to initiate the program. Under this solicitation, the NCI and NASA each anticipate awarding an additional 10-14 contracts, grants, or cooperative agreements. Specific areas for fundamental technology development targeted by this solicitation include: o novel molecular recognition chemistries, materials, chemical composites, nanoparticles, nanostructures, agents, and devices suitable for in vivo use, o novel strategies for in vivo signal generation and amplification, o non-invasive dynamic signal acquisition systems suitable for non-invasive, dynamic signal acquisition from deep tissues and systems of reduced scale suitable for manned space missions. o new tools for feature definition and extraction, including computational and mathematical approaches, and o new approaches and multifunctional technology platforms to create an interface between in vivo detection and targeted intervention, including nanostructures/devices and novel materials and composites. The detailed Broad Agency Announcement (N01-CO-27042-32) is available on the web site of the Research Contracts Branch, National Cancer Institute at: http://rcb.cancer.gov/rcb-internet/appl/rfp/27042/toc.pdf INQUIRIES: Mr. Richard L. Hartmann Contracting Officer National Cancer Institute Research Contracts Branch, TBSS 6120 Executive Boulevard MSC 7193 Bethesda, MD 20892-7193 Telephone: 301-496-8620 Fax: 301-402-6699 Email inquiries to: hartmari@mail.nih.gov
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