Release Date:  May 21, 2002

NOTICE:   NOT-CA-02-017

National Cancer Institute 

The Cancer Centers Branch of the Office of Centers, Training, and Resources 
at the National Cancer Institute (NCI) invites grant applications from NCI-
designated Clinical and Comprehensive Cancer Centers for participation in a 
pilot program focused on identifying and overcoming barriers to early phase 
cancer clinical trials.  The purpose of this initiative is to enhance 
national capability to test innovative agents by developing a spectrum of 
exportable models that NCI Cancer Centers and other organizations can use for 
increasing and sustaining   accrual rates of patients to such trials.  NCI 
Cancer Centers are particularly suited for participation in this pilot 
program as they have the infrastructure available for conduct of early phase 
clinical trials, are located in a variety of geographic settings with access 
to diverse populations, have strong linkages to the communities they serve, 
and are recognized by industry and the NCI as the best organizations for 
testing new therapeutic agents. Applicants that are selected for funding must 
agree to share all information and models that are developed through this 
initiative with the broader cancer research community and with the NCI.

This is a collaborative initiative of the NCI and the Foundation of the 
National Institutes of Health, Inc., which is in partnership with the 
following pharmaceutical firms: Aventis, Bristol-Myers Squibb, 
GlaxoSmithKline, Eli Lilly, and Novartis.  Support will be through the 
National Institutes of Health exploratory/developmental grant (R21) award 
mechanism.   Approximately $3.0 million in total costs will be made available 
for each of two years.  Half of this amount is to provided by the NCI and 
half provided through the industrial partners as represented by the 
Foundation for the National Institutes of Health, Inc.  The maximum total 
cost requested in each cancer center application for support cannot exceed 
$600,000 per year.  The NCI expects to make 5 to 8 awards.

NCI staff will contact the current grantees directly regarding other special 
requirements, application procedures, and format.


Inquiries are encouraged and the opportunity to clarify issues and answer 
questions is welcome.  Inquiries may be directed to:

Linda K. Weiss, Ph.D., Chief
Cancer Centers Branch
Office of Centers, Training, and Resources
National Cancer Institute
6116 Executive Boulevard
Suite 700
Bethesda, Maryland 20892-8345
Phone: 301 496-8531
Fax: 301 402-0181

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