Release Date:  December 20, 2000

NOTICE:  CA-01-005

National Cancer Institute

The NCI/NASA Fundamental Technologies for the Development of Biomolecular 
Sensors Program is soliciting projects to develop the fundamental elements of 
technology systems or system components that will measure, analyze, and 
manipulate molecular processes at appropriate scale in the living body. The 
discoveries from this program are intended to enable the development of complete 
systems for the in vivo sensing of signatures of pathologic cell types or 
closely associated microenvironmental factors that provide a seamless interface 
between sensing/detection and delivery of signature-specific intervention.  Both 
contracts and grants may be funded from this solicitation.

Specific areas for fundamental technology development targeted by this 
solicitation include: 

1.  novel molecular recognition chemistries, materials, chemical composites, 
nanoparticles, nanostructures, agents, and devices suitable for in vivo use.
2.  novel strategies for in vivo signal generation and amplification.
3.  non-invasive dynamic signal acquisition systems suitable for non-invasive, 
dynamic signal acquisition from deep tissues and systems of reduced scale 
suitable for manned space missions.
4.  new tools for feature definition and extraction, including computational and 
mathematical approaches.
5.  new approaches and multifunctional technology platforms to create an 
interface between in vivo detection and targeted intervention, including 
nanostructures/devices and novel materials and composites.

The detailed Broad Agency Announcement (BAA AVAILABLE: N01-CO-17016-32) is 
available on the web site of the Research Contracts Branch, National Cancer 
Institute at:


Mr. Richard L. Hartmann
Contracting Officer
National Cancer Institute
Research Contracts Branch, TBSS
6120 Executive Boulevard MSC 7220
Bethesda, MD 20892-7220
Telephone:  301-496-8620
Fax:  301-402-6699
Email inquiries to:

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