Key Dates
- August 09,2024 - HEAL Initiative: NIH-DOD-VA Pain Management Collaboratory Pragmatic and/or Implementation Science Demonstration Projects ((UG3/UH3) Clinical Trial Required). See NOFO RFA-AT-24-011.
National Center for Complementary and Integrative Health (NCCIH)
The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit UG3/UH3 phased cooperative agreement research applications to conduct efficient, large-scale pragmatic clinical trials and/or implementation science demonstration projects within the infrastructure of the NIH-DOD-VA Pain Management Collaboratory (PMC) on nonopioid approaches to the management of pain and other comorbid conditions, including complementary and integrative approaches used alone and in combination with standard care (e.g., mindfulness meditation combined with standard pharmaceutical treatment), and improving prevention and treatment for opioid misuse and addiction in U.S. Veterans, military personnel, and their families. Supporting the trials, the PMC has established a coordinating center that provides national leadership and technical expertise for all aspects of health care system (HCS)-focused research including assistance to UG3/UH3 grant recipients.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The NOFO is expected to be published in Fall 2024 with an expected application due date in November 2024.
This NOFO will utilize the UG3/UH3 activity code. Details of the planned NOFO are provided below.
This Notice encourages investigators with expertise and insights into this area of nonopioid pain management interventions, implementation science, and pragmatic clinical trials research to begin to consider applying for this new NOFO.
In addition, collaborative investigations combining expertise in conducting clinical trials in U.S. Veteran and military health care systems will be encouraged and these investigators should also begin considering applying for this application.
Among the areas of research encouraged in this initiative are:
- Design and execution of high-impact Demonstration Projects that will conduct pragmatic clinical trials focusing on effectiveness research, implementation research, or hybrid effectiveness-implementation research on nonopioid approaches for the management of pain and comorbidities with patients in health care delivery systems that provide care to Veterans, military personnel, and their families.
- Applications are expected to make available data, tools, best practices, and resources from these Demonstration Projects to facilitate a research partnership with health care delivery systems that provide care to Veterans, military personnel, and/or their families.
- Effectiveness trials of approaches that have not yet been evaluated for effectiveness in the VA and/or DOD health care settings. Applicants are strongly encouraged to review the PMC website to avoid submitting a trial that overlaps significantly with other ongoing or completed PMC trials.
Funding Information
The NIH HEAL Initiative intends to commit an estimated total of $850,000 to fund one award in FY 2025.
Up to 1 award pending availability of funds and receipt of meritorious applications.
The application budget for the UG3 phase is limited to $500,000/year in direct costs. Costs for each year of the UH3 phase are limited to $1,000,000/year in direct costs. The UG3 phase is limited to 1 year, and the UH3 phase can request up to 4 years of support. The total project period for an application submitted in response to this NOFO may not exceed 5 years.
92.213
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government
Applications are not being solicited at this time.
Inquiries
Please direct all inquiries to:
Pete Murray, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Phone: 301-496-4054
Email: peter.murray@nih.gov
and Human Services (HHS)
