NIH AUTOIMMUNE RAT MODEL REPOSITORY AND DEVELOPMENT CENTER Release Date: March 26, 2001 NOTICE: NOT-AR-01-005 National Institute of Arthritis and Musculoskeletal and Skin Diseases The NIH Animal Genetic Resource of the Veterinary Resources Program/ Office of Research Services and the National Institute of Arthritis and Musculoskeletal and Skin Diseases The NIH Autoimmune Rat Model Repository and Development Center announces the availability of breeding stock of standard and new rat strains for research on autoimmune disorders. Information concerning rat strains currently available and nearing release is available from the resource managers listed below and will be listed on the resource web site at: http://www.ors.od.nih.gov/dirs/vrp/ratcenter/. The NIH Autoimmune Rat Model Repository and Development Center was established in 2000 and is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The purpose of the Repository is to facilitate the availability of genetically- standardized rat strains for experimental research of the role of autoimmunity in diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, encephalomyelitis, spondyloarthropathy, and other diseases. The NIH Animal Genetic Resource of the Veterinary Resources Program, Office of Research Services, NIH operates the Autoimmune Rat Model Repository and Development Center. Resource Objectives 1. To acquire, characterize, establish, develop, and cryopreserve foundation colonies of genetically-characterized autoimmune rat models. All strains will be re-derived on arrival to eliminate disease pathogens and parasites that may complicate research. Breeding stock will be available to qualified biomedical investigators worldwide. 2. To assist autoimmune research investigators in the development of novel and enhanced models using special breeding schemes to obtain inbred (e.g., standard inbred strains, congenic, recombinant inbred, consomic, recombinant congenic) and outbred models. Projects will be selected using criteria established with the assistance of an Advisory Group consisting of NIH intramural, extramural and international investigators. Inquiries regarding the availability of rat models of autoimmune disorders should be addressed to: Drs. Carl T. Hansen and Dr. William F. Rall, Resource Managers Veterinary Resources Program/Office of Research Services/NIH 14 Service Road South, Building 14F, Room 101 Bethesda, MD 20892-5590 Telephone: (301) 496-5525 Fax: (301) 402-4258 E-mail: ch45j@nih.gov or br18a@nih.gov
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