RFP ANNOUNCEMENT: Nonhuman Primate Core Quantitative Viral RNA Laboratory for AIDS Vaccine Research and Development: RFP-NIAID-DAIDS-NIH-AI-2009-073

Notice Number: NOT-AI-10-021

Key Dates
Release Date:  April 5, 2010
RECEIPT DATE: July 2, 2010 

Issued by
National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov)


This requirement is a re-competition of contract number N01-AI-30057; Advanced BioScience Laboratories, Inc.

The NIAID provides immunological and virological support for nonhuman primate studies conducted at NIAID’s Simian Vaccine Evaluation Unit contract sites (SVEUs) and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development, previously called the NHP “Core Laboratories.”  The objective of the Core Laboratories has been to insure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines. 

The purpose of the proposed contract is to provide a nonhuman primate virology laboratory that will conduct quantitative viral RNA measurements in support of studies that evaluate prototype AIDS vaccines in nonhuman primates. The contract will support the conduct, improvement, and development of assays designed to measure viral RNA loads in nonhuman primates that have been immunized with candidate HIV or SIV vaccines and challenged with SIV or SHIV in studies conducted at DAIDS Simian Vaccine Evaluation Unit contract sites or by NIH-supported investigators.

The Contractor shall use state-of the-art technologies to accomplish the contract objectives and shall incorporate new and improved technologies into contract activities when appropriate.  The Contractor shall focus on the development, optimization, and conduct of assays to detect and assess antiviral neutralizing antibodies from immunized and infected animals. The Contractor shall use GLP processes to conduct assays when assessing humoral immune responses in NHP studies conducted with human clinical candidate AIDS vaccines.

It is anticipated that one cost reimbursement, term type contract will be awarded for a 1-year Base period plus six 1-year options for a possible total period of performance of 7 years beginning on or about March 30, 2011. The performance requirement will be for the delivery of 2.04 full time equivalents (FTEs) per year for the base period (Year 1) and option periods (Years 2 through 7), which may be unilaterally exercised by the Government.  In addition, the Government may exercise options to accommodate significant increases in work to be provided for the base period and option periods.  Should the Government elect to exercise these options, the Contractor shall provide resources for the unanticipated increase in work volume for .35 additional FTEs for each option exercised.  The Government may exercise an option up to three times in any year of the contract. 

The NAICS Code is 541712 with a size standard of 500 employees. 

The anticipated period of performance is March 30, 2011 through March 29, 2012 with 1 year options to extend the period for six additional years through March 29, 2018.

Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on/about April 2, 2010, and may be accessed through the NIAID Office of Acqusitions (OA) Home Page at http://www.niaid.nih.gov/contract and through FedBizOpps http://www.fedbizopps.gov/.  This notice does not commit the Government to award a contract.  No collect calls will be accepted.  No facsimile transmissions will be accepted.


Direct inquiries and technical issues to:

Anita Hughes
Team Leader
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive Room 3221, MSC 7612 (Express mail:  Use Zip Code 20817-7612)
Phone: 301-451-3694
Fax: 301-480-4675

Eileen Webster-Cissel
Contracting Officer
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive Room 3149, MSC 7612 (Express mail:  Use Zip Code 20817-7612)
Phone: 301-496-0612
Fax: 301-480-4675
Contracting Office Address

Department of Health and Human Services
National Institutes of Health
National Institute of Allergy and Infectious Diseases
Division of Extramural Activities
Office of Acquisitions
6700-B Rockledge Drive
Room 3214, MSC 7612
Bethesda, MD 20892-7612


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