RFP ANNOUNCEMENT: Nonhuman Primate Core Cellular Immunology Laboratory for AIDS Vaccine Research and Development RFP-NIAID-DAIDS-NIH-AI-2009-071

Notice Number: NOT-AI-09-055

Key Dates
Release Date:  September 16 2009                                   
Receipt Date: December 2, 2009 

Issued by
National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov)


This requirement is a re-competition of contract number N01-AI-30033; Beth Israel Deaconess Medical Center, Inc.

The National Institute of Allergy and Infectious Diseases (NIAID) provides immunological and virological support for nonhuman primate (NHP) studies conducted at NIAID’s Simian Vaccine Evaluation Unit contract sites (SVEUs) and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development, previously called the NHP “Core Laboratories.”  The objective of the NHP Core Laboratories is to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines. 

The purpose of the proposed contract will be to support the conduct, improvement, and development of assays designed to evaluate and characterize the cellular immune responses of NHPs that have been immunized with candidate HIV or SIV vaccines or infected with SIV, SHIV, or HIV in studies conducted at the NIAID SVEU contract sites or by NIH-supported investigators.

The contractor shall use state-of-the-art technologies, including ELISPOT, intracellular cytokine staining (ICS), flow cytometry, and tetramer assays to accomplish the contract objectives, and shall incorporate new and improved technologies into contract activities when appropriate.  The contractor will be expected to pursue the development of assays to detect immune responses in mucosal tissues, including assays that are able to detect virus-specific responses using small numbers of cells.  The contractor will use GLP processes to conduct assays when assessing cellular immune responses in NHP studies conducted with human clinical candidate AIDS vaccines, to allow the assay results to be compared with assays being conducted with the same vaccines in human clinical trials.

It is anticipated that one cost reimbursement, term type contract will be awarded for a 1-year Base period plus six 1-year options for a possible total period of performance of 7 years beginning on or about   August 12, 2010. The performance requirement will be for the delivery of 7.6 full time equivalents (FTEs) per year for the base period (Year 1) and option periods (Years 2 through 7), which may be unilaterally exercised by the Government.  In addition, the Government may exercise options for increased level of effort that may result from unanticipated increase in demand for the conduct of cellular immunology assays.  Should the Government elect to exercise this option, the Contractor shall provide resources for the unanticipated increase in work volume for up to .95 FTE’s for each option exercised.  The Government may exercise these options up to two times within each performance year. 

The NAICS Code is 541712 with a size standard of 500 employees. 

The Period of Performance is unknown at this time.

Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on/about September 4, 2009, and may be accessed through FedBizOpps http://www.fedbizopps.gov/ and the NIAID Office of Acquisition (OA) Home Page at http://www.niaid.nih.gov/contract.  This notice does not commit the Government to award a contract.  No collect calls will be accepted.  No facsimile transmissions will be accepted.


Direct inquiries and technical issues to:

Matthew Gormley,
Contract Specialist
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive Room 3221, MSC 7612 (Express mail:  Use Zip Code 20817-7612)
Phone: 301-451-3683
Fax: 301-480-4675

Michelle L. Scala,
Contracting Officer
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive Room 3106, MSC 7612 (Express mail:  Use Zip Code 20817-7612)
Phone: 301-451-3693
Fax: 301-480-4675


Department of Health and Human Services
National Institutes of Health
National Institute of Allergy and Infectious Diseases
Division of Extramural Activities
Office of Acquisitions
6700-B Rockledge Drive
Room 3214, MSC 7612
Bethesda, MD 20892-7612


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