Simian Vaccine Evaluation Units (SVEUs) RFP-NIH-NIAID-DAIDS-06-15

Notice Number: NOT-AI-05-039

Key Dates
Release Date: May 5, 2005
Proposal Receipt Date(s): August 8, 2005
Peer Review Date(s): December, 2005
Earliest Anticipated Start Date: May 8, 2006
Expiration Date: March 31, 2006

Issued by
National Institute of Allergy and Infectious Diseases (NIAID), (http://www.niaid.nih.gov/)

The National Institute of Allergy and Infectious Diseases (NIAID), NIH has a requirement to establish three to four Simian Vaccine Evaluation Units for evaluation of SIV and HIV vaccine approaches in support of preclinical AIDS vaccine research and development. For this project, the Division of AIDS, NIAID, is seeking organizations with the technical expertise and facilities needed to house 100 – 300 nonhuman primates in BSL2 and BSL2/3 containment facilities and to conduct preclinical evaluations of the immunogenicity and efficacy of simian immunodeficiency virus (SIV) and HIV candidate vaccines in the nonhuman primates. Studies are conducted at the initiation of the NIAID, and vaccines to be evaluated are selected by NIAID. The Contractor will provide the nonhuman primates and the scientific and technical expertise necessary to conduct preliminary studies on new vaccines, conduct larger-scale studies on vaccines that have already demonstrated promise, evaluate the immunogenicity and safety of candidate HIV vaccines in anticipation of Phase II human clinical trials, and conduct comparative studies on vaccines and/or adjuvants from multiple sources. The SVEUs may also conduct studies with passively administered vaccines. The SVEUs are expected to provide non-human primates for the studies, immunize animals with candidate vaccines, conduct initial assessments of immune responses, challenge the non-human primates with infectious virus, and determine whether or not the animals become infected. The SVEUs also conduct in vivo titrations of virus challenge stocks and may conduct microbicide studies to evaluate the ability of topically administered microbicides and other antiviral substances to block infection of non-human primates with virus administered vaginally or by other mucosal routes. The proposed contracts will continue the work of the current SVEUs. It is anticipated that three to four (3-4) completion type contracts will be awarded as a result of this solicitation. This project will take approximately seven years to complete. It is anticipated that three to four cost reimbursement, completion type contracts will be awarded, each with a period of seven (7) years, beginning approximately May 8, 2006. RFP NIH-NIAID-DAIDS-06-15 will be available electronically on or about May 6, 2005 with a closing date tentatively set for August 8, 2005, and may be accessed through the NIAID Contract Management Program (CMP) Home Page at http://www.niaid.nih.gov/contract -- and will also be posted on FedBizOps. Any responsible Offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. No collect call will be accepted.

Inquiries

For questions or further information, contact:

Michelle Scala
Contracting Officer
Division of AIDS
National Institute of Allergy and Infectious Diseases
Room 4142, MSC-7620
6700-B Rockledge Drive
Bethesda, MD 20892-7620
Bethesda, MD 20817 (for express/courier service; non-USPS service)
Telephone: 301-451-3693
FAX: 301-402-0972
Email: mscala@niaid.nih.gov


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