NIAID RESEARCH PROGRAMS FOR TOPICAL MICROBICIDES

RELEASE DATE:  March 22, 2004

NOTICE: NOT-AI-04-021

National Institute of Allergy and Infectious Diseases (NIAID) 
 (http://www.niaid.nih.gov)
National Institute of Child Health and Human Development (NICHD) 
 (http://www.nichd.nih.gov/)

DESCRIPTION

This Notice is to highlight microbicide research opportunities sponsored by 
NIH. The grant and contract programs shown here integrate to provide a 
complete research path from earliest discovery through proof of concept 
testing.  The NIH is seeking applications at each stage of development to 
bolster the breadth and depth of the science we are supporting. A brief 
description of each program follows.

INNOVATION GRANTS FOR AIDS RESEARCH - PA 02-046 
(http://grants.nih.gov/grants/guide/pa-files/PA-02-046.html) 

This PA seeks applications at the earliest steps in the microbicide 
development pathway. This solicitation seeks the submission of applications 
to bring new, scientifically challenging and untested ideas into AIDS 
research—including microbicides.  In brief, the sponsoring NIH institutes are 
seeking applications in the following areas for this PA:

Microbicide discovery - objectives may include, but are not limited to, new 
approaches for microbicides addressing: 

o viral and cellular processes involved in the transmission, local 
propagation, and spread of HIV
o processes for cervicovaginal and rectal transmission of HIV 
o improved methods of formulation and delivery 
o preclinical systems to test microbicide safety and efficacy

INTEGRATED PRECLINICAL/CLINICAL PROGRAM FOR TOPICAL MICROBICIDES—PAR-03-137 
(http://grants.nih.gov/grants/guide/pa-files/PAR-03-137.html) 

This solicitation provides opportunities to advance safe, novel topical 
microbicides and microbicide combination strategies that prevent the sexual 
transmission of HIV, from preclinical to clinical studies.  This purpose of 
this program is: (1) to encourage discovery and preclinical development of 
lead topical microbicide candidates and combinations, and (2) to foster 
translation of safe, new microbicides/ combinations from preclinical studies 
to pilot clinical studies.  The ultimate goal of this research is the 
development and exploratory clinical evaluation of new and potentially 
effective microbicides for the prevention of HIV sexual transmission.

HIV MICROBICIDE DESIGN AND DEVELOPMENT TEAMS – RFP-NIH-NIAID-DAIDS-04-04 
http://www.niaid.nih.gov/contract/rfps.htm

The HIV Microbicide Design and Development Teams (HMDDT) solicitation seeks 
to fund consortia of scientists with product development experience from 
industry and/or academia that have 1) identified a promising microbicide 
concept, and 2) devised a plan for its targeted development in to a product 
testable in humans.  The expectation is that the Teams advance their 
microbicide concepts along a well-defined development path in a timely manner 
to a microbicide product and in to clinical testing with the five-year period 
of the award.

WHERE TO SEND INQUIRIES

We encourage inquiries concerning these announcements and welcome the 
opportunity to answer questions from potential applicants. Inquiries may fall 
into three areas: scientific/research, peer review, and financial or grants 
management issues:

o Direct your questions about NIAID scientific/research issues to:

Dr. Roberta Black
Division of AIDS
National Institute of Allergy and Infectious Diseases
Room 4110, MSC-7628
6700-B Rockledge Drive
Bethesda, MD 20892-7628
Telephone: (301) 496-8199
FAX:       (301) 496-8530
E-Mail:     rb31i@nih.gov

o Direct your questions about NICHD scientific/research issues to:

Dr. Patricia Reichelderfer
Center for Population Research
National Institute of Child Health and Human Development
Room 8B13G, MSC 7510
6100 Executive Boulevard 
Bethesda, MD 20892-7510
Telephone: 301-496-1661
FAX:       301-480-1972
E-mail:    pr20f@nih.gov

o Direct questions about financial or grants management matters to:

Jane Unsworth
Division of Extramural Activities
National Institute of Allergy and Infectious Diseases  
Room 2128, MSC-7614
6700-B Rockledge Drive  
Bethesda, MD  20892-7614 
Telephone: (301) 402-6824 
FAX:       (301) 480-3780 
Email:      ju3a@nih.gov

o Direct questions about contract management matters to:

Donald E. Collie
Contracts Management Specialist
Division of Extramural Activities
National Institute of Allergy and Infectious Diseases  
Room 2233, MSC-7612
6700-B Rockledge Drive  
Bethesda, MD  20892-7614 
Telephone: (301) 496-0992
FAX:       (301) 402-0972
Email:      dcollie@niaid.nih.gov


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