RELEASE DATE:  September 22, 2003


National Institute of Allergy and Infectious Diseases (NIAID) 

RECEIPT DATE:  January 8, 2004


NIAID is establishing a Broad Agency Announcement (BAA) to solicit proposals 
to address the Institute's need for research programs focused on identifying 
associations between specific immune response gene polymorphisms and 
susceptibility to infection, or the quality of response to vaccination, with 
a focus on one or more of the high priority NIAID Category A, B, or C 
pathogens listed at  
The correlation of genetic polymorphisms with response to phenotypes, such as 
severity of infection, or with vaccination outcome, will be further studied 
through the analysis of expression levels and/or functions of the proteins 
encoded by the variant immune response genes.

The Offeror will obtain materials for such studies from patients with a 
history of natural infections; individuals currently enrolled in vaccine 
trials; and/or previously vaccinated high-risk groups, such as military, 
laboratory, and health care personnel.  In addition efforts will be made to 
include at-risk groups such as the very young, the elderly, and individuals 
with immunodeficiencies.  Genomic information from mouse model systems can be 
used to facilitate identification of relevant human immune response genes.  
Particular emphasis is placed on studies identifying host immune factors that 
play a role in controlling, protecting, or predisposing to an infection; 
exacerbating disease; determining resistance to treatments;.  
Interdisciplinary teams that combine diverse scientific expertise (e.g., 
microbiology, immunology, genetics, mathematics, computer science) will be 

The NIAID expects to award six (6) to twelve (12) cost reimbursement, 
completion type contracts, each with a period of five (5 year), beginning 
approximately September, 2004.  RFP-NIH-NIAID-DAIT-BAA-04-18 will be made 
available electronically on or about September 22, 2003 with proposals due on 
January 8, 2004, and may be accessed through the NIAID Contract Management 
Branch (CMB) Home Page at and will be 
posted on FedBizOpps at Any responsible offeror 
may submit a proposal that will be considered by the Government.  This 
announcement does not commit the Government to make an award.  No collect 
calls will be accepted.  No facsimile transmission will be accepted.

Contracting Office Address:

Department of Health and Human Services
National Institutes of Health
National Institutes of Allergy and Infectious Diseases
Contract Management Branch 
6700-B Rockledge Drive
Room 2230, MSC 7612 
Bethesda, MD, 20892-7612

Original Point of Contact:

Nancy Hershey, Contract Specialist, Phone 301-496-0193, Fax 301-402-0972, 
Email Jacqueline Holden, Senior Contracting Officer, 
Phone 301-496-7119, Fax 301-402-0972, Email

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