Release Date:  November 29, 2000

NOTICE:  AI-01-002

National Institute of Allergy and Infectious Diseases
National Cancer Institute

Letter of Intent:          January 2, 2001
Application Receipt Date:  January 15, 2001

The National Institute of Allergy and Infectious Diseases (NIAID) 
and National Cancer Institute (NCI) invite the submission of 
proposals to their new drug development program initiative.  This 
pilot program is designed to help AIDS research investigators 
facilitate the preclinical development of: 1) therapies for the 
treatment of HIV disease, AIDS-associated malignancies, 
opportunistic infections and tuberculosis associated with AIDS, and 
2) microbicide-based prevention strategies for HIV.  The program 
does not fund grants.  Instead, applications to the program are 
requests to NIAID and NCI to use their drug development resources to 
conduct specific tasks the applicants themselves are unable to carry 
out in their efforts to translate basic research findings to applied 
or clinical practice.  Examples of tasks that may be requested 
include High Throughput Screen (HTS) assay development, evaluation 
in animal efficacy models, Good Manufacturing Practice (GMP) scale-
up synthesis of small molecules and biologics, clinical dosage 
formulation and manufacturing, and Good Laboratory Practice (GLP) 
toxicology.  Program proposals will be solicited twice a year and 
reviewed in a competitive manner.  

The current deadline for receipt of applications is January 15, 
2001; prior to that date (no later than January 2) a Letter of 
Interest must be submitted to the Inter-Institute Program 
Coordinator.  Further information about this program, including 
detailed instructions for preparing proposals and the Letter of 
Interest, can be found at the pilot program web site at

James Drake, Developmental 
Inter-Institute Program Coordinator
Therapeutics Program, NCI, Executive Plaza North Suite 8000, 6130 
Executive Boulevard
Rockville, MD 20852, 
T 301.496.8720; F 301.402.0831.

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