Notice of Correction to the Resource Sharing Plan Instructions in the Overall Component in RFA-AG-15-001 "Alzheimer's Disease Core Centers (P30)"

Notice Number: NOT-AG-14-006

Key Dates
Release Date: February 5, 2014

Related Announcements
RFA-AG-15-001

Issued by
National Institute on Aging (NIA)

Purpose

The purpose of this Notice is to clarify the instructions for the Resource Sharing Plan of the Overall Component for RFA-AG-15-001 "Alzheimer's Disease Core Centers (P30)"

The Funding Opportunity Announcement (FOA) is modified as follows:

Section IV. Application and Submission Information
2. Content and Form of Application Submission
PHS 398 Research Plan (Overall)

Current Language:
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the SF424 (R&R) Application Guide, with the following modification:

Consistent with achieving the goals of this program, applicants should commit to cooperate fully and to share specimens with other research scientists both within and outside the Centers network as well as data concerning clinical core participants with the NIA-sponsored National Alzheimer’s Coordinating Center (NACC) where uniform data from all AD Centers is centrally stored. Any genetic specimens collected by the Center (blood samples and DNA) should be made available to the National Cell Repository for Alzheimer’s Disease (NCRAD) in accordance with agreed upon protocols and policies.  Centers may also be requested to contribute other biological samples such as serum and cerebrospinal fluid, using agreed upon protocols, for trans-center studies examining biomarkers that might relate to risk, diagnosis or progression of AD. Therefore, consent forms should be written to allow for this possibility as well as for the possibility of eventual data sharing with the wider research community, while maintaining participants’ confidentiality. The Steering Committee of the NACC in conjunction with the ADC Directors and the NIA sets policies that allow the individual Centers to conduct research on patients and control subjects collected by the individual Center while also sharing common data sets with NACC.

Applicants should follow NIA and NIH policies on data and sample sharing (please see the following web pages for further information, including example language that may be used in consent forms:
http://grants.nih.gov/grants/policy/data_sharing/
http://www.nia.nih.gov/research/dn/alzheimers-disease-genetics-sharing-plan
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html

Revised Language:
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans [Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)] as provided in the SF424 (R&R) Application Guide, with the following modification:

Consistent with achieving the goals of the program, applicants should commit to cooperate fully and to share specimens with other research scientists both within and outside the Centers network as well as data concerning clinical core participants with the NIA-sponsored National Alzheimer’s Coordinating Center (NACC) where uniform data from all AD Centers is centrally stored. Blood samples and/or DNA from all subjects enrolled in the clinical core should be sent to the National Cell Repository for Alzheimer’s Disease (NCRAD) in accordance with agreed upon protocols and policies, and procedures should be outlined in the application. Centers may also be requested to contribute other biological samples such as serum and cerebrospinal fluid, using agreed upon protocols, for trans-center studies examining biomarkers that might relate to risk, diagnosis or progression of AD. Therefore, consent forms should be written to allow for specimen sharing as well as for the possibility of eventual data sharing with the wider research community, while maintaining participants’ confidentiality. The Steering Committee of the NACC in conjunction with the ADC Directors and the NIA sets policies that allow the individual Centers to conduct research on patients and control subjects collected by the individual Center while also sharing common data sets with NACC.

Applicants should follow NIA and NIH policies on data and sample sharing. Please see the following web pages for further information, including example language that may be used in consent forms:
http://grants.nih.gov/grants/policy/data_sharing/
http://www.nia.nih.gov/research/dn/alzheimers-disease-genetics-sharing-plan
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html

All other aspects of the FOA remain the same.

Inquiries

Please direct all inquiries to:

Nina Silverberg, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-9350
Email: silverbergn@mail.nih.gov

 

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